CWP232228
- CAS No.
- 1144044-02-9
- Chemical Name:
- CWP232228
- Synonyms
- CWP232228;CWP232228?sodium;CWP232228 disodium;Beta catenin,Wnt,Breast,β-catenin,Inhibitor,CWP232228,CWP 232228,cells,signaling,stem,Cancer,inhibit,liver,CWP-232228;Sodium 4-(((6S,9aS)-2-allyl-1-(benzylcarbamoyl)-8-((2-methyl-2H-indazol-7-yl)methyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl phosphate
- CBNumber:
- CB33354107
- Molecular Formula:
- C33H37N7NaO7P
- Molecular Weight:
- 697.66
- MDL Number:
- MFCD30533611
- MOL File:
- 1144044-02-9.mol
| Product description | Number | Pack Size | Price |
| CWP232228 98.31% | CS-0014678 | 5mg | $650 |
| CWP232228 98.31% | CS-0014678 | 10mg | $980 |
CWP232228 Chemical Properties,Uses,Production
Uses
CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs)[1].
in vivo
CWP232228 (100 mg/kg, administered i.p.; daily; 21days for mice bearing 4T1 cell tumors; 60 days for mice bearing MDA-MB-435 cell tumors) results in a significant reduction in tumor volume[1].
| Animal Model: | 7-week-old female Balb/c and NOD/SCID mice bearing 4T1 or MDA-MB-435 cell tumors[1] |
| Dosage: | 100 mg/kg |
| Administration: | Administered i.p.; daily; 21days for mice bearing 4T1 cell tumors, 60 days for mice bearing MDA-MB-435 cell tumors |
| Result: | Treatment resulted in a significant reduction in tumor volume. |
References
[1] Jang GB, et al. Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells. Cancer Res. 2015 Apr 15;75(8):1691-702. DOI:10.1158/0008-5472.CAN-14-2041
[2] Kim JY, et al. Oncotarget. 2016 Apr 12;7(15):20395-409. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment. DOI:10.18632/oncotarget.7954
CWP232228 Preparation Products And Raw materials
Raw materials
Preparation Products
CWP232228 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shanghai fuxiang biotechnology co., ltd | 13611719524 | 2674347328@qq.com | China | 58 | 58 |
| Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6003 | 61 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4764 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Yu Ben Biotechnology Co., Ltd. | 15502154572 | yuben012@sina.com | China | 490 | 58 |
