Methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate
- CAS No.
- 1401162-80-8
- Chemical Name:
- Methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate
- Synonyms
- Methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate;2-Pyrimidinecarboxylic acid, 4-(4-fluorophenyl)-, methyl ester
- CBNumber:
- CB33066455
- Molecular Formula:
- C12H9FN2O2
- Molecular Weight:
- 232.21
- MDL Number:
- MOL File:
- 1401162-80-8.mol
- MSDS File:
- SDS
Methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA001BYC | Methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate 98% | 1401162-80-8 | 100mg | $67 | 2026-05-28 | Buy |
| aablocks | AA001BYC | Methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate 98% | 1401162-80-8 | 250mg | $110 | 2026-05-28 | Buy |
| aablocks | AA001BYC | Methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate 98% | 1401162-80-8 | 1g | $303 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD240146 | methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate 95% | 1401162-80-8 | 250MG | $170 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD240146 | methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate 95% | 1401162-80-8 | 1G | $465 | 2026-05-27 | Buy |
Methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate Chemical Properties,Uses,Production
Synthesis
85979-59-5
1401162-80-8
General procedure for the synthesis of methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate from 2-chloro-4-(4-fluorophenyl)-pyrimidine: In a 50 mL pressure vial, a methanol (20 mL) solution of 2-chloro-4-(4-fluorophenyl)pyrimidine (1 g, 4.79 mmol) was mixed with PdCl2 (dppf) (0.070 g, 0.096 mmol) and triethylamine (1.336 mL, 9.59 mmol) were mixed. The mixture was pressurized with carbon monoxide (60 psi) and the reaction was stirred at 100 °C for 15 hours. Upon completion of the reaction, the mixture was partitioned between 300 mL of ethyl acetate and 300 mL of water, the organic phase was washed with brine, dried over anhydrous Na2SO4, filtered and concentrated. The residue was separated by chromatography on a Grace Reveleris 40 g silica gel column, using a hexane solution of 0-100% ethyl acetate (flow rate 30 mL/min) as eluent, to afford the title compound, methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate (1.428 g, 6.15 mmol, 64.1% yield), as a brown solid.MS (ESI+ ) m/z 233.0 (M + H)+; 1H NMR (300 MHz, DMSO-d6) δ 9.02 (d, J = 5.4 Hz, 1H), 8.34 (dd, J = 9.1, 5.5 Hz, 2H), 8.29 (d, J = 5.4 Hz, 1H), 7.43 (t, J = 8.9 Hz, 2H), 3.95 (s, 3H).
References
[1] Patent: US2012/245124, 2012, A1. Location in patent: Page/Page column 39-40
Methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 4-(4-fluorophenyl)pyrimidine-2-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Taian Jiaye Biotechnology Co.Ltd | 15318151873;13127280945 | 285424065@qq.com | China | 9961 | 55 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 17754423994 | candy@biochempartner.com | China | 3057 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Zhengzhou Alpha Chemical Co. LTD | 0371-53732842 13383863444 | 3838551451@qq.com | China | 9997 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
