5,6,7,8-Tetrahydroquinoline-2-carbonitrile
- CAS No.
- 150459-78-2
- Chemical Name:
- 5,6,7,8-Tetrahydroquinoline-2-carbonitrile
- Synonyms
- 5,6,7,8-Tetrahydroquinoline-2-carbonitrile;2-Quinolinecarbonitrile, 5,6,7,8-tetrahydro-
- CBNumber:
- CB32629574
- Molecular Formula:
- C10H10N2
- Molecular Weight:
- 158.2
- MDL Number:
- MOL File:
- 150459-78-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
5,6,7,8-Tetrahydroquinoline-2-carbonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | AGA45978 | 5,6,7,8-Tetrahydroquinoline-2-carbonitrile | 150459-78-2 | 100mg | $318 | 2026-06-04 | Buy |
| Biosynth | AGA45978 | 5,6,7,8-Tetrahydroquinoline-2-carbonitrile | 150459-78-2 | 1g | $800 | 2026-06-04 | Buy |
| aablocks | AA001MJV | 5,6,7,8-Tetrahydroquinoline-2-carbonitrile 95% | 150459-78-2 | 100mg | $122 | 2026-05-28 | Buy |
| aablocks | AA001MJV | 5,6,7,8-Tetrahydroquinoline-2-carbonitrile 95% | 150459-78-2 | 250mg | $184 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y218057 | 5,6,7,8-tetrahydro-quinoline-2-carbonitrile 97.00% | 150459-78-2 | 250MG | $325 | 2026-05-27 | Buy |
5,6,7,8-Tetrahydroquinoline-2-carbonitrile Chemical Properties, Uses, Production
Synthesis
14631-48-2
7677-24-9
150459-78-2
To a solution of 5,6,7,8-tetrahydro-1-quinoline (10 g, 67 mmol) in dichloromethane (134 mL) was added sequentially trimethylcyanosilane (TMSCN, 18.5 mL, 147.4 mmol) and dimethylcarbamoyl chloride (13.7 mL, 147.4 mmol) at room temperature. The reaction mixture was stirred overnight and then the reaction was quenched with 3M aqueous sodium hydroxide solution (350 mL). The mixture was stirred vigorously for 10 minutes, followed by multiple extractions with dichloromethane (200 mL x 6). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated. The resulting residue was purified by silica gel column chromatography to afford 5,6,7,8-tetrahydro-2-cyanoquinoline (6.5 g, 61% yield).ESI-MS (M + H+) = 159.
References
[1] Patent: WO2008/95058, 2008, A1. Location in patent: Page/Page column 18-19
[2] Patent: EP1424336, 2004, A1. Location in patent: Page 107
[3] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 5, p. 453 - 458
[4] Heterocycles, 2002, vol. 57, # 1, p. 111 - 122
5,6,7,8-Tetrahydroquinoline-2-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
5,6,7,8-Tetrahydroquinoline-2-carbonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| Shanghai Chiral bio-compound co., Ltd. | 021-5068 3667/17749785980/1029026415; 17749785980 | 1029026415@qq.com | China | 4501 | 58 |
| Shanghai Suifu Chemical Technology CO.,LTD. | 33738187 19945655289 | suifuchemical@163.com | China | 500 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-58859352 17714375163 | qzhang@aikonchem.com | China | 15525 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 54996 | 58 |
| Shanghai Sunway Pharmaceutical Technology Co.,Ltd. | 13611835272 13611835272 | mmwang@sunwaypharm.com | China | 44090 | 58 |
| Zhimei (Shandong) Pharmaceutical Technology Co., Ltd | 15966321721 | zhimeiyiyao@163.com | China | 300 | 58 |
| Shanghai Naiys Biological Technology Co., Ltd | 18321139117 | 316441092@qq.con | China | 3193 | 58 |
| Hubei Co-prosperity Medicine Technonlogy Co., Ltd | 2383948258 19172820304 | 2383948258@qq.com | China | 12983 | 58 |
| Hefei Mokai Pharmaceutical Technology Co., Ltd | 18130062233 | 690231469@qq.com | China | 8000 | 58 |
