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N-(3,5-DiMethyladaMantan-1-yl)forMaMide

N-(3,5-DiMethyladaMantan-1-yl)forMaMide structure

CAS No.: 351329-88-9

Chemical Name:: N-(3,5-DiMethyladaMantan-1-yl)forMaMide

Synonyms: MeMantine Related CoMpound E;N-ForMyl MeMantine;Memantine USP RC E;N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)formamide; Adamantane Impurity E;Memantine USP impurity E;Memantine Related Compound 2;N-(3,5-DiMethyladaMantan-1-yl);Memantine USP Related Compound E;1-ForMylaMino-3,5-diMethyladaMantane

CBNumber:: CB32622883

Molecular Formula:: C13H21NO

Molecular Weight:: 207.31

MDL Number:: MFCD01825787

MOL File:: 351329-88-9.mol

MSDS File:: SDS

Last updated:2026-05-28 01:07:54

Product description	Number	Pack Size	Price
N-(3,5-Dimethyladamantan-1-yl)formamide 98%	D57227	100mg	$36
N-(3,5-Dimethyladamantan-1-yl)formamide 98%	D57227	250mg	$80
N-(3,5-Dimethyladamantan-1-yl)formamide 98%	D57227	1g	$200
N-(3,5-Dimethyladamantan-1-yl)formamide 98%	AA0037JP	100mg	$22
N-(3,5-Dimethyladamantan-1-yl)formamide 98%	AA0037JP	250mg	$53
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N-(3,5-DiMethyladaMantan-1-yl)forMaMide Properties

Melting point	69.5℃
Boiling point	325.6±9.0 °C(Predicted)
Density	1.07±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	16.08±0.60(Predicted)
color	White to Off-White
Major Application	pharmaceutical small molecule
InChI	InChI=1S/C13H21NO/c1-11-3-10-4-12(2,6-11)8-13(5-10,7-11)14-9-15/h9-10H,3-8H2,1-2H3,(H,14,15)
InChIKey	NYQWYYMEIBHRSB-UHFFFAOYSA-N
SMILES	C(NC12CC3(C)CC(CC(C)(C3)C1)C2)=O
FDA UNII	6SSG3K6HBR
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P501-P270-P264-P301+P312+P330
WGK Germany	WGK 3
HS Code	2903890002
Storage Class	11 - Combustible Solids

N-(3,5-DiMethyladaMantan-1-yl)forMaMide price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Synthonix	D57227	N-(3,5-Dimethyladamantan-1-yl)formamide 98%	351329-88-9	100mg	$36	2026-05-06	Buy
Synthonix	D57227	N-(3,5-Dimethyladamantan-1-yl)formamide 98%	351329-88-9	250mg	$80	2026-05-06	Buy
Synthonix	D57227	N-(3,5-Dimethyladamantan-1-yl)formamide 98%	351329-88-9	1g	$200	2026-05-06	Buy
aablocks	AA0037JP	N-(3,5-Dimethyladamantan-1-yl)formamide 98%	351329-88-9	100mg	$22	2026-05-28	Buy
aablocks	AA0037JP	N-(3,5-Dimethyladamantan-1-yl)formamide 98%	351329-88-9	250mg	$53	2026-05-28	Buy

Product number	Packaging	Price	Buy
D57227	100mg	$36	Buy
D57227	250mg	$80	Buy
D57227	1g	$200	Buy
AA0037JP	100mg	$22	Buy
AA0037JP	250mg	$53	Buy

N-(3,5-DiMethyladaMantan-1-yl)forMaMide Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

N-Formyl Memantine is an impurity of Memantine (M218000). Memantine impurity E per USP.

Synthesis

941-37-7

77287-34-4

351329-88-9

GENERAL METHOD: To a 17 mL stainless steel pressure microreactor or glass vial under argon protection, 0.3 mmol of manganese-containing catalyst, 10 mmol of 1-bromo-3,5-dimethyladamantane (I), and 30 mmol of formamide were sequentially added. The reaction mixture was heated with stirring at 120-130°C for 3-4 hours. After completion of the reaction, the reactor was cooled to room temperature and opened. The reaction mixture was washed with water and the reaction product was subsequently extracted with 33 mL of dichloromethane. The solvent was removed by distillation under reduced pressure and the residue was purified by recrystallization. Further purification by silica gel column chromatography (eluent: hexane-ethyl acetate mixed solvent) afforded N-(3,5-dimethyladamantan-1-yl)formamide (II). The yield of the product was 78% and the melting point was 69-70°C (hexane recrystallization). Its physicochemical properties and NMR spectral data were in agreement with those reported in the literature [7].

