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Glucocorticoid receptor agonist

Glucocorticoid receptor agonist Structure
Glucocorticoid receptor agonist structure
CAS No.
1245526-82-2
Chemical Name:
Glucocorticoid receptor agonist
Synonyms
Glucocorticoid receptor agonist;1H-Pyrrolo[2,3-c]pyridine-2-ethanol, α-[2-(5-fluoro-2-hydroxyphenyl)-2-Methylpropyl]-α-(trifluoroMethyl)-, (αR)-;alpha-[2-(5-Fluoro-2-hydroxyphenyl)-2-methylpropyl]-alpha-(trifluoromethyl)-(alphaR)-1H-pyrrolo[2,3-c]pyridine-2-ethanol;(ALPHAR)-ALPHA-[2-(5-FLUORO-2-HYDROXYPHENYL)-2-METHYLPROPYL]-ALPHA-(TRIFLUOROMETHYL)-1H-PYRROLO[2,3-C]PYRIDINE-2-ETHANOL
CBNumber:
CB32624175
Molecular Formula:
C20H20F4N2O2
Molecular Weight:
396.38
MDL Number:
MOL File:
1245526-82-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-22 18:57:36
Product description Number Pack Size Price
Glucocorticoidreceptoragonist 99.56% CS-0520 5mg $383
Glucocorticoidreceptoragonist A3438 5mg $467
(ALPHAR)-ALPHA-[2-(5-FLUORO-2-HYDROXYPHENYL)-2-METHYLPROPYL]-ALPHA-(TRIFLUOROMETHYL)-1H-PYRROLO-[2,3-C]PYRIDINE-2-ETHANOL 95.00% CCH0012915 5MG $611.6
Glucocorticoidreceptoragonist 99.56% CS-0520 10mg $726
Glucocorticoidreceptoragonist A3438 10mg $886
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Glucocorticoid receptor agonist Properties

Boiling point 563.1±50.0 °C(Predicted)
Density 1.373
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
pka 10.16±0.43(Predicted)
color White to yellow

Glucocorticoid receptor agonist price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0520 Glucocorticoidreceptoragonist 99.56% 1245526-82-2 5mg $383 2021-12-16 Buy
ApexBio Technology A3438 Glucocorticoidreceptoragonist 1245526-82-2 5mg $467 2021-12-16 Buy
American Custom Chemicals Corporation CCH0012915 (ALPHAR)-ALPHA-[2-(5-FLUORO-2-HYDROXYPHENYL)-2-METHYLPROPYL]-ALPHA-(TRIFLUOROMETHYL)-1H-PYRROLO-[2,3-C]PYRIDINE-2-ETHANOL 95.00% 1245526-82-2 5MG $611.6 2021-12-16 Buy
ChemScene CS-0520 Glucocorticoidreceptoragonist 99.56% 1245526-82-2 10mg $726 2021-12-16 Buy
ApexBio Technology A3438 Glucocorticoidreceptoragonist 1245526-82-2 10mg $886 2021-12-16 Buy
Product number Packaging Price Buy
CS-0520 5mg $383 Buy
A3438 5mg $467 Buy
CCH0012915 5MG $611.6 Buy
CS-0520 10mg $726 Buy
A3438 10mg $886 Buy

Glucocorticoid receptor agonist Chemical Properties,Uses,Production

Uses

Glucocorticoid receptor agonist is a Glucocorticoid receptor agonist that acts on Glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR) with the IC50 values of 2.1 , 1200 and 210 nM, respectively. Glucocorticoid receptor agonist has steroid-like anti-inflammatory properties and may be used to improve metabolism and reduce increased levels of body fat and serum insulin[1].

in vivo

Glucocorticoid receptor agonist ((R)-16) exhibits good pharmacokinetic properties in Sprague-Dawley rats[1].
Glucocorticoid receptor agonist ((R)-16) (30 and 10 mg/kg, p.o., daily, 5 weeks) can reduce the increased levels of body fat and serum insulin and shows an effective inhibition of TNF-α production in LPS-stimulated mouse model[1].
The pharmacokinetic parameters of Glucocorticoid receptor agonist ((R)-16) in Sprague-Dawley rat (5 mg/kg i.v. or 30 mg/kg p.o.)[1].

ParametersCl (i.v.)(mL/min/kg)VSS(iv) (L/kg)T1/2(iv)(h)Cmax(po) (ng/mL)AUCinf(po) (h·ng/mL)F(po)%
(R)-16497.61.85509487948

References

[1] Doris Riether, et al. Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics. J Med Chem. 2010 Sep 23;53(18):6681-98. DOI:10.1021/jm100751q

Glucocorticoid receptor agonist Preparation Products And Raw materials

Raw materials

Preparation Products

Glucocorticoid receptor agonist Suppliers

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TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
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TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19957 58
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MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3866 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 		58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		58
Chembest Research Laboratories Limited 61
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
LETOPHARM LIMITED 58
Guangzhou QiYun Biotechnology Co., Ltd. 58

View Lastest Price from Glucocorticoid receptor agonist manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Glucocorticoid receptor agonist pictures 2026-04-22 Glucocorticoid receptor agonist
1245526-82-2
 US $1190.00-1550.00 / mg 10g TargetMol Chemicals Inc.
Glucocorticoid receptor agonist pictures 2025-10-28 Glucocorticoid receptor agonist
1245526-82-2
 US $1190.00-1550.00 / mg 10g TargetMol Chemicals Inc.

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GR (Glucocorticoid receptor)

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1H-Pyrrolo[2,3-c]pyridine-2-ethanol, α-[2-(5-fluoro-2-hydroxyphenyl)-2-Methylpropyl]-α-(trifluoroMethyl)-, (αR)- (ALPHAR)-ALPHA-[2-(5-FLUORO-2-HYDROXYPHENYL)-2-METHYLPROPYL]-ALPHA-(TRIFLUOROMETHYL)-1H-PYRROLO[2,3-C]PYRIDINE-2-ETHANOL Glucocorticoid receptor agonist alpha-[2-(5-Fluoro-2-hydroxyphenyl)-2-methylpropyl]-alpha-(trifluoromethyl)-(alphaR)-1H-pyrrolo[2,3-c]pyridine-2-ethanol 1245526-82-2