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HOAt

HOAt Structure
HOAt structure
CAS No.
39968-33-7
Chemical Name:
HOAt
Synonyms
1-Hydroxy-7-azabenzotriazole;HO-EPCP;[1,2,3]Triazolo[4,5-b]pyridin-3-ol;3-hydroxytriazolo[4,5-b]pyridine;1-Hydroxy-7-azabenzo;1-Hydroxy-7-azabenotriazole;N-Hydroxy-7-azobenzotriazole;1-Hydroxy-7-azabenzotriazole (HOAt);3H-[1,2,3]triazolo[4,5-b]pyridin-3-ol(SALTDATA: FREE);HOAT
CBNumber:
CB3256884
Molecular Formula:
C5H4N4O
Molecular Weight:
136.11
MDL Number:
MFCD00210053
MOL File:
39968-33-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:07:12
Product description Number Pack Size Price
HOAT ≥98% CS-W019594 5g $22
HOAT ≥98% CS-W019594 10g $32
HOAT ≥98% CS-W019594 25g $36
HOAT ≥98% CS-W019594 100g $112
HOAT ≥98% CS-W019594 500g $392
More product size
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HOAt Properties

Melting point 213-216°C
Boiling point 250.36°C (rough estimate)
Density 0.973 g/mL at 20 °C
refractive index n20/D 1.441
Flash point 213-216°C
storage temp. Store at RT.
solubility >6.8mg/mL in DMSO
form Powder
pka 5.85±0.58(Predicted)
color White to yellow
Decomposition 213-216 ºC
Major Application peptide synthesis
InChI InChI=1S/C5H4N4O/c10-9-5-4(7-8-9)2-1-3-6-5/h1-3,10H
InChIKey FPIRBHDGWMWJEP-UHFFFAOYSA-N
SMILES C12N(O)N=NC1=CC=CN=2
CAS DataBase Reference 39968-33-7(CAS DataBase Reference)
FDA UNII TX8XYH09H0
EPA Substance Registry System 3H-1,2,3-Triazolo[4,5-b]pyridine, 3-hydroxy- (39968-33-7)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exploding Bomb (GHS01)Exclamation Mark (GHS07)
GHS01,GHS07
Signal word  Warning
Hazard statements  H302-H204-H319-H315
Precautionary statements  P264-P270-P301+P312-P330-P501-P210-P240-P250-P280-P370+P380-P372-P373-P374-P401-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  T,Xi,F,Xn,E
Risk Statements  61-20/21-36-5-36/37/38-11-41-37/38-22-2-36/37
Safety Statements  53-45-37/39-26-16-39-35-36-36/37-28-15
RIDADR  UN 1993 3/PG 3
WGK Germany  1
HazardClass  IRRITANT
PackingGroup  Ⅱ
HS Code  29332990
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Eye Irrit. 2
Flam. Liq. 3
Repr. 1B

HOAt price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-W019594 HOAT ≥98% 39968-33-7 5g $22 2026-06-04 Buy
ChemScene CS-W019594 HOAT ≥98% 39968-33-7 10g $32 2026-06-04 Buy
ChemScene CS-W019594 HOAT ≥98% 39968-33-7 25g $36 2026-06-04 Buy
ChemScene CS-W019594 HOAT ≥98% 39968-33-7 100g $112 2026-06-04 Buy
ChemScene CS-W019594 HOAT ≥98% 39968-33-7 500g $392 2026-06-04 Buy
Product number Packaging Price Buy
CS-W019594 5g $22 Buy
CS-W019594 10g $32 Buy
CS-W019594 25g $36 Buy
CS-W019594 100g $112 Buy
CS-W019594 500g $392 Buy

HOAt Chemical Properties,Uses,Production

Description

HOAt (also known as 1-Hydroxy-7-azabenzotriazole) is a benzotriazole compound commonly used as a coupling reagent for amino acids and peptides. HOAt is also used as a solid-phase synthesis reagent for chiral peptide nucleic acids.

Chemical Properties

Clear, colorless liquid

Uses

1-Hydroxy-7-azabenzotriazole can be used as antibacterial, anti-aging and flame-retardant dendritic polyacrylate emulsion.

Application

HOAt is a triazole derivative used in amide coupling chemistry as an additive in combination with coupling agents. The most used coupling reagents with HOAt are the carbodiimides EDCI, DCC and DIC. HOAt is comparable to HOBt but gives a better performance. It has faster reaction rates, reduced racemisation, higher yields and visual indication of the reaction endpoint by colour change of the reaction mixture from yellow to colourless. The increased efficiency of HOAt compared to HOBt is related to the stabilisation of the activated intermediate via anchimeric effect, due to the formation of a hydrogen bond with the N atom in position 7 of the benzotriazole. As is HOBt, HOAt is explosive and is therefore required to be handled carefully.

General Description

HOAt is a commonly used peptide bond forming agent that may become an impurity in drug synthesis, but is not mutagenic. HOAt can be used for peptide fragment polycondensation and can also inhibit the racemization of peptide polycondensation.

reaction suitability

reaction type: Addition Reactions

Precautions

3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridine is stable, not hygroscopic, and can be stored indefinitely. HOAt (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridine) solutions in DMF (0.3 M) can be stored in an inert atmosphere for weeks. Syntheses of peptides carried out with freshly prepared and 4-week-old solutions show similar quality to the crude product. Violent decomposition may occur when dried at elevated temperatures.

