2,4-Dihydroxypyrimidine-5-carboxylic acid
- CAS No.
- 23945-44-0
- Chemical Name:
- 2,4-Dihydroxypyrimidine-5-carboxylic acid
- Synonyms
- Uracil 5-carboxylate;5-Pyrimidinecarboxylic;URACIL-5-CARBOXYLIC ACID;NSC 79561;ISO-OROTIC ACID;5-carboxyuracil;Uracil Impurity 1;RARECHEM AL BO 2377;Uracil-5-Carboxylic;uracil-5-carboxylicaci
- CBNumber:
- CB3327326
- Molecular Formula:
- C5H4N2O4
- Molecular Weight:
- 156.1
- MDL Number:
- MFCD00006023
- MOL File:
- 23945-44-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,4-Dihydroxypyrimidine-5-carboxylic acid 95% | 126268 | 5g | $59.9 |
| 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid | I1020 | 5G | $38 |
| 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid | I1020 | 25G | $113 |
| 2,4-Dihydroxypyrimidine-5-carboxylic acid | D494868 | 1g | $40 |
| 2,4-Dihydroxypyrimidine-5-carboxylic acid | OR6297 | 1g | $44 |
| More product size | |||
| Melting point | 283 °C (dec.)(lit.) |
|---|---|
| Boiling point | 280.29°C (rough estimate) |
| Density | 1.6814 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in DMSO |
| form | Crystalline Powder |
| pka | 5.08±0.20(Predicted) |
| color | White to slightly yellow |
| Water Solubility | 1.8g/L(20 ºC) |
| InChI | InChI=1S/C5H4N2O4/c8-3-2(4(9)10)1-6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11) |
| InChIKey | ZXYAAVBXHKCJJB-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=C(C(O)=O)C(=O)N1 |
| CAS DataBase Reference | 23945-44-0(CAS DataBase Reference) |
| FDA UNII | G7JYK59EBR |
| EPA Substance Registry System | 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo- (23945-44-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29335990 |
2,4-Dihydroxypyrimidine-5-carboxylic acid price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 126268 | 2,4-Dihydroxypyrimidine-5-carboxylic acid 95% | 23945-44-0 | 5g | $59.9 | 2025-07-31 | Buy |
| TCI Chemical | I1020 | 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid | 23945-44-0 | 5G | $38 | 2025-07-31 | Buy |
| TCI Chemical | I1020 | 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid | 23945-44-0 | 25G | $113 | 2025-07-31 | Buy |
| TRC | D494868 | 2,4-Dihydroxypyrimidine-5-carboxylic acid | 23945-44-0 | 1g | $40 | 2021-12-16 | Buy |
| Apolloscientific | OR6297 | 2,4-Dihydroxypyrimidine-5-carboxylic acid | 23945-44-0 | 1g | $44 | 2021-12-16 | Buy |
2,4-Dihydroxypyrimidine-5-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
white to slightly yellow crystalline powder or
Uses
2,4-Dihydroxypyrimidine-5-carboxylic acid (Uracil-5-carboxylic acid) has been used for the visual sensing of melamine (at parts-per-billion (ppb) level) by a highly sensitive analytical method based on Au nanoparticles.
Definition
ChEBI: Uracil-5-carboxylic acid is a pyrimidinemonocarboxylic acid that is uracil carrying a carboxy group at position 5. It is functionally related to a uracil. It is a conjugate acid of a uracil-5-carboxylate. It is a tautomer of a 2,4-dihydroxypyrimidine-5-carboxylic acid.
General Description
2,4-Dihydroxypyrimidine-5-carboxylic acid (Uracil-5-carboxylic acid) has been obtained from 5-formyluracil by the action of enzyme, thymine 7-hydroxylase. It has been used to synthesize N1-alkylated uracil derivatives.
Synthesis
65-71-4
23945-44-0
The general procedure for synthesizing uracil-5-carboxylic acid from 5-methyluracil was as follows: 100 g of 5-methyluracil and 300 mL of deionized water were added to an autoclave reactor, followed by the addition of 35 mL of a 30% hydrogen peroxide solution. Next, 15 g of 1-hydroxy-1,2,3-benzotriazin-4(3H)-one and 35 g of a pre-prepared catalyst (as described in Example 3) were added. The atmosphere in the autoclave was replaced with oxygen and the reaction system was subsequently heated to 130°C and maintained at this temperature for 3 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and filtered to remove insoluble material. The filtrate was concentrated under reduced pressure and poured into an ice-water mixture for cooling and crystallization, resulting in 150 g of white solid product. The yield of this step was 96.1%, and the purity of the product was 99.3% as analyzed by high performance liquid chromatography (HPLC).
References
[1] Patent: CN108341785, 2018, A. Location in patent: Paragraph 0014-0020
[2] Nucleic Acids Research, 2015, vol. 43, # 20, p. 10026 - 10038
[3] Nucleic Acids Research, 2015, vol. 43, # 20, p. 10026 - 10038
2,4-Dihydroxypyrimidine-5-carboxylic acid Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
View Lastest Price from 2,4-Dihydroxypyrimidine-5-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-10-22 | 2,4-Dihydroxypyrimidine-5-carboxylic acid
23945-44-0
|
US $29.00 / mL | 99.50% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-04 | 2,4-Dihydroxypyrimidine-5-carboxylic acid
23945-44-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
|
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2021-07-13 | 2,4-Dihydroxypyrimidine-5-carboxylic acid
23945-44-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2,4-Dihydroxypyrimidine-5-carboxylic acid
23945-44-0
- US $29.00 / mL
- 99.50%
- TargetMol Chemicals Inc.
-
- 2,4-Dihydroxypyrimidine-5-carboxylic acid
23945-44-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2,4-Dihydroxypyrimidine-5-carboxylic acid
23945-44-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
