JZL 195
- CAS No.
- 1210004-12-8
- Chemical Name:
- JZL 195
- Synonyms
- CS-1586;JZL 195;JZL195 ，S6609;JZL195, 10 mM in DMSO;JZL-195;JZL 195;JZL195;JZL 195 hydrochloride, FAAH/MAGL inhibitor;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester
- CBNumber:
- CB32591530
- Molecular Formula:
- C24H23N3O5
- Molecular Weight:
- 433.46
- MDL Number:
- MFCD18382122
- MOL File:
- 1210004-12-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 581.8±50.0 °C(Predicted) |
|---|---|
| Density | 1.303±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: ≥5mg/mL at warmed |
| form | powder |
| pka | 6.13±0.10(Predicted) |
| color | white to beige |
| InChI | 1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2 |
| InChIKey | QNYRAEKLMNDRFY-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1ccc(OC(=O)N2CCN(CC2)Cc3cccc(Oc4ccccc4)c3)cc1 |
| FDA UNII | TP6P2HKJ54 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
JZL 195 price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0257 | JZL195 ≥98% (HPLC) | 1210004-12-8 | 5mg | $119 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0257 | JZL195 ≥98% (HPLC) | 1210004-12-8 | 25mg | $460 | 2026-04-30 | Buy |
| Cayman Chemical | 13668 | JZL 195 ≥98% | 1210004-12-8 | 5mg | $68 | 2026-04-30 | Buy |
| Cayman Chemical | 13668 | JZL 195 ≥98% | 1210004-12-8 | 10mg | $124 | 2026-04-30 | Buy |
| Cayman Chemical | 13668 | JZL 195 ≥98% | 1210004-12-8 | 50mg | $515 | 2026-04-30 | Buy |
JZL 195 Chemical Properties, Uses, Production
Description
Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-
Uses
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.
in vivo
JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay[1].
| Animal Model: | Male C57BL/6J mice[1] |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone. |
storage
Store at -20°C
References
[1] JONATHAN Z LONG. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 48: 20270-20275. DOI: 10.1073/pnas.0909411106
JZL 195 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| Shanghai DongYang Biotechnology Co., Ltd. | 18657622632 | chemsharker@126.com | China | 371 | 55 |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 645 | 55 |
| ShangHai Siyan Biological Technology Co., Ltd. | 021-50908862，442785678，326799392 18721037013 | siyansales@126.com | China | 9612 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
