SG2057
- CAS No.
- 260417-62-7
- Chemical Name:
- SG2057
- Synonyms
- SG2057;5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 8,8'-[1,5-pentanediylbis(oxy)]bis[1,2,3,11a-tetrahydro-7-methoxy-2-methylene-, (11aS,11'aS)-
- CBNumber:
- CB32731136
- Molecular Formula:
- C33H36N4O6
- Molecular Weight:
- 584.66
- MDL Number:
- MOL File:
- 260417-62-7.mol
| form | Solid |
|---|---|
| color | White to light yellow |
| FDA UNII | V23HY4W8OB |
SG2057 Chemical Properties,Uses,Production
Uses
SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent[1].
in vivo
SG2057 (5-60 μg/kg; i.v) exhibits dose-dependent antitumor activity in human tumor xenograft models[1].
| Animal Model: | Female NCr-nude mice injected with SKOV-3 cells[1] |
| Dosage: | 5 μg/kg, 10 μg/kg, 20 μg/kg, 30 μg/kg, 40 μg/kg, 50 μg/kg, 60 μg/kg |
| Administration: | i.v.; daily, once a week, or once every four days |
| Result: | Showed significant antitumor activity. |
IC 50
Pyrrolobenzodiazepines
References
[1] John A Hartley, et al. DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057. Invest New Drugs. 2012 Jun;30(3):950-8. DOI:10.1007/s10637-011-9647-z
SG2057 Preparation Products And Raw materials
Raw materials
Preparation Products
SG2057 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemExpress | +86-19370970350 +86-021-58950125 | info@chemexpress.com | China | 787 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19961 | 58 |
| Shanghai Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 819 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988968278 | YN_research@163.com | China | 3003 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59102966 18717199209 | 2853877583@qq.com | China | 2553 | 58 |
| Suzhou Haiben Pharmaceutical Co., Ltd | 19353112242 | 1816280386@qq.com | China | 8045 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29547 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | 2851167782@qq.com | China | 11146 | 58 |
