2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
- CAS No.
- 858474-14-3
- Chemical Name:
- 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
- Synonyms
- NSC23925;NSC-23925;NSC23925 HCl;NSC23925,NSC-23925;2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE;2-(4-Methoxyphenyl)-a-2-piperidinyl-4-quinolinemethanol Dihydrochloride;2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride;4-Quinolinemethanol, 2-(4-methoxyphenyl)-α-2-piperidinyl-, hydrochloride;(2-(4-Methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol dihydrochloride;[2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride
- CBNumber:
- CB32652756
- Molecular Formula:
- C22H25ClN2O2
- Molecular Weight:
- 384.9
- MDL Number:
- MFCD22666390
- MOL File:
- 858474-14-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| NSC23925 ≥98% (HPLC) | SML0372 | 25mg | $266 |
| NSC23925 ≥98% (HPLC) | SML0372 | 5mg | $115 |
| NSC 23925 | 21947 | 1mg | $36 |
| NSC 23925 | 21947 | 5mg | $105 |
| NSC 23925 | 21947 | 10mg | $155 |
| storage temp. | room temp |
|---|---|
| solubility | H2O: soluble5mg/mL (clear solution) |
| form | powder |
| color | white to beige |
| Water Solubility | H2O: 5mg/mL (clear solution) |
| InChI | 1S/C22H24N2O2.2ClH/c1-26-16-11-9-15(10-12-16)21-14-18(17-6-2-3-7-19(17)24-21)22(25)20-8-4-5-13-23-20;;/h2-3,6-7,9-12,14,20,22-23,25H,4-5,8,13H2,1H3;2*1H |
| InChIKey | WGWOQHWZXLGPNG-UHFFFAOYSA-N |
| SMILES | Cl.Cl.COc1ccc(cc1)-c2cc(C(O)C3CCCCN3)c4ccccc4n2 |
| UNSPSC Code | 12161501 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| NFPA 704 |
|
2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0372 | NSC23925 ≥98% (HPLC) | 858474-14-3 | 25mg | $266 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML0372 | NSC23925 ≥98% (HPLC) | 858474-14-3 | 5mg | $115 | 2022-05-15 | Buy |
| Cayman Chemical | 21947 | NSC 23925 | 858474-14-3 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 21947 | NSC 23925 | 858474-14-3 | 5mg | $105 | 2024-03-01 | Buy |
| Cayman Chemical | 21947 | NSC 23925 | 858474-14-3 | 10mg | $155 | 2024-03-01 | Buy |
2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride Chemical Properties,Uses,Production
Description
NSC 23925 is a non-substrate inhibitor of P-glycoprotein (P-gp). It selectively reverses multidrug resistance mediated by P-gp over resistance mediated by multidrug resistance-associated protein 1 (MRP1/ABCC1) or breast cancer resistance protein (BCRP/ABCG2). It resensitizes paclitaxel-resistant SKOV3TR and OVCAR-8TR cells to paclitaxel . NSC 23925 reverses P-gp efflux, increasing the intracellular accumulation of P-gp substrates, including calcein AM in multidrug-resistant SKOV3TR and OVCAR-8TR cells. It prevents paclitaxel-induced overexpression of the P-gp gene MDR1 and P-gp protein level increases in OVCAR-8 cells. It also prevents the development of paclitaxel-induced multidrug resistance in a SKOV3 mouse xenograft model when administered at a dose of 50 mg/kg per day in combination with paclitaxel.
Uses
This molecule shows an ibility to inhibit plasma membrane glycoprotein 1 (Pgp1) in order to counter and even reverse multi-drug resistance (MDR1) in patients diagnosed with cancer.
in vivo
Both saline alone and NSC23925 alone treated tumors grow progressively. The usage of NSC23925 in paclitaxel chemotherapy significantly prolongs anticancer efficacy of paclitaxel[1].
References
[1] ZHENFENG DUAN Francis J H Edwin Choy. NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance.[J]. PLoS ONE, 2009: e7415. DOI: 10.1371/journal.pone.0007415
[2] XIAOQIAN YANG . NSC23925 prevents the emergence of multidrug resistance in ovarian cancer in vitro and in vivo[J]. Gynecologic oncology, 2015, 137 1: Pages 134-142. DOI: 10.1016/j.ygyno.2015.02.002
2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 18101056239 | 3193328036@qq.com | China | 29661 | 68 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
