CAIX Inhibitor S4
- CAS No.
- 1330061-67-0
- Chemical Name:
- CAIX Inhibitor S4
- Synonyms
- S4 >=98% (HPLC);CAIX Inhibitor S4;CAIX Inhibitor S4, 10 mM in DMSO;4-(3-(3,5-Dimethylphenyl)ureido)phenyl sulfamate;4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamate;Sulfamic acid, 4-[[[(3,5-dimethylphenyl)amino]carbonyl]amino]phenyl ester
- CBNumber:
- CB33309354
- Molecular Formula:
- C15H17N3O4S
- Molecular Weight:
- 335.38
- MDL Number:
- MFCD30182321
- MOL File:
- 1330061-67-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| S4 ≥98% (HPLC) | SML2031 | 5MG | $98.4 |
| S4 ≥98% (HPLC) | SML2031 | 25MG | $397 |
| CAIX Inhibitor S4 ≥98% | 31119 | 5mg | $90 |
| CAIX Inhibitor S4 ≥98% | 31119 | 10mg | $158 |
| CAIX Inhibitor S4 ≥98% | 31119 | 25mg | $370 |
| Density | 1.429±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO: 30 mg/ml |
| pka | 8.63±0.70(Predicted) |
| form | A solid |
| color | White to off-white |
| InChI | InChI=1S/C15H17N3O4S/c1-10-7-11(2)9-13(8-10)18-15(19)17-12-3-5-14(6-4-12)22-23(16,20)21/h3-9H,1-2H3,(H2,16,20,21)(H2,17,18,19) |
| InChIKey | HGVHSNXRZYOTPD-UHFFFAOYSA-N |
| SMILES | S(N)(OC1=CC=C(NC(NC2=CC(C)=CC(C)=C2)=O)C=C1)(=O)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
CAIX Inhibitor S4 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2031 | S4 ≥98% (HPLC) | 1330061-67-0 | 5MG | $98.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2031 | S4 ≥98% (HPLC) | 1330061-67-0 | 25MG | $397 | 2026-04-30 | Buy |
| Cayman Chemical | 31119 | CAIX Inhibitor S4 ≥98% | 1330061-67-0 | 5mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 31119 | CAIX Inhibitor S4 ≥98% | 1330061-67-0 | 10mg | $158 | 2026-04-30 | Buy |
| Cayman Chemical | 31119 | CAIX Inhibitor S4 ≥98% | 1330061-67-0 | 25mg | $370 | 2026-04-30 | Buy |
CAIX Inhibitor S4 Chemical Properties,Uses,Production
Uses
S4 is a sulfamate carbonic anhydrase IX (CAIX) inhibitor in colorectal carcinoma cell lines.
Biological Activity
S4 is a potent and selective inhibitor against sulfamate carbonic anhydrase (CA) subtypes CAIX & CAXII (Ki = 2, 7, 546, 5600 nM against human CA XII, IX, II, and I, respectively). S4 selectively inhibits migration upon anoxia/hypoxia-induced CAIX expression in cancer cultures (% inhibition/conc./cell line = 54%/100 μM/WRO, 65%/33 μM/MDA-MB-231), while exhibiting no inhibitory effects under normoxia or among non-CAIX-expressing cells (HCT116 & RT112). Daily intraperitoneal injection (10 mg/kg) is reported to reduce the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors in vivo.
in vivo
CAIX Inhibitor S4 (10 mg/kg; i.p. for 14 days) inhibits metastatic tumor burden in MDA-MB-231 model while having no effect on primary tumor growth or mouse condition[1].
| Animal Model: | Female nu/nu CBA mice (10-12 weeks) were injected with eGFP-MDA-MB-231 cells[1] |
| Dosage: | 10 mg/kg |
| Administration: | I.p. daily on a “5 days on, 2 days off” dosing regimen for 14 days |
| Result: | Significantly reduced the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors. The average body weights between vehicle and S4 treated mice were similar throughout the experiments. |
IC 50
CA Ⅸ
storage
Store at +4°C
CAIX Inhibitor S4 Preparation Products And Raw materials
Raw materials
Preparation Products
CAIX Inhibitor S4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Wuhan Quanjinci New Material Co.,Ltd. | +86-15271838296; +8615271838296 | kyra@quanjinci.com | China | 1512 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
View Lastest Price from CAIX Inhibitor S4 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | CAIX Inhibitor S4
1330061-67-0
|
US $34.00-97.00 / mg | 99.07% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-09-29 | S4
1330061-67-0
|
US $1.00 / g | 1g | 99 | 20tons | Shanghai Longyu Biotechnology Co., Ltd. | |
 |
2024-03-31 | CAIX Inhibitor S4
1330061-67-0
|
US $30.00-10.00 / BOX | 10BOX | 99 | 20TONS | Shanghai Chinqesen Biotechnology Co., Ltd. |
-
- CAIX Inhibitor S4
1330061-67-0
- US $34.00-97.00 / mg
- 99.07%
- TargetMol Chemicals Inc.
-
- S4
1330061-67-0
- US $1.00 / g
- 99
- Shanghai Longyu Biotechnology Co., Ltd.
-
- CAIX Inhibitor S4
1330061-67-0
- US $30.00-10.00 / BOX
- 99
- Shanghai Chinqesen Biotechnology Co., Ltd.
