ChemicalBook >> CAS DataBase List >>N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1)

N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1)

N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) structure

CAS No.: 936539-80-9

Chemical Name:: N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1)

Synonyms: Betrixaban maleate;Bctriaban;Betrixaban-d;Betrixaban maleate salt;13C6]-Betrixaban maleate salt;N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide maleate;N-(5-chloropyridin-2-yl)-2[4-(N,N-dimethylcarbamimidoyl)-benzoylamino]-5-methoxybenzamide maleate;(E)-N-(5-chloropyridin-2-yl)-2-(4-((2,2-dimethylhydrazono)methyl)benzamido)-5-methoxybenzamide maleate;N-(5-chloropyridin-2-yl)-2-[4-(N,N-dimethylcarbamimidoyl)benzamido]-5-methoxybenzamide maleic acid salt;Inhibitor,PRT 054021,PRT-054021,Betrixaban,antithrombotic effect,Betrixaban maleate,Factor Xa,Fxa,PRT054021,inhibit

CBNumber:: CB33052045

Molecular Formula:: C27H26ClN5O7

Molecular Weight:: 567.98

MDL Number:

MOL File:: 936539-80-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-16 07:06:08

Product description	Number	Pack Size	Price
Betrixaban maleate	FB159537	1mg	$250
Betrixaban maleate	FB159537	2mg	$250
Betrixaban maleate	FB159537	5mg	$299.85
Betrixaban maleate	FB159537	10mg	$449.8
Betrixaban maleate	FB159537	25mg	$749.5
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N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) Properties

storage temp.	Store at -20°C
solubility	DMSO: 100 mg/mL (176.06 mM);Ethanol: Insoluble
form	Solid
color	White to off-white
Water Solubility	Water: 1 mg/mL (1.76 mM)
FDA UNII	28Z3021TMU

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H371
Precautionary statements	P260-P264-P270-P309+P311-P405-P501

N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	FB159537	Betrixaban maleate	936539-80-9	1mg	$250	2026-06-04	Buy
Biosynth	FB159537	Betrixaban maleate	936539-80-9	2mg	$250	2026-06-04	Buy
Biosynth	FB159537	Betrixaban maleate	936539-80-9	5mg	$299.85	2026-06-04	Buy
Biosynth	FB159537	Betrixaban maleate	936539-80-9	10mg	$449.8	2026-06-04	Buy
Biosynth	FB159537	Betrixaban maleate	936539-80-9	25mg	$749.5	2026-06-04	Buy

Product number	Packaging	Price	Buy
FB159537	1mg	$250	Buy
FB159537	2mg	$250	Buy
FB159537	5mg	$299.85	Buy
FB159537	10mg	$449.8	Buy
FB159537	25mg	$749.5	Buy

N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) Chemical Properties,Uses,Production

Uses

Betrixaban (PRT054021) maleate is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC50 of 1.5 nM. Betrixaban maleate shows antithrombotic effect[1][3].

in vivo

Betrixaban (0.5 mg/kg, i.v.; 2.5 mg/kg, p.o.) has oral bioavailability of 51.6% in dog^[1].
Betrixaban (0.75 mg/kg, i.v.; 7.5 mg/kg, p.o.) has oral bioavailability of 58.7% in monkey^[1].
Betrixaban mediated whole-blood INR increase is reversed by r-Antidote. After i.v. infusion for 30 min, the total plasma concentrations of Betrixaban is 0.2±0.01 μM, and the percentages of unbound inhibitor is 40%±7.2%. After administration of r-Antidote, the total plasma concentration increased to 2.0±0.4 μM, and the percentage of unbound inhibitor declined to 0.3%±0.1%^[2].
Betrixaban (3 mg/kg) shows nearly comparable inhibition of thrombus mass to enoxaparin 1.6 mg/kg (76% vs 96% inhibition) in the rabbit abdominal vena cava model of clot accretion on cotton threads^[3].
Betrixaban (19.1 mg/kg) is at least as effective at maintaining patency as enoxaparin 7.6 mg/kg and clopidogrel 3 mg/kg/d (90% vs 70% vs 80% patency, respectively) in the ferric chloride injury model of rodent carotid artery^[3].

References

[1] Zhang P, et al. Discovery of Betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett. 2009 Apr 15;19(8):21. DOI:10.1016/j.bmcl.2009.02.111
[2] Lu G, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013 Apr;19(4):446-51. DOI:10.1038/nm.3102
[3] Chan NC, et al. Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism. Vasc Health Risk Manag. 2015 Jun 26;11:343-51. DOI:10.2147/VHRM.S63060

N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) Suppliers

Global( 99)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	951	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
ANHUI WITOP BIOTECH CO., LTD	+8618071025641	eric@witopchemical.com	China	23504	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9628	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Shenzhen Excellent Biotech Co., Ltd.	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
BOC Sciences	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
changzhou huayang technology co., ltd	58
TargetMol Chemicals Inc.	58

View Lastest Price from N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-08	Betrixaban maleate 936539-80-9	$30.00-100.00		99.86%	10g	TargetMol Chemicals Inc.
2026-06-30	N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) 936539-80-9		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2021-04-16	Betrixaban Maleate 936539-80-9	$1.00	1KG	99%	5000KG	Shenzhen Excellent Biotech Co., Ltd.

Betrixaban maleate
936539-80-9
$30.00-100.00
99.86%
TargetMol Chemicals Inc.

N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1)
936539-80-9
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

Betrixaban Maleate
936539-80-9
$1.00
99%
Shenzhen Excellent Biotech Co., Ltd.

N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) Spectrum

N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1)(936539-80-9)¹HNMR

936539-80-9(N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1))Related Search:

MALEIC ACID MONOSODIUM SALT PHENRAMINE MALEATE Chlorphenamine maleate Cediranib Maleate Betrixaban

2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide

1of2

N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide (2Z)-2-butenedioate (1:1) N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide maleate N-(5-chloropyridin-2-yl)-2-[4-(N,N-dimethylcarbamimidoyl)benzamido]-5-methoxybenzamide maleic acid salt Betrixaban maleate salt Bctriaban N-(5-chloropyridin-2-yl)-2[4-(N,N-dimethylcarbamimidoyl)-benzoylamino]-5-methoxybenzamide maleate 13C6]-Betrixaban maleate salt Benzamide, N-(5-chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-, (2Z)-2-butenedioate (1:1) Inhibitor,PRT 054021,PRT-054021,Betrixaban,antithrombotic effect,Betrixaban maleate,Factor Xa,Fxa,PRT054021,inhibit (E)-N-(5-chloropyridin-2-yl)-2-(4-((2,2-dimethylhydrazono)methyl)benzamido)-5-methoxybenzamide maleate Betrixaban maleate Betrixaban-d 936539-80-9 C23H22ClN5O3C4H4O4 C4H4O4C23H22ClN5O3