5-nitro-2-(trifluoroMethyl)pyridin-4-ol
- CAS No.
- 438554-44-0
- Chemical Name:
- 5-nitro-2-(trifluoroMethyl)pyridin-4-ol
- Synonyms
- )-5-nitropyridin-4-oL;2-(trifluoromethyl)-5-nitropyridin-4-ol;5-Nitro-2-(trifluoromethyl)-4-pyridinol;5-nitro-2-(trifluoroMethyl)pyridin-4-ol;4-Pyridinol, 5-nitro-2-(trifluoromethyl)-;5-nitro-2-(trifluoromethyl)-1H-pyridin-4-one;5-nitro-2-(trifluoromethyl)pyridin-4-ol(WXC01771);5-nitro-2-(trifluoromethyl)-1,4-dihydropyridin-4-one
- CBNumber:
- CB32685695
- Molecular Formula:
- C6H3F3N2O3
- Molecular Weight:
- 208.09
- MDL Number:
- MOL File:
- 438554-44-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Nitro-2-(trifluoromethyl)pyridin-4-ol | NSA55444 | 0.5g | $330.4 |
| 5-Nitro-2-(trifluoromethyl)pyridin-4-ol | NSA55444 | 5g | $1298 |
| 2-(Trifluoromethyl)-5-nitropyridin-4-ol | 219435 | 250.00mg | $84 |
| 2-(Trifluoromethyl)-5-nitropyridin-4-ol | 219435 | 1.00g | $145 |
| 2-(Trifluoromethyl)-5-nitropyridin-4-ol | 219435 | 5.00g | $663 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
5-nitro-2-(trifluoroMethyl)pyridin-4-ol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | NSA55444 | 5-Nitro-2-(trifluoromethyl)pyridin-4-ol | 438554-44-0 | 0.5g | $330.4 | 2026-06-04 | Buy |
| Biosynth | NSA55444 | 5-Nitro-2-(trifluoromethyl)pyridin-4-ol | 438554-44-0 | 5g | $1298 | 2026-06-04 | Buy |
| Matrix Scientific | 219435 | 2-(Trifluoromethyl)-5-nitropyridin-4-ol | 438554-44-0 | 250.00mg | $84 | 2026-05-18 | Buy |
| Matrix Scientific | 219435 | 2-(Trifluoromethyl)-5-nitropyridin-4-ol | 438554-44-0 | 1.00g | $145 | 2026-05-18 | Buy |
| Matrix Scientific | 219435 | 2-(Trifluoromethyl)-5-nitropyridin-4-ol | 438554-44-0 | 5.00g | $663 | 2026-05-18 | Buy |
5-nitro-2-(trifluoroMethyl)pyridin-4-ol Chemical Properties,Uses,Production
Synthesis
170886-13-2
438554-44-0
General procedure for the synthesis of 5-nitro-2-(trifluoromethyl)pyridin-4-ol from 2-trifluoromethyl-4-hydroxypyridine: Nitric acid (12 mL) was added slowly and dropwise to a solution of 2-(trifluoromethyl)pyridin-4-ol (10 g, 11.9 mmol) in concentrated sulfuric acid (4.8 mL) under ice bath cooling conditions. The reaction mixture was transferred to a sealed tube and stirred at 120°C for 48 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was cooled to room temperature. The reaction was quenched with ice water and subsequently extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the brown solid product 5-nitro-2-(trifluoromethyl)pyridin-4-ol. Yield: 3.0 g (23% yield). Product characterization data: 1H NMR (400 MHz, DMSO-d6) δ 9.08 (s,1H), 7.43 (s,1H); mass spectrum (ESI+) m/z 208.98 [M+H]+.
References
[1] Patent: WO2006/65703, 2006, A1. Location in patent: Page/Page column 108
[2] Patent: WO2018/37223, 2018, A1. Location in patent: Page/Page column 106; 185; 186; 187; 193; 194
[3] Patent: US2003/69257, 2003, A1
5-nitro-2-(trifluoroMethyl)pyridin-4-ol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +8618118463618 | sales1@artkmedchem.com | China | 39021 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
| Bellen Chemistry Co., Ltd. | 010-60400365-8001 15910885229 | service@bellenchem.com | China | 4514 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31553 | 55 |
| Nanijing m&m biotechnology Co. ,Ltd. | 025-87782433 18021532344 | 1345332203@qq.com | China | 4180 | 58 |
| Changzhou Ditong chemical Co.,Ltd. | 0519-88298848 18118010980 | info@edengenechem.com | China | 785 | 58 |
