Quinoxaline, 2-chloro-7-fluoro-
- CAS No.
- 1233932-59-6
- Chemical Name:
- Quinoxaline, 2-chloro-7-fluoro-
- Synonyms
- 2-chloro-7-fluoroquinoxaline;Quinoxaline, 2-chloro-7-fluoro-
- CBNumber:
- CB32681990
- Molecular Formula:
- C8H4ClFN2
- Molecular Weight:
- 182.58
- MDL Number:
- MOL File:
- 1233932-59-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Quinoxaline, 2-chloro-7-fluoro- price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 221418 | 2-Chloro-7-fluoroquinoxaline | 1233932-59-6 | 1.00g | $777 | 2026-05-18 | Buy |
| Matrix Scientific | 221418 | 2-Chloro-7-fluoroquinoxaline | 1233932-59-6 | 5.00g | $2720 | 2026-05-18 | Buy |
| ACHEMBLOCK | T93030 | 2-chloro-7-fluoroquinoxaline 95% | 1233932-59-6 | 250MG | $200 | 2026-05-27 | Buy |
| ACHEMBLOCK | T93030 | 2-chloro-7-fluoroquinoxaline 95% | 1233932-59-6 | 1G | $560 | 2026-05-27 | Buy |
| ACHEMBLOCK | T93030 | 2-chloro-7-fluoroquinoxaline 95% | 1233932-59-6 | 5G | $2240 | 2026-05-27 | Buy |
Quinoxaline, 2-chloro-7-fluoro- Chemical Properties, Uses, Production
Synthesis
145323-53-1
1233932-59-6
Synthesis of 2-chloro-7-fluoroquinoxaline: 7-fluoroquinolin-2(1H)-one (2.60 g, 15.84 mmol, 1.0 eq.) was mixed with phosphorochloridic acid chloride (50 mL, 536.4 mmol, 34.0 eq.) and the reaction was carried out at reflux for 1 hour. Upon completion of the reaction, the mixture was concentrated, diluted with water (60 mL) and the pH was adjusted with saturated aqueous sodium bicarbonate to 7. Subsequently, the reaction mixture was extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by column chromatography (silica gel, eluent: ethyl acetate/petroleum ether, 1:20, v/v) to afford 2-chloro-7-fluoroquinoxaline as a white solid (2.50 g, 84% yield).1H-NMR (400 MHz, DMSO-d6) δ ppm: 8.98 (s, 1H), 8.22 (dd, J = 2.0, 8.8 Hz, 1H ), 7.81-7.89 (m, 2H). ms m/z (+EI): 183.0 [M + H]+.
References
[1] Patent: WO2010/84152, 2010, A1. Location in patent: Page/Page column 55
Quinoxaline, 2-chloro-7-fluoro- Preparation Products And Raw materials
Quinoxaline, 2-chloro-7-fluoro- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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