N-BOC-piperidine-4-carboxylic acid
- CAS No.
- 84358-13-4
- Chemical Name:
- N-BOC-piperidine-4-carboxylic acid
- Synonyms
- 1-(TERT-BUTOXYCARBONYL)PIPERIDINE-4-CARBOXYLIC ACID;BOC-INP-OH;BOC-ISONIPECOTIC ACID;BOC-INP;Boc-DL-Inp-OH;BOC-PIC(4)-OH;AURORA KA-3052;BUTTPARK 99\04-45;RARECHEM AH CK 0061;Bilastine Impurity 74
- CBNumber:
- CB3282481
- Molecular Formula:
- C11H19NO4
- Molecular Weight:
- 229.27
- MDL Number:
- MFCD00076999
- MOL File:
- 84358-13-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Boc-Inp-OH ≥99.0% (HPLC) | 15518 | 5g | $193 |
| 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic Acid >96.0%(GC)(T) | B3241 | 5g | $52 |
| 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic Acid >96.0%(GC)(T) | B3241 | 25g | $150 |
| N-Boc-isonipecotic acid | 261874 | 50g | $319 |
| N-Boc-IsonipecoticAcid | B656728 | 100g | $125 |
| More product size | |||
| Melting point | 148-153 °C |
|---|---|
| Boiling point | 353.2±35.0 °C(Predicted) |
| Density | 1.164±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 4.56±0.20(Predicted) |
| form | Crystalline Powder |
| color | White |
| Water Solubility | Insoluble in water. |
| BRN | 5533442 |
| InChI | InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-8(5-7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14) |
| InChIKey | JWOHBPPVVDQMKB-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(C(O)=O)CC1 |
| CAS DataBase Reference | 84358-13-4(CAS DataBase Reference) |
| FDA UNII | AAZ2CAT47B |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
N-BOC-piperidine-4-carboxylic acid price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 15518 | Boc-Inp-OH ≥99.0% (HPLC) | 84358-13-4 | 5g | $193 | 2025-07-31 | Buy |
| TCI Chemical | B3241 | 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic Acid >96.0%(GC)(T) | 84358-13-4 | 5g | $52 | 2025-07-31 | Buy |
| TCI Chemical | B3241 | 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic Acid >96.0%(GC)(T) | 84358-13-4 | 25g | $150 | 2025-07-31 | Buy |
| Usbiological | 261874 | N-Boc-isonipecotic acid | 84358-13-4 | 50g | $319 | 2021-12-16 | Buy |
| TRC | B656728 | N-Boc-IsonipecoticAcid | 84358-13-4 | 100g | $125 | 2021-12-16 | Buy |
N-BOC-piperidine-4-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder
Uses
It is a pharmaceutical intermediate. he camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
124443-68-1
84358-13-4
General procedure for the synthesis of 1-Boc-4-piperidinecarboxylic acid from methyl 1-Boc-4-piperidinecarboxylate: 4-tert-butyl-4-methylpiperidine-1,4-dicarboxylate (4.84 g, 20 mmol) and LiOH (2.52 g, 60 mmol) were reacted with 4-tert-butyl-4-methylpiperidine-1,4-dicarboxylate (4.84 g, 20 mmol) and LiOH (2.52 g, 60 mmol) in a mixture of THF (90 mL), MeOH (90 mL) and H2O (30 mL) in a solvent, and the reaction was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was adjusted to pH 2 with aqueous 2N HCl. Subsequently, the reaction mixture was extracted with EtOAc (3 × 20 mL). The organic phases were combined, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (4.6 g, 100.0% yield).
References
[1] Patent: WO2012/34526, 2012, A1. Location in patent: Page/Page column 56
[2] Patent: US2013/190307, 2013, A1. Location in patent: Paragraph 0205; 0206
[3] Patent: US2016/102095, 2016, A1. Location in patent: Paragraph 0131
[4] Patent: CN104292233, 2016, B. Location in patent: Paragraph 0047
[5] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00538
N-BOC-piperidine-4-carboxylic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 286 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20183 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13470 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Zjartschem | +86-571 87238903 | jocelynpan@zjarts.com | CHINA | 988 | 58 |
View Lastest Price from N-BOC-piperidine-4-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | N-BOC-piperidine-4-carboxylic acid
84358-13-4
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-01-08 | 1-boc-piperidine-4-carboxylic acid
84358-13-4
|
US $45.00-20.00 / kg | 1kg | 99.60% | 50tons | Wuhan Boyuan Import & Export Co., LTD | |
 |
2023-11-03 | N-BOC-piperidine-4-carboxylic acid
84358-13-4
|
US $10.00 / kg | 1kg | 99% | 100tons | Anhui Zhongda Biotechnology Co., Ltd |
-
- N-BOC-piperidine-4-carboxylic acid
84358-13-4
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 1-boc-piperidine-4-carboxylic acid
84358-13-4
- US $45.00-20.00 / kg
- 99.60%
- Wuhan Boyuan Import & Export Co., LTD
-
- N-BOC-piperidine-4-carboxylic acid
84358-13-4
- US $10.00 / kg
- 99%
- Anhui Zhongda Biotechnology Co., Ltd
84358-13-4(N-BOC-piperidine-4-carboxylic acid)Related Search:
1of4
