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3-(2-chloropyriMidin-4-yl)-1H-indole

3-(2-chloropyriMidin-4-yl)-1H-indole structure

CAS No.: 945016-63-7

Chemical Name:: 3-(2-chloropyriMidin-4-yl)-1H-indole

Synonyms: 3-(2-Chloro-4-pyrimidyl)indole;3-(2-Chloro-4-pyrimidinyl)-1H-indole;3-(2-chloropyriMidin-4-yl)-1H-indole;1H-Indole, 3-(2-chloro-4-pyrimidinyl)-

CBNumber:: CB32595543

Molecular Formula:: C12H8ClN3

Molecular Weight:: 229.66

MDL Number:: MFCD16658942

MOL File:: 945016-63-7.mol

MSDS File:: SDS

Last updated:2026-05-28 01:08:23

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3-(2-chloropyriMidin-4-yl)-1H-indole Properties

storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Appearance	Light yellow to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501

3-(2-chloropyriMidin-4-yl)-1H-indole price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	305963	3-(2-Chloropyrimidin-4-yl)-1H-indole	945016-63-7	1.00g	$95	2026-05-19	Buy
Matrix Scientific	305963	3-(2-Chloropyrimidin-4-yl)-1H-indole	945016-63-7	5.00g	$247	2026-05-19	Buy
Matrix Scientific	305963	3-(2-Chloropyrimidin-4-yl)-1H-indole	945016-63-7	10.00g	$469	2026-05-19	Buy
Synthonix	C26770	3-(2-Chloropyrimidin-4-yl)-1H-indole 97%	945016-63-7	100mg	$26	2026-05-06	Buy
Synthonix	C26770	3-(2-Chloropyrimidin-4-yl)-1H-indole 97%	945016-63-7	250mg	$32	2026-05-06	Buy

Product number	Packaging	Price	Buy
305963	1.00g	$95	Buy
305963	5.00g	$247	Buy
305963	10.00g	$469	Buy
C26770	100mg	$26	Buy
C26770	250mg	$32	Buy

3-(2-chloropyriMidin-4-yl)-1H-indole Chemical Properties, Uses, Production

Uses

2,3,4-Trimethoxybenzaldehyde is an important pharmaceutical intermediate used in the synthesis of novel Ca2+ channel blockers. This drug can selectively target cerebral arteries to reduce the incidence of headaches and has a certain market demand in Europe and the United States. It can also be used as impurity C in trimetazidine, contributing to the standardization process during trimetazidine development. Impurity research is a crucial aspect of drug development.

Application

3-(2-Chloro-pyrimidin-4-yl)-1H-indole can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical synthesis processes.

Synthesis

120-72-9

3934-20-1

945016-63-7

General procedure for the synthesis of 3-(2-chloropyrimidin-4-yl)-1H-indole from indole and 2,4-dichloropyrimidine: 3-(2-chloropyrimidin-4-yl)-1H-indole (1 g, 4.37 mmol), 2-(difluoromethoxy)-4-fluoro-5-nitroaniline (810 mg, 4.37 mmol), and p-toluenesulfonic acid (750 mg, 4.37 mmol) were dissolved in 2-pentanol (40 mL). The reaction mixture was heated and stirred at 110 °C for 3 hours. The progress of the reaction was monitored by LCMS and after confirming the completion of the reaction, the reaction mixture was naturally cooled to room temperature and a dark colored solid was precipitated. The solid was collected by filtration and the filter cake was washed sequentially with methanol and methyl tert-butyl ether to give 3-(2-chloropyrimidin-4-yl)-1H-indole (1.3 g, 79% yield).

References

[1] Patent: EP3205650, 2017, A1. Location in patent: Paragraph 0106; 0512; 0513
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 17, p. 7025 - 7048
[3] Patent: CN105153122, 2018, B. Location in patent: Paragraph 0034; 0117; 0118; 0119; 0120
[4] Patent: WO2013/14448, 2013, A1. Location in patent: Page/Page column 139
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 20, p. 8249 - 8267

3-(2-chloropyriMidin-4-yl)-1H-indole synthesis

Synthesis of 3-(2-chloropyriMidin-4-yl)-1H-indole from Indole and 2,4-Dichloropyrimidine

3-(2-chloropyriMidin-4-yl)-1H-indole Preparation Products And Raw materials

Raw materials

3-(2-chloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole 1-(Phenylsulfonyl)-1H-indol-3-ylboronic acid Pyrimidine, 2-chloro-4-ethynyl- (9CI) Nitrosobenzene 2,4-Dichloropyrimidine

Indole

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Preparation Products

N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine AZ 7550 3-(2-chloropyriMidin-4-yl)-1-Methylindole

3-(2-chloropyriMidin-4-yl)-1H-indole Suppliers

Global Suppliers ( 95)

Supplier	Tel	Email	Country	ProdList	Advantage
Biokitchen	021-021-021-31663258 13795219287	donghuanwen@126.com	China	3080	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Shanghai Sphchem Co., Ltd.	021-56491756 13512199871	2819742715@qq.com	China	3994	55
Heterochem	027-88041443 13072715837	sales@hetero-chem.com	China	695	58
Chiba Pharmaceutical Science and technology Co, Ltd.	0531-81313138 13066006660	chibapharm@foxmail.com	China	3996	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Shanghai YuanQi Biotechnology Co., Ltd.	+86-2332782371 +86-18120098618	sales@adobechem.com	China	1250	50
Suzhou Chenke Biotech Co., Ltd.	18662408853	2120408911@qq.com	China	980	55

Supplier	Advantage
Biokitchen	58
Shanghai Boyle Chemical Co., Ltd.	55
Energy Chemical	61
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Shanghai Sphchem Co., Ltd.	55
Heterochem	58
Chiba Pharmaceutical Science and technology Co, Ltd.	55
Bide Pharmatech Ltd.	60
Shanghai YuanQi Biotechnology Co., Ltd.	50
Suzhou Chenke Biotech Co., Ltd.	55

View Latest Price from 3-(2-chloropyriMidin-4-yl)-1H-indole manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-05-23	3-(2-chloropyriMidin-4-yl)-1H-indole	$150.00	1kg	99%	500kg	Hebei Zhuanglai Chemical Trading Co Ltd
	2019-12-26	3-(2-chloropyriMidin-4-yl)-1H-indole 945016-63-7	$9.80	1g	≥99%	100kg	Career Henan Chemical Co

3-(2-chloropyriMidin-4-yl)-1H-indole
$150.00
99%
Hebei Zhuanglai Chemical Trading Co Ltd

3-(2-chloropyriMidin-4-yl)-1H-indole
945016-63-7
$9.80
≥99%
Career Henan Chemical Co

3-(2-chloropyriMidin-4-yl)-1H-indole Spectrum

3-(2-chloropyriMidin-4-yl)-1H-indole(945016-63-7)¹HNMR

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3-(2-Chloropyrimidin-4-yl)-1-cyclopropyl-1H-indole

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3-(2-chloropyriMidin-4-yl)-1H-indole 3-(2-Chloro-4-pyrimidinyl)-1H-indole 1H-Indole, 3-(2-chloro-4-pyrimidinyl)- 3-(2-Chloro-4-pyrimidyl)indole 945016-63-7