HOAt Preparation Products And Raw materials

Raw materials

Preparation Products

2-Ethylpiperazine

HOAt Suppliers

Global( 504)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co.,Ltd.
+86-0512-68071238 +86-13771819922 june@highfine.com China 489 58
Xinxiang Juyuan Biological Technology Co., Ltd.
+8615637360870 sales@xxkfqchem.com China 19 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2950 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6366 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Supplier Advantage
Suzhou Highfine Biotech Co.,Ltd.
58
Xinxiang Juyuan Biological Technology Co., Ltd.
58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Finer Chemical Co., Ltd 		58
Xiamen AmoyChem Co., Ltd 		58
Standardpharm Co. Ltd. 		58

View Lastest Price from HOAt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
HOAt pictures 2026-06-04 HOAt
39968-33-7
 0.99 RongNa Biotechnology Co.,Ltd
1-Hydroxy-7-azabenzotriazole/HOAT pictures 2026-06-03 1-Hydroxy-7-azabenzotriazole/HOAT
39968-33-7
 1kg 99%min 100kg WUHAN FORTUNA CHEMICAL CO., LTD
HOAT pictures 2026-06-02 HOAT
39968-33-7
 $5200.00 1kg 99 50tons Xinxiang Juyuan Biological Technology Co., Ltd.
  • HOAt pictures
  • HOAt
    39968-33-7
  • 0.99
  • RongNa Biotechnology Co.,Ltd
  • HOAT pictures
  • HOAT
    39968-33-7
  • $5200.00
  • 99
  • Xinxiang Juyuan Biological Technology Co., Ltd.

HOAt Spectrum

HOAt(39968-33-7)MSHOAt(39968-33-7)1HNMRHOAt(39968-33-7)13CNMRHOAt(39968-33-7)IR1HOAt(39968-33-7)IR2

39968-33-7(HOAt)Related Search:

1,2,3-1H-Triazole 1-Hydroxybenzotriazole 5-Methyl-1H-benzotriazole 1H-Benzotriazole 1,2,4-Triazole
HATU N-Hydroxyphthalimide N-CHLOROSACCHARIN O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
HBTU 1-Hydroxybenzotriazole hydrate CHLOROPHOSPHONAZO III 2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate TBTU
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride HOAt (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate

1of4

N-Hydroxy-7-azobenzotriazole 3H-1,2,3-TRIAZOLO[4,5-B]PYRIDINE, 3-HYDROXY- 3H-[1,2,3]-TRIAZOLO[4,5-B]PYRIDIN-3-OL 7-AZA-1-HYDROXYBENZOTRIAZOLE 7-Aza-1-hydroxybenzotriazole HOAt 1-Hydroxy-7-azabenzotriazole N-Hydroxy-7-azabenzotriazole 3H-[1,2,3]Triazolo[4,5-b]pyridin-3-ol, 95+% HOAT 1-HYDROXY-7-AZABENZOTRIAZOLE 0.5 TO & 1-HYDROXY-7-AZABENZOTRIAZOLE SOLUTION, 0.5M IN DMF HOAT [1-HYDROXY-7-AZABENZOTRIAZOLE] 1-Hydroxy-7-Azabenzotriazole99%Puriss 1H-[1,2,3]triazolo[4,5-b]pyridine 3-Oxide 1-Hydroxy-7-azabenzotriazole solution 1-Hydroxy-7-azabenzotriazole (HOAt) 1-HYDROXY-7-AZABENZOTRIAZOL 3H-[1,2,3]-Triazolo[4,5-b]pyridin-3-ol, HOAt 1-Hydroxy-7-azabenzotriazole ,98% 3H-1,2,3-Triazolo[4,5-b]pyridin-3-ol [Peptide Coupling Additive] 1-Hydroxy-7-azabenzotriazole solution, 0.6 M in DMF [1,2,3]Triazolo[4,5-β]pyridin-3-ol 1H-[1,2,3]triazolo[4,5-β]pyridine 3-Oxide hoat（1－hydroxyl－7－azabenzotriazole） 1;2;3]TRIAZOLO[4;5-B]PYRIDIN-3-OL;1H-[1;2;3]TRIAZOLO[4;5-B]PYRIDINE 3-OXIDE;HOAT. 3]Triazolo[4 5-b]pyridin-3-ol 5-b]pyridine 3-Oxide Olaparib Impurity 18 (HOAT) Olaparib Impurity 23（HOAt） Olaparib Impurity 47 HOAT 1-Hydroxy-7-azabenzotriazole,99% HOAT 1M DMA solution HOAt USP/EP/BP 39968-33-7/1-Hydroxy-7-azabenzotriazole HOAT (1-Hydroxy-7-azobenzotriazole) pure, 98% 1-Hydroxy-7-azabenzotriazole in DMF(0.6M/L） 1-Hydroxy-7-azabenzotriazole in DMA（1M) HOAt - 0.6M in DMF 1-Hydroxy-7-azabenzotriazol, 0.6 M solution in DMF 1-Hydroxy-7-azabenzotriazole 1M DMA solution 1-HYDROXY-7-AZABENZOTRIAZOLE 99%min HO-EPCP N-Hydroxy-7-azabenzotriazole(HOAT) [1,2,3]Triazolo[4,5-b]pyridin-3-ol 1-Hydroxy-7-azabenzo 1-Hydroxy-7-azabenotriazole 1-Hydroxy-7-azabenzotriazole 3H-[1,2,3]triazolo[4,5-b]pyridin-3-ol(SALTDATA: FREE) 3-hydroxytriazolo[4,5-b]pyridine 39968-33-7 28067-46-8 Synthetic Reagents Coupling Active Esters/Additives Peptide Coupling Reagents PROTECTED AMINO ACID & PEPTIDES Heterocycles Heterocyclic Compounds