References

[1] Russian Journal of General Chemistry, 2015, vol. 85, # 7, p. 1771 - 1772
[2] Zh. Obshch. Khim., 2015, vol. 85, # 7, p. 1210 - 1211,2
[3] Patent: WO2010/15415, 2010, A1. Location in patent: Page/Page column 16-17
[4] Patent: WO2010/83996, 2010, A1. Location in patent: Page/Page column 20-21

N-(3,5-DiMethyladaMantan-1-yl)forMaMide Preparation Products And Raw materials

Raw materials

1,3-Dimethyladamantane 1-Bromo-3,5-dimethyladamantane formamide

Preparation Products

N-(3,5-DiMethyladaMantan-1-yl)forMaMide Suppliers

Global( 124)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Wuhan Boye Science And Technology Development Co., Ltd.	27-81625225 +8615387090420	sumihu@boyechemicals.com	CHINA	215	58
Henan Yufu New Materials Co.,Ltd		sales@yufluoro.com	China	300	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8645	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58

Supplier	Advantage
Standardpharm Co. Ltd.	58
BOC Sciences	58
career henan chemical co	58
Wuhan Boye Science And Technology Development Co., Ltd.	58
Henan Yufu New Materials Co.,Ltd	58
CR Corporation Limited	58
sgtlifesciences pvt ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Nanjing Doge Biomedical Technology Co., Ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from N-(3,5-DiMethyladaMantan-1-yl)forMaMide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-11-13	N-(3,5-DiMethyladaMantan-1-yl)forMaMide 351329-88-9		100ASSAYS	98%	1tons	Wuhan Boye Science And Technology Development Co., Ltd.
	2020-01-19	N-(3,5-DiMethyladaMantan-1-yl)forMaMide 351329-88-9	$1.00	1KG	99.0%	100kg	Career Henan Chemical Co

N-(3,5-DiMethyladaMantan-1-yl)forMaMide
351329-88-9
$0.00
98%
Wuhan Boye Science And Technology Development Co., Ltd.

N-(3,5-DiMethyladaMantan-1-yl)forMaMide
351329-88-9
$1.00
99.0%
Career Henan Chemical Co

N-(3,5-DiMethyladaMantan-1-yl)forMaMide Spectrum

N-(3,5-DiMethyladaMantan-1-yl)forMaMide(351329-88-9)¹HNMR

351329-88-9(N-(3,5-DiMethyladaMantan-1-yl)forMaMide)Related Search:

Memantine Related Compound 1 Memantine-glucose Adduct 1 1-Bromo-3,5-dimethyladamantane 3-AMINO-5,7-DIMETHYLADAMANTAN-1-OL Hydrochloride Memantine-Galactose Adduct 1

1-Actamido-3,5-dimethyladmantane Memantine Glucuronic Acid Conjugate (Furanose Form) 3,5-DiMethyl-1-nitroadaMantane Tricyclo[3.3.1.13,7]decan-1-aMine, 3,5,7-triMethyl-, hydrochloride Memantine Lactose Adduct

Demethyl Memantine Hydrochloride Memantine

1of3

1-ForMylaMino-3,5-diMethyladaMantane N-(3,5-DiMethyladaMantan-1-yl)forMaMide N-(3,5-DiMethyltricyclo[3.3.1.13,7]dec-1-yl)forMaMide N-ForMyl MeMantine Memantine USP Related Compound E Memantine Related Compound E (15 mg) (N-3,5-Dimethyladamantan-1-yl formamide) Memantine USP RC E Memantine Impurity 5(Memantine USP RC E) N-(3,5-dimethyl-1-adamantyl)formamide N-(3,5-DiMethyladaMantan-1-yl) FORMAMIDE, N-(3,5-DIMETHYLTRICYCLO[3.3.1.13,7]DEC-1-YL)- Memantine Related Compund E (N-3,5-Dimethyladamantan-1-yl formamide) Adamantane Impurity E Memantine Impurity EQ: What is Memantine Impurity E Q: What is the CAS Number of Memantine Impurity E Q: What is the storage condition of Memantine Impurity E Q: What are the applications of Memantine Impurity E Memantine Related Compound E (N-3,5-Dimethyladamantan-1-yl formamide) (1380557) Memantine Related Compound 2 Piperidine,1-(3-chloropropyl)-,hydrochloride(1:3) Memantine Related Compound E N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)formamide Memantine USP impurity E N-(3,5-Dimethyladamantan-1-yl)formamide,98% Memantine EP Impurity G (Memantine USP Related Compound E) USP hydrochloride memantine impurity E MeMantine Related CoMpound E N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)formamide Memantine Hydrochloride Impurity 5 (Memantine USP Related Compound E) 351329-88-9 351329-77-8 Amines Impurities Intermediates & Fine Chemicals Pharmaceuticals