KRIBB11
- CAS No.
- 342639-96-7
- Chemical Name:
- KRIBB11
- Synonyms
- CS-2403;KRIBB11;KRIBB 11;KRIBB-11;KRIBB11, 10 mM in DMSO;N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine;N2-(1H-Indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine;2,6-Pyridinediamine, N2-1H-indazol-5-yl-N6-methyl-3-nitro-;KRIBB11,KRIBB 11,HSP,Apoptosis,Inhibitor,inhibit,Heat shock proteins,KRIBB-11
- CBNumber:
- CB33146317
- Molecular Formula:
- C13H12N6O2
- Molecular Weight:
- 284.27
- MDL Number:
- MFCD30182306
- MOL File:
- 342639-96-7.mol
KRIBB11 price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1412 | KRIBB11 trifluoroacetate salt ≥98% (HPLC) | 342639-96-7 | 5mg | $100 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1412 | KRIBB11 trifluoroacetate salt ≥98% (HPLC) | 342639-96-7 | 25mg | $322 | 2024-03-01 | Buy |
| Cayman Chemical | 9002528 | KRIBB11 ≥95% | 342639-96-7 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 9002528 | KRIBB11 ≥95% | 342639-96-7 | 10mg | $115 | 2024-03-01 | Buy |
| Tocris | 5480 | KRIBB11 ≥99%(HPLC) | 342639-96-7 | 10 | $111 | 2021-12-16 | Buy |
KRIBB11 Chemical Properties,Uses,Production
Uses
KRIBB 11 is a heat shock factor (HSF) inhibitor that induces apoptosis in cancer cells. KRIBB 11 exhibits anticancer properties.
Biological Activity
KRIBB11 is an inhibitor of the transcription factor He at Shock Factor 1 (HSF1) with an IC50 value of 1.2 μM. KRIBB11 blocks induction of HSF1 downstream target proteins such as HSP27 and HSP70 by impairing the recruitment of Positive Transcription Elongation Factor b (P-TEFb) to the HSF1 transcriptional complex, preventing HSF1-mediated gene expression KRIBB11 inhibits tumor growth in vivo and acts synergistically to increase apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin and 17-AAG.', 'KRIBB11 is capable of preventing the proliferation of cancer cells. It has the ability to stimulate apoptosis and can arrest the cell cycle at G2/M phase.
storage
Store at -20°C
KRIBB11 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
