4-Chloro-2,6-diMethylquinazoline
- CAS No.
- 1429782-21-7
- Chemical Name:
- 4-Chloro-2,6-diMethylquinazoline
- Synonyms
- 4-Chloro-2,6-diMethylquinazoline;Quinazoline, 4-chloro-2,6-dimethyl-
- CBNumber:
- CB32732229
- Molecular Formula:
- C10H9ClN2
- Molecular Weight:
- 192.64
- MDL Number:
- MFCD22397500
- MOL File:
- 1429782-21-7.mol
| Product description | Number | Pack Size | Price |
| 4-Chloro-2,6-dimethylquinazoline | 292051 | 250.00mg | $66 |
| 4-Chloro-2,6-dimethylquinazoline | 292051 | 1.00g | $80 |
| 4-Chloro-2,6-dimethylquinazoline | 292051 | 5.00g | $378 |
| 4-Chloro-2,6-dimethylquinazoline 95+% | C53846 | 100mg | $51 |
| 4-Chloro-2,6-dimethylquinazoline 95+% | C53846 | 250mg | $60 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H320-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
4-Chloro-2,6-diMethylquinazoline price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 292051 | 4-Chloro-2,6-dimethylquinazoline | 1429782-21-7 | 250.00mg | $66 | 2026-05-19 | Buy |
| Matrix Scientific | 292051 | 4-Chloro-2,6-dimethylquinazoline | 1429782-21-7 | 1.00g | $80 | 2026-05-19 | Buy |
| Matrix Scientific | 292051 | 4-Chloro-2,6-dimethylquinazoline | 1429782-21-7 | 5.00g | $378 | 2026-05-19 | Buy |
| Synthonix | C53846 | 4-Chloro-2,6-dimethylquinazoline 95+% | 1429782-21-7 | 100mg | $51 | 2026-05-06 | Buy |
| Synthonix | C53846 | 4-Chloro-2,6-dimethylquinazoline 95+% | 1429782-21-7 | 250mg | $60 | 2026-05-06 | Buy |
4-Chloro-2,6-diMethylquinazoline Chemical Properties,Uses,Production
Synthesis
18731-19-6
1429782-21-7
General procedure for the synthesis of 4-chloro-2,6-dimethylquinazolines from 2,6-dimethylquinazolin-4(1H)-ones: 1. Synthesis of 4-chloro-6-methyl-2-methylquinazoline: 2,6-dimethylquinazolin-4(1H)-one (5 g, 32 mmol) was dissolved in acetic anhydride (25 mL) and heated at reflux for 12 hours. After completion of the reaction, the mixture was concentrated to give a solid. The solid was dissolved in a mixture of ethanol (50 mL) and ammonia (50 mL) and stirred at 80 °C for 5 hours. The progress of the reaction was monitored by TLC (Spreader: EtOAc/PE = 1:1) and after confirming the consumption of raw materials and the appearance of new spots, the reaction mixture was cooled to room temperature, filtered and the filter cake was collected to afford 4-chloro-6-methyl-2-methyl quinazoline (3.5 g, yield: 60.9%). 2. Synthesis of 4-chloro-2,6-dimethylquinazoline: 4-chloro-6-methyl-2-methylquinazoline (7 g, 40 mmol) was dissolved in toluene (70 mL), N,N-diisopropylethylamine (DIPEA, 10.3 g, 80 mmol) and phosphorus oxychloride (POCl3, 10.4 g, 64 mmol) were added. The mixture was stirred at 80 °C for 4 hours. The progress of the reaction was monitored by TLC (unfolding agent: PE/EtOAc = 3:1) and after confirming the consumption of raw materials and the appearance of new spots, the reaction mixture was concentrated. The crude product was purified by silica gel column chromatography (eluent: PE/EtOAc = 20:1) to afford the target compound 4-chloro-2,6-dimethylquinazoline (5 g, yield: 64.7%) as a white solid. 1H NMR (CDCl3, 400 MHz): δ = 7.94 (s, 1H), 7.84 (d, J = 8.8 Hz, 1H), 7.72 (m, J = 10.8 Hz, 1H), 2.81 (s, 3H), 2.55 (s, 3H).
References
[1] Patent: WO2013/50527, 2013, A1. Location in patent: Page/Page column 58; 59
4-Chloro-2,6-diMethylquinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-2,6-diMethylquinazoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3979 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 17321281695 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4976 | 55 |
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Taizhou Nanfeng Pharmaceutical Research Institute | nanfengpharma@126.co 18616377689 | nanfengpharma@126.com | China | 20008 | 58 |
