ChemicalBook >> CAS DataBase List >>Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate structure

CAS No.: 625115-52-8

Chemical Name:: Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate

Synonyms: Desmethyl Riociguat;Riociguat EP Impurity A;Nelociguat;BAY 60-4552;Riociguat-4;13C,D6-Riociguat;Riociguat ImpurityK1;N-Desmethyl Riociguat;methyl (4,6-diamino-2;Riociguat Impurity NK1

CBNumber:: CB32668342

Molecular Formula:: C19H17FN8O2

Molecular Weight:: 408.39

MDL Number:: MFCD22741546

MOL File:: 625115-52-8.mol

MSDS File:: SDS

Last updated:2026-06-06 22:25:17

Product description	Number	Pack Size	Price
Nelociguat ≥95%	34133	5mg	$95
Nelociguat ≥95%	34133	10mg	$168
Nelociguat ≥95%	34133	25mg	$279
Nelociguat ≥95%	34133	50mg	$417
N-Desmethyl Riociguat	TRC-D293285-50MG	50mg	$304
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Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Properties

Melting point	>196oC (dec.)
Boiling point	533.3±50.0 °C(Predicted)
Density	1.58±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
pka	10.68±0.70(Predicted)
form	Solid
color	Light Brown
FDA UNII	M2A18LL56O

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

NFPA 704

	0
2		0

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	34133	Nelociguat ≥95%	625115-52-8	5mg	$95	2026-04-30	Buy
Cayman Chemical	34133	Nelociguat ≥95%	625115-52-8	10mg	$168	2026-04-30	Buy
Cayman Chemical	34133	Nelociguat ≥95%	625115-52-8	25mg	$279	2026-04-30	Buy
Cayman Chemical	34133	Nelociguat ≥95%	625115-52-8	50mg	$417	2026-04-30	Buy
TRC	TRC-D293285-50MG	N-Desmethyl Riociguat	625115-52-8	50mg	$304	2026-06-03	Buy

Product number	Packaging	Price	Buy
34133	5mg	$95	Buy
34133	10mg	$168	Buy
34133	25mg	$279	Buy
34133	50mg	$417	Buy
TRC-D293285-50MG	50mg	$304	Buy

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Chemical Properties,Uses,Production

Uses

N-Desmethyl-riociguat, is a complex that is part affiliated with potent oral stimulator for the treatment of pulmonary hypertension.

Definition

ChEBI: Nelociguat is a member of the class of pyrazolopyridines that is 1H-pyrazolo[3,4-b]pyridine which is substituted by a 2-fluorobenzyl and 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl groups at positions 1 and 3, respectively. It is an active metabolite of riociguat and a soluble guanylate cyclase stimulator developed by Bayer for the treatment of erectile dysfunction and heart failure. It has a role as a soluble guanylate cyclase activator, an antihypertensive agent, a drug metabolite and a vasodilator agent. It is a pyrazolopyridine, a member of monofluorobenzenes, a carbamate ester and an aminopyrimidine.

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Suppliers

Global( 134)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zison Pharmaceutical (Shandong) Co., Ltd.	+86-0086-531-88259693 +86-18660188356	tracy.li@zisonpharm.com	China	88	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29792	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32468	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29093	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3148	58
sgtlifesciences pvt ltd	+91-8790379245	dj@sgtlifesciences.com	China	12373	58

Supplier	Advantage
Zison Pharmaceutical (Shandong) Co., Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
HaBo Hong Kong Co., Limited.	58
Standardpharm Co. Ltd.	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Hefei Hirisun Pharmatech Co., Ltd	58
Hangzhou Huarong Pharm Co., Ltd.	58
sgtlifesciences pvt ltd	58

View Lastest Price from Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate 625115-52-8		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2026-06-06	Nelociguat 625115-52-8	$36.00-79.00		99.19%	10g	TargetMol Chemicals Inc.
2025-12-15	Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate 625115-52-8		1kg	98%	100kgs	Zison Pharmaceutical (Shandong) Co., Ltd.

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate
625115-52-8
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

Nelociguat
625115-52-8
$36.00-79.00
99.19%
TargetMol Chemicals Inc.

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate
625115-52-8
$0.00
98%
Zison Pharmaceutical (Shandong) Co., Ltd.

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Spectrum

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate(625115-52-8)¹HNMR

625115-52-8(Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate)Related Search:

Riociguat Impurtiy 6 Riociguat Impurity 18 Riociguat Impurity 16 2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-N5,N5- dimethylpyrimidine-4,5,6-triamine 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxaMide

Methyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbiMidate 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl) -7-methyl-7,9-dihydro-8H-purin-8-one isopropyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b] pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)- 7,9-dimethyl-7,9-dihydro-8H-purin-8-one BENZENEAZOMALONONITRILE

methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b] pyridin-3-yl)pyrimidin-5-yl)(ethyl)carbamate 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid 1-(3-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)- 7,9-dihydro-8H-purin-8-one

Riociguat 4,6-PyriMidinediaMine, 2-[1-[(2-fluorophenyl)Methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(phenylazo)- 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine

1of4

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester N-Desmethyl Riociguat BAY 60-4552 Nelociguat methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate Riociguat N-Desmethyl Impurity methyl (4,6-diamino-2 N-Desmethyl Riociguat/Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate Riociguat Impurity NK1 Name: Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Riociguat-4 Riociguat Impurity 19/N-Desmethyl Riociguat/Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate Desmethyl RiociguatQ: What is Desmethyl Riociguat Q: What is the CAS Number of Desmethyl Riociguat Q: What is the storage condition of Desmethyl Riociguat Q: What are the applications of Desmethyl Riociguat Carbamic acid,[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester inhibit,Inhibitor,Guanylate Cyclase,Nelociguat methyl [(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)amino]methanoate Riociguat EP Impurity A (N-Desmethyl Riociguat) Riociguat EP Impurity 4 Riociguat ImpurityK1 Nelociguat, 10 mM in DMSO Methyl [4,6-Diamino-2-[1-(2-fluorobenzyl)pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]carbamate 13C,D6-Riociguat 13C, D3-N-desmethyl-Riociguat Desmethyl Riociguat Riociguat EP Impurity A LeoSquare EP Impurity A N-desmethylleocisplatin 625115-52-8 C19H17FN8O2