AP39
- CAS No.
- 1429173-57-8
- Chemical Name:
- AP39
- Synonyms
- AP39;AP39 Free base
- CBNumber:
- CB33152549
- Molecular Formula:
- C37H38O2PS3+
- Molecular Weight:
- 641.865
- MDL Number:
- MFCD00947997
- MOL File:
- 1429173-57-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| AP39 ≥95% | 17100 | 1mg | $36 |
| AP39 ≥95% | 17100 | 5mg | $124 |
| AP39 ≥95% | 17100 | 10mg | $229 |
| AP39 ≥95% | 17100 | 25mg | $396 |
| AP39 | EHC17357 | 10mg | $1120.9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H341-H351-H335-H372 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P308+P313-P312-P321-P314-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
AP39 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17100 | AP39 ≥95% | 1429173-57-8 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 17100 | AP39 ≥95% | 1429173-57-8 | 5mg | $124 | 2026-04-30 | Buy |
| Cayman Chemical | 17100 | AP39 ≥95% | 1429173-57-8 | 10mg | $229 | 2026-04-30 | Buy |
| Cayman Chemical | 17100 | AP39 ≥95% | 1429173-57-8 | 25mg | $396 | 2026-04-30 | Buy |
| Biosynth | EHC17357 | AP39 | 1429173-57-8 | 10mg | $1120.9 | 2026-06-04 | Buy |
AP39 Chemical Properties,Uses,Production
Description
AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM. Under oxidative stress conditions induced by glucose oxidase, AP39 has antioxidant and cytoprotective effects. AP39 is effective in vivo, inhibiting voltage-dependent T-type calcium channels and improving hemodynamic parameters in rats.
Uses
AP39 is a compound used to increase the level of hydrogen sulphide within the mitochondria because of the presence of the mitochondria targeting motif (triphenylphosphonium). Also used as a photosensitizer, hydrogen sulfide donor, thioredoxin inhibitor or nitroxide combination use in photodynamic therapy.
References
[1] LENKA TOMASOVA . Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels[J]. Nitric oxide: biology and chemistry, 2015, 46: Pages 131-144. DOI: 10.1016/j.niox.2014.12.012
AP39 Preparation Products And Raw materials
Raw materials
Preparation Products
AP39 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 18621169109 | market03@meryer.com | China | 27963 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17233 | 58 |
| Xi'an Reinforce Biotechnology Co., Ltd. | 15339237155 15339237155 | 2229108118@qq.com | China | 707 | 58 |
