tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
- CAS No.
- 1035235-26-7
- Chemical Name:
- tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
- Synonyms
- tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carbo;tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxyl;tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate;2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1;tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-1H-isoquinoline-2-carboxylate;tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate;2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB32665376
- Molecular Formula:
- C20H30BNO4
- Molecular Weight:
- 359.27
- MDL Number:
- MFCD11044677
- MOL File:
- 1035235-26-7.mol
| Product description | Number | Pack Size | Price |
| 2(1H)-Isoquinolinecarboxylicacid,3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-,1,1-dimethylethylester | I917988 | 250mg | $510 |
| tert-Butyl5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate | 0849AA | 1g | $251 |
| TERT-BUTYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 95.00% | BOR0005955 | 5MG | $495.75 |
| tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+% | P000231494 | 100mg | $48 |
| tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+% | P000231494 | 250mg | $83 |
tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | I917988 | 2(1H)-Isoquinolinecarboxylicacid,3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-,1,1-dimethylethylester | 1035235-26-7 | 250mg | $510 | 2021-12-16 | Buy |
| AK Scientific | 0849AA | tert-Butyl5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate | 1035235-26-7 | 1g | $251 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BOR0005955 | TERT-BUTYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 95.00% | 1035235-26-7 | 5MG | $495.75 | 2021-12-16 | Buy |
| Ark Pharm | P000231494 | tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+% | 1035235-26-7 | 100mg | $48 | 2021-12-16 | Buy |
| Ark Pharm | P000231494 | tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+% | 1035235-26-7 | 250mg | $83 | 2021-12-16 | Buy |
tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate Chemical Properties,Uses,Production
Synthesis
215184-78-4
73183-34-3
1035235-26-7
Using N-Boc-5-bromo-1,2,3,4-tetrahydroisoquinoline (2.7 g, 8.7 mmol) and pinacol ester of bisboronic acid (4.39 g, 17 mmol) as the starting material, the reactants were mixed with potassium acetate (2.55 g, 26 mmol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (0.63 g, 0.87 mmol) under the protection of nitrogen. 0.87 mmol) were mixed in 1,4-dioxane (40 mL). The reaction mixture was stirred at 80 °C for 2 h and then cooled to room temperature. Water (30 mL) was added and extracted with ethyl acetate (3 x 20 mL). The organic phases were combined and concentrated under reduced pressure. The residue was purified by fast chromatography (eluent: cyclohexane/ethyl acetate=85:15) to afford the target product tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate as a clear gel (3.25 g, 105% yield).LCMS (formate method) : Retention time 1.51 min, [M+H]+=360.
References
[1] Patent: WO2010/146105, 2010, A1. Location in patent: Page/Page column 86-87
[2] Patent: WO2016/65222, 2016, A1. Location in patent: Page/Page column 57
[3] Patent: WO2010/145202, 2010, A1. Location in patent: Page/Page column 38
[4] Patent: WO2013/134518, 2013, A1. Location in patent: Page/Page column 39
[5] Patent: WO2016/44666, 2016, A1. Location in patent: Paragraph 0589; 0591
tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-Butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 17321281695 18019252918 | sale@amkchem.com | China | 15114 | 55 |
