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(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate structure

CAS No.: 870281-85-9

Chemical Name:: (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate

Synonyms: CAL-101(N-2);idelalisib N-2;Carbamic acid,[(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2...;(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate;tert-butyl (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate;(S)-[1-(5-FLUORO-4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YL)-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER;(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate(CAL101 N-2 step);[(1S)-1-(5-Fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]carbamic acid 1,1-dimethylethyl ester;Carbamic acid,[(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]-,1,1-dimethylethyl ester;Carbamic acid, [(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]-, 1,1-dimethylethyl ester (9CI)

CBNumber:: CB32686182

Molecular Formula:: C22H24FN3O3

Molecular Weight:: 397.44

MDL Number:: MFCD28134524

MOL File:: 870281-85-9.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:49

Product description	Number	Pack Size	Price
(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate >98%	B60670	10g	$100
(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate >98%	B60670	25g	$260
tert-Butyl(1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2(1H)-ylidene)propyl)carbamate	B809786	500mg	$95
(S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate	9994AL	25g	$1071
(S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate	9994AL	5g	$390
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Request For Quotation

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate Properties

Density	1.21±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	11.39±0.46(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Synthonix	B60670	(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate >98%	870281-85-9	10g	$100	2026-05-06	Buy
Synthonix	B60670	(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate >98%	870281-85-9	25g	$260	2026-05-06	Buy
TRC	B809786	tert-Butyl(1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2(1H)-ylidene)propyl)carbamate	870281-85-9	500mg	$95	2021-12-16	Buy
AK Scientific	9994AL	(S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate	870281-85-9	25g	$1071	2021-12-16	Buy
AK Scientific	9994AL	(S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate	870281-85-9	5g	$390	2021-12-16	Buy

Product number	Packaging	Price	Buy
B60670	10g	$100	Buy
B60670	25g	$260	Buy
B809786	500mg	$95	Buy
9994AL	25g	$1071	Buy
9994AL	5g	$390	Buy

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate Chemical Properties,Uses,Production

Uses

tert-Butyl (1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2(1H)-ylidene)propyl)carbamate is a reagent used in the discovery of a phosphoinositide 3-kinase (PI3K) b/d inhibitor for treatment of phosphatase and tensin homolog (PTEN) deficient tumors.

Synthesis

(S)-([1-(2-fluoro-6-nitro-benzoyl)-phenyl-aMinocarbonyl]-propyl)-carbaMic acid tert-butyl ester

870281-84-8

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate

870281-85-9

3. Preparation of tert-butyl (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate In a 200 mL reaction flask, compound (V) (8.9 g, 0.02 mol) was dissolved in 100 mL acetic acid and stirred until completely dissolved. Zinc powder (9.1 g, 0.14 mol) was added to the reaction system in batches, the reaction temperature was controlled at 25°C and stirring was continued for 3 hours. Upon completion of the reaction, the reaction mixture was collected by vacuum filtration and the filter cake was washed with acetic acid (50 mL). The filtrate was concentrated and the filter cake was washed with dichloromethane (100 mL) and water (50 mL). Subsequently, the aqueous layer was extracted with dichloromethane (50 mL) and the organic phases were combined and washed sequentially with saturated sodium carbonate solution (50 mL) and saturated brine (50 mL). The organic layer was dried with anhydrous magnesium sulfate and concentrated to give the white solid compound (VI), i.e., tert-butyl (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate (6.2 g) in 78% yield and 95% purity.

References

[1] Patent: CN104130261, 2016, B. Location in patent: Paragraph 0055; 0056; 0057; 0058
[2] Patent: WO2005/113554, 2005, A2. Location in patent: Page/Page column 24-25; 27-28
[3] Organic Preparations and Procedures International, 2016, vol. 48, # 4, p. 337 - 341
[4] Patent: WO2016/108206, 2016, A2. Location in patent: Page/Page column 47; 48
[5] RSC Advances, 2018, vol. 8, # 28, p. 15863 - 15869

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate Preparation Products And Raw materials

Raw materials

(S)-([1-(2-fluoro-6-nitro-benzoyl)-phenyl-aMinocarbonyl]-propyl)-carbaMic acid tert-butyl ester

Preparation Products

(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate Suppliers

Global( 92)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30225	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8667	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15078	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Alchem Pharmtech,Inc.	58
Shanghai Yingrui Biopharma Co.,Ltd	58
Antai Fine Chemical Technology Co.,Limited	58
Career Henan Chemica Co	58
Shanghai UCHEM Inc.	58
AFINE CHEMICALS LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-30	(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate 870281-85-9	US $0.00-0.00 / KG	1KG	99%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2025-04-04	(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate 870281-85-9	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	MLN9708 870281-85-9	US $1.00 / kg	1kg	95%-99%	100kg	Career Henan Chemical Co

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
870281-85-9
US $0.00-0.00 / KG
99%
Shenzhen Nexcon Pharmatechs Ltd.

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
870281-85-9
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

MLN9708
870281-85-9
US $1.00 / kg
95%-99%
Career Henan Chemical Co

870281-85-9((S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate)Related Search:

2-Amino-6-fluorobenzoic acid (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one BOC-ABU-OH CAL-101 2-Fluoro-6-nitro-N-phenylbenzamide

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate(CAL101 N-2 step) tert-butyl (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate, [(1S)-1-(5-Fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]carbamic acid 1,1-dimethylethyl ester idelalisib N-2 [(1S)-1-(5-Fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]carbamic acid 1,1-dimethylethyl ester (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate (S)-[1-(5-FLUORO-4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YL)-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER Carbamic acid,[(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]-,1,1-dimethylethyl ester CAL-101(N-2) Carbamic acid, [(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]-, 1,1-dimethylethyl ester (9CI) Carbamic acid,[(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2... 870281-85-9