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ChemicalBook >> CAS DataBase List >>N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride

N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride

N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride Structure
N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride structure
CAS No.
1215703-04-0
Chemical Name:
N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride
Synonyms
BMS182874;BMS-182874 hydrochloride >=98% (HPLC);BMS 182874 hydrochloride, 10 mM in DMSO;5-(dimethylamino)-N-(3,4-dimethylisoxazol-5-yl)naphthalene-1-sulfonamide hydrochloride;N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride
CBNumber:
CB32750685
Molecular Formula:
C17H20ClN3O3S
Molecular Weight:
381.88
MDL Number:
MOL File:
1215703-04-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride Properties

storage temp. 2-8°C
solubility DMSO: soluble5mg/mL, clear (warmed)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3

N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0708 BMS-182874 hydrochloride ≥98% (HPLC) 1215703-04-0 5mg $106 2022-05-15 Buy
Sigma-Aldrich SML0708 BMS-182874 hydrochloride ≥98% (HPLC) 1215703-04-0 25mg $416 2022-05-15 Buy
Usbiological 443054 BMS 182874 Hydrochloride 1215703-04-0 1mg $368 2026-06-03 Buy
Usbiological 443054 BMS 182874 Hydrochloride 1215703-04-0 2.5mg $602 2026-06-03 Buy
Biosynth QYB70304 BMS-182874 hydrochloride 1215703-04-0 25mg $854.25 2026-06-04 Buy
Product number Packaging Price Buy
SML0708 5mg $106 Buy
SML0708 25mg $416 Buy
443054 1mg $368 Buy
443054 2.5mg $602 Buy
QYB70304 25mg $854.25 Buy

N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride Chemical Properties, Uses, Production

Uses

BMS 182874 hydrochloride is an orallyactive, highly selective endothelin receptor (ETA receptor) antagonist, with IC50 value of 0.150 μM, Ki of 0.055 μM. BMS 182874 hydrochloride reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research[1].

Biological Activity

ki: 61 nm for eta in vsm-a10 cells; 48 nm for eta in cho cellsendothelin (et) was originally identified as a potent vasoactive substance secreted by endothelial cells that stimulated force development in isolated pig coronary arteries. et-1 belongs to a family of highly conserved 21-amino-acid peptides produced in numerous tissues including the lung, kidney, eye, gut and central nervous system. bms-182874 is a low molecular weight, nonpeptide endothelin (el) receptor antagonist.

in vitro

bms-182874 competitively inhibited the binding of [125i]et-1 to eta receptors in rat vascular smooth muscle a10 (vsm-a10) cell membranes (ki = 61 nm) and in cho cells stably expressing the human eta receptor (ki = 48 nm), but was a weak inhibitor at etb receptors (ki > 50 μm) and non-et receptors. bms-l 82874 inhibited et-l -stimulated inositol phosphate accumulation (kb 75 nm) and calcium mobilization (ki = 140 nm) without suppressing the maximal responses in vsm-a10 cells [1].

in vivo

when administered either orally (ed50 = 30 μmol/kg) or intravenously (ed50 = 24 μmol/kg) to conscious, normotensive rats, bms-182874 blunted the pressor response to exogenous et-l . these data demonstrate that bms-l 82874 is a competitive, selective and orally active eta receptor antagonist [1].

References

[1] maria l webb, j. eileen bird, eddie c. k. liu, patricia m. rose, randy serafino, philip d. stein and suzanne moreland. bms-182874 is a selective, nonpeptide endothelin eta receptor antagonist. jpet 272:1124-1134, 1995.

N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride Suppliers

Global Suppliers ( 31)
Supplier Tel Email Country ProdList Advantage
HangZhou YuHao Chemical Technology Co., Ltd. 0571-82693216 info@yuhaochemical.com China 1999 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Jinan Yaoyan Pharmaceutical Co., Ltd. jnyaoyan@163.com China 3057 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com meitaochem@126.com China 19087 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4565 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 5000 58
Supplier Advantage
HangZhou YuHao Chemical Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
Jinan Yaoyan Pharmaceutical Co., Ltd. 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
ShangHai ChuanQian Chemcial Technique Centre 58
Energy Chemical 58
Jinan Jiuli Biotechnology Co. , Ltd. 58

View Latest Price from N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BMS 182874 hydrochloride pictures 2026-07-27 BMS 182874 hydrochloride
1215703-04-0
 $74.00-151.00 97.01% 10g TargetMol Chemicals Inc.

1215703-04-0 (N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride) Related Search:

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BMS182874 N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride BMS-182874 hydrochloride >=98% (HPLC) BMS 182874 hydrochloride, 10 mM in DMSO 5-(dimethylamino)-N-(3,4-dimethylisoxazol-5-yl)naphthalene-1-sulfonamide hydrochloride 1215703-04-0