2,4,6-trichloronicotinaldehyde
- CAS No.
- 1261269-66-2
- Chemical Name:
- 2,4,6-trichloronicotinaldehyde
- Synonyms
- 2,4,6-trichloronicotinaldehyde;2,4,6-trichloropyridine-3-carbaldehyde;2,4,6-Trichloropyridine-3-carboxaldehyde;3-Pyridinecarboxaldehyde, 2,4,6-trichloro-
- CBNumber:
- CB32597901
- Molecular Formula:
- C6H2Cl3NO
- Molecular Weight:
- 210.45
- MDL Number:
- MFCD17012148
- MOL File:
- 1261269-66-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,4,6-Trichloronicotinaldehyde | T897660 | 100mg | $175 |
| 2,4,6-Trichloronicotinaldehyde | 7783BB | 250mg | $216 |
| 2,4,6-Trichloronicotinaldehyde | 7783BB | 1g | $435 |
| 2,4,6-Trichloronicotinaldehyde | CS-0047127 | 1g | $455 |
| 2,4,6-TRICHLORONICOTINALDEHYDE 95.00% | HCH0362623 | 5MG | $495.28 |
| Boiling point | 297.5±35.0 °C(Predicted) |
|---|---|
| Density | 1.616±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -4.22±0.10(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C6H2Cl3NO/c7-4-1-5(8)10-6(9)3(4)2-11/h1-2H |
| InChIKey | RESMQRUOHBZJCA-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(Cl)=CC(Cl)=C1C=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
2,4,6-trichloronicotinaldehyde price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T897660 | 2,4,6-Trichloronicotinaldehyde | 1261269-66-2 | 100mg | $175 | 2021-12-16 | Buy |
| AK Scientific | 7783BB | 2,4,6-Trichloronicotinaldehyde | 1261269-66-2 | 250mg | $216 | 2021-12-16 | Buy |
| AK Scientific | 7783BB | 2,4,6-Trichloronicotinaldehyde | 1261269-66-2 | 1g | $435 | 2021-12-16 | Buy |
| ChemScene | CS-0047127 | 2,4,6-Trichloronicotinaldehyde | 1261269-66-2 | 1g | $455 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0362623 | 2,4,6-TRICHLORONICOTINALDEHYDE 95.00% | 1261269-66-2 | 5MG | $495.28 | 2021-12-16 | Buy |
2,4,6-trichloronicotinaldehyde Chemical Properties,Uses,Production
Synthesis
16063-69-7
109-94-4
1261269-66-2
GENERAL STEPS: 2,4,6-Trichloropyridine (5 g, 27.4 mmol) was dissolved in anhydrous THF (100 ml) and the solution was cooled to -78 °C. N-butyllithium (22.27 ml, 28.8 mmol, 1.6 M hexane solution) was slowly added at -78 °C and stirred for 30 min. Subsequently, ethyl formate (10.15 g, 137 mmol) was added, ensuring that the internal temperature was maintained below -74 °C. The reaction mixture was stirred continuously at -78 °C until the feedstock was completely consumed (9:1 unfolding agent ratio of heptane/EtOAc monitored by TLC). Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution (50 ml) and 0.5 N HCl solution at -78 °C. The mixture was warmed to room temperature and extracted with EtOAc. The organic phase was washed with brine, dried over MgSO4 and concentrated. The crude product (light yellow solid) was purified by rapid chromatography on silica gel with 0-20% EtOAc/heptane as eluent to give 5.1 g (88% yield) of the target product 2,4,6-trichloronicotinaldehyde as a white solid.1H NMR (400 MHz, chloroform-d3) δppm= 10.42 (s, 1H), 7.45 (s, 1H).
References
[1] Patent: US2018/111932, 2018, A1. Location in patent: Paragraph 0388; 0389
[2] Patent: US2015/57260, 2015, A1. Location in patent: Paragraph 0765; 0766; 1088; 1089
[3] Patent: WO2015/25026, 2015, A1. Location in patent: Page/Page column 178; 179
[4] Patent: WO2015/25025, 2015, A1. Location in patent: Page/Page column 399
2,4,6-trichloronicotinaldehyde Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2,4,6-trichloronicotinaldehyde Suppliers
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