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ChemicalBook >> CAS DataBase List >>1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid

1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid

1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid Structure
1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid structure
CAS No.
158577-01-6
Chemical Name:
1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid
Synonyms
2-oxo-1-propan-2-ylquinoline-3-carboxylicacid;2-oxo-1-(propan-2-yl)-1,2-dihydroquinoline-3-carboxylic acid;3-Quinolinecarboxylicacid, 1,2-dihydro-1-(1-methylethyl)-2-oxo-
CBNumber:
CB32637795
Molecular Formula:
C13H13NO3
Molecular Weight:
231.25
MDL Number:
MOL File:
158577-01-6.mol
MSDS File:
SDS
Last updated:2026-05-28 01:09:10
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1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid Properties

Melting point 178-180 °C
Boiling point 354.8±41.0 °C(Predicted)
Density 1.288±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 2.35±0.20(Predicted)
Appearance Light yellow to brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth IGA57701 3-Quinolinecarboxylic acid, 1,2-dihydro-1-(1-methylethyl)-2-oxo- 158577-01-6 50mg $297.5 2026-06-04 Buy
Biosynth IGA57701 3-Quinolinecarboxylic acid, 1,2-dihydro-1-(1-methylethyl)-2-oxo- 158577-01-6 0.5g $855.5 2026-06-04 Buy
aablocks AA001Q8B 3-Quinolinecarboxylicacid, 1,2-dihydro-1-(1-methylethyl)-2-oxo- 97% 158577-01-6 100mg $151 2026-05-28 Buy
aablocks AA001Q8B 3-Quinolinecarboxylicacid, 1,2-dihydro-1-(1-methylethyl)-2-oxo- 97% 158577-01-6 250mg $248 2026-05-28 Buy
aablocks AA001Q8B 3-Quinolinecarboxylicacid, 1,2-dihydro-1-(1-methylethyl)-2-oxo- 97% 158577-01-6 1g $622 2026-05-28 Buy
Product number Packaging Price Buy
IGA57701 50mg $297.5 Buy
IGA57701 0.5g $855.5 Buy
AA001Q8B 100mg $151 Buy
AA001Q8B 250mg $248 Buy
AA001Q8B 1g $622 Buy

1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid Chemical Properties, Uses, Production

Synthesis

2,2-Dimethyl-1,3-dioxane-4,6-dione

2033-24-1

Benzaldehyde, 2-[(1-methylethyl)amino]-

103718-15-6

1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid

158577-01-6

The general procedure for the synthesis of 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid from cyclic (sub)isopropyl malonate and 2-isopropylaminobenzaldehyde (CAS:103718-15-6) was as follows: Meldrum acid (2,2-dimethyl-[1,3]dioxane-4,6-dione, 166.9 g, 1.16 mol) was added to a stirring in a solution of 2-isopropylaminobenzaldehyde (105 g, 0.64 mol) in acetic acid. A mixed solution of ethylenediamine (43.0 mL, 0.64 mol) and acetic acid (73.6 mL, 1.29 mol) dissolved in methanol (1 L) was slowly added to the reaction system at 0°C. The reaction was continued at 0°C for a few minutes. The reaction mixture was continued to be stirred at 0 °C for 1 h, then brought to room temperature and stirred overnight. Upon completion of the reaction, the suspension was filtered and the resulting solid was washed with methanol and collected to afford the target product 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (146 g, 98% yield) as an off-white solid. The structure of the product was confirmed by 1H NMR (CDCl3; 300 MHz): δ 1.72 (d, 6H, CH(CH3)2), 5.50 (bs, 1H, CH(CH3)2), 7.44 (t, 1H, ArH), 7.75-7.77 (m, 2H, ArH), 7.82 (d, 1H, ArH), 8.89 (s, 1H, CH).

References

[1] Patent: US2005/228014, 2005, A1. Location in patent: Page/Page column 17
[2] Patent: US2006/100426, 2006, A1. Location in patent: Page/Page column 19
[3] Patent: US2006/100236, 2006, A1. Location in patent: Page/Page column 21
[4] Patent: US2006/199839, 2006, A1. Location in patent: Page/Page column 24
[5] Patent: US2006/229332, 2006, A1. Location in patent: Page/Page column 9

1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid Preparation Products And Raw materials

Raw materials

2,2-Dimethyl-1,3-dioxane-4,6-dione Acetic acid Ethylenediamine Benzaldehyde, 2-?[(1-?methylethyl)?amino]?- Methanol

Preparation Products

1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid Suppliers

Global Suppliers ( 26)
Supplier Tel Email Country ProdList Advantage
AstaTech (Chengdu) Pharma. Co., Ltd. 15928766785 15928766785 wupengcheng@astatech.cn China 1997 55
Shanghai Tombiopharma Chemical Co. Ltd. 13391076197 tombiopharma@163.com China 4986 55
SanoChem (Chengdu) Tech. Co., Ltd. 28-87999436 02887999436 sales@sano-chem.com China 3792 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-58851090 13913916777 sales01@aikonchem.com China 15947 58
Henan Alpha Chemical Co., Ltd. 0371-55055611 18137792234 3957071458@qq.com China 9959 58
Baoji Guokang Healthchem co.,ltd +8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9389 58
AFINE CHEMICALS LIMITED +86-571-85134551 +86-18958018566 info@afinechem.com China 15030 58
Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo 18584079237 312074905@qq.com China 2523 58
Suzhou Chenrui Biotechnology Co. LTD 17625585511 1580084073@qq.com China 992 58
Supplier Advantage
AstaTech (Chengdu) Pharma. Co., Ltd. 55
Shanghai Tombiopharma Chemical Co. Ltd. 55
SanoChem (Chengdu) Tech. Co., Ltd. 55
Amadis Chemical Company Limited 58
Aikon International Limited 58
Henan Alpha Chemical Co., Ltd. 58
Baoji Guokang Healthchem co.,ltd 58
AFINE CHEMICALS LIMITED 58
Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo 58
Suzhou Chenrui Biotechnology Co. LTD 58

View Latest Price from 1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid pictures 2026-08-25 1-Isopropyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid
158577-01-6
 $2.00-6.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

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3-Quinolinecarboxylicacid, 1,2-dihydro-1-(1-methylethyl)-2-oxo- 2-oxo-1-propan-2-ylquinoline-3-carboxylicacid 2-oxo-1-(propan-2-yl)-1,2-dihydroquinoline-3-carboxylic acid 158577-01-6