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SHR1258

SHR1258 Structure
SHR1258 structure
CAS No.
1269662-73-8
Chemical Name:
SHR1258
Synonyms
Pyrotinib;SHR-1258;SHR1258;HTI-1001;SHR-1258;SHR1258;Pyrotinib (SHR-1258);Pyrotinib (free base);(R,E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide;2-Propenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methyl-2-pyrrolidinyl]-, (2E)-;(2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methyl-2-pyrrolidinyl]-2-propenamide (ACI)
CBNumber:
CB33159982
Molecular Formula:
C32H31ClN6O3
Molecular Weight:
583.08
MDL Number:
MOL File:
1269662-73-8.mol
MSDS File:
SDS
Last updated:2026-05-28 03:04:34
Request For Quotation

SHR1258 Properties

Boiling point 775.5±60.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 0.172 mg/mL (0.29 mM)
pka 12.30±0.43(Predicted)
form Solid
color Light yellow to yellow
FDA UNII CJN36EQM0H
NCI Drug Dictionary pyrotinib

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P280

SHR1258 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-7940 Pyrotinib 99.89% 1269662-73-8 5mg $222 2026-06-04 Buy
ChemScene CS-7940 Pyrotinib 99.89% 1269662-73-8 10mg $361 2026-06-04 Buy
ChemScene CS-7940 Pyrotinib 99.89% 1269662-73-8 25mg $721 2026-06-04 Buy
ChemScene CS-7940 Pyrotinib 99.89% 1269662-73-8 50mg $1083 2026-06-04 Buy
ChemScene CS-7940 Pyrotinib 99.89% 1269662-73-8 100mg $1625 2026-06-04 Buy
Product number Packaging Price Buy
CS-7940 5mg $222 Buy
CS-7940 10mg $361 Buy
CS-7940 25mg $721 Buy
CS-7940 50mg $1083 Buy
CS-7940 100mg $1625 Buy

SHR1258 Chemical Properties, Uses, Production

Uses

Pyrotinib, is a potent and selective EGFR/HER2 dual inhibitor.

in vivo

Pyrotinib has acceptable bioavailability of 20.6%, 43.5% and 13.5% in nude mice, rats and dogs, respectively. The TGI % (tumor growth inhibition) of Pyrotinib on day 21 is 109%, 157%, 159% at the doses of 5 mg/kg, 10 mg/kg, 20 mg/kg respectively. Pyrotinib in SK-OV-3 ovarian xenograft model shows TGI% on day 21 of 2%, 12%, 83% at the doses of 2.5 mg/kg, 5 mg/kg, 10 mg/kg respectively), which further confirms its robust in vivo antitumor efficacy at 10 mg/kg[1].

IC 50

EGFR: 13 nM (IC50); HER2: 38 nM (IC50)

SHR1258 synthesis

1269662-79-4
852324-28-8
1269662-73-8
Synthesis of SHR1258 from Phosphonic acid, P-[2-[[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]amino]-2-oxoethyl]-, diethyl ester and (2R)-1-Methyl-2-Pyrrolidinecarboxaldehyde

SHR1258 Preparation Products And Raw materials

Raw materials

(2R)-1-Methyl-2-Pyrrolidinecarboxaldehyde Phosphonic acid, P-[2-[[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]amino]-2-oxoethyl]-, diethyl ester 6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile BOC-L-Prolinol L-(+)-Prolinol

Preparation Products

1269662-73-8 (SHR1258) Related Search:

EGFR Protein, HUMAN (621A.A, HEK293, FC) EGFR protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) HER2/CD340 protein, HUMAN (BIOTINYLATED, HEK293, HIS) HER3 Protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) AZD-9291
Amivantamab

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SHR1258 SHR-1258;SHR1258 Pyrotinib (SHR-1258) 2-Propenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methyl-2-pyrrolidinyl]-, (2E)- Pyrotinib (free base) HTI-1001 (R,E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide Pyrotinib SHR-1258 (2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methyl-2-pyrrolidinyl]-2-propenamide (ACI) 1269662-73-8