(S)-CR8
- CAS No.
- 1084893-56-0
- Chemical Name:
- (S)-CR8
- Synonyms
- CR8, (S)-Isomer;(S)-CR8, CDK 1, 2, 5, 7 and 9 inhibitor;CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem;(S)-2-((9-Isopropyl-6-((4-(pyridin-2-yl)benzyl)amino)-9H-purin-2-yl)amino)butan-1-ol;1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)-
- CBNumber:
- CB33152923
- Molecular Formula:
- C24H29N7O
- Molecular Weight:
- 431.53
- MDL Number:
- MFCD23160354
- MOL File:
- 1084893-56-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (S)-CR8 | 29985 | 1mg | $44 |
| (S)-CR8 | 29985 | 25mg | $479 |
| (S)-CR8 | 29985 | 5mg | $183 |
| (S)-CR8 | 29985 | 10mg | $278 |
| (S)-CR8 ≥99%(NMR) | AG-MR-C0004-M010 | 10mg | $200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
|
(S)-CR8 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29985 | (S)-CR8 | 1084893-56-0 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 29985 | (S)-CR8 | 1084893-56-0 | 25mg | $479 | 2024-03-01 | Buy |
| Cayman Chemical | 29985 | (S)-CR8 | 1084893-56-0 | 5mg | $183 | 2024-03-01 | Buy |
| Cayman Chemical | 29985 | (S)-CR8 | 1084893-56-0 | 10mg | $278 | 2024-03-01 | Buy |
| Adipogen Life Sciences | AG-MR-C0004-M010 | (S)-CR8 ≥99%(NMR) | 1084893-56-0 | 10mg | $200 | 2021-12-16 | Buy |
(S)-CR8 Chemical Properties,Uses,Production
Description
(S)-CR8 is a second generation derivative of (R)-roscovitine and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 μM, respectively). It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC50s = 0.61 and 0.9 μM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 μM, respectively). It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells.
Uses
(S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selective CDK inhibitor with IC50s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC50 0.40?μM)[1].
Definition
ChEBI: (2S)-2-[[9-propan-2-yl-6-[[4-(2-pyridinyl)phenyl]methylamino]-2-purinyl]amino]-1-butanol is a phenylpyridine.
References
[1] K Bettayeb, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. DOI:10.1038/onc.2008.191
(S)-CR8 Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-CR8 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39032 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 42446 | 60 |
| Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. | 027-65388397 18164111589 | 3321478047@qq.com | China | 2007 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9979 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Suzhou Chenrui Biotechnology Co. LTD | 17625585511 | 1580084073@qq.com | China | 921 | 58 |
