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ChemicalBook >> CAS DataBase List >>1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene Structure
1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene structure
CAS No.
6683-48-3
Chemical Name:
1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene
Synonyms
6-Pentamethyl-1;Bexarotene Impurity 14;2-methyl-5,6,7,8-tetrahydro-;1,1,4,4,6-Pentamethyltetralin;1,1,4,4,6-Pentamethyl-1,2,3,4-;1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaph;1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydrophthalene;1,1,4,4,6-Pentamethyl-1,2,3,4-etrahydronaphthalene;1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphtalene;1,1,4,4,6-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE
CBNumber:
CB3335653
Molecular Formula:
C15H22
Molecular Weight:
202.34
MDL Number:
MFCD00833394
MOL File:
6683-48-3.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:54
Request For Quotation

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene Properties

Melting point 31
Boiling point 60-64°C 0,2mm
Density 0.882±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Sparingly), Methanol (Slightly)
form Solid
color Colourless to Pale Yellow Oil
InChI InChI=1S/C15H22/c1-11-6-7-12-13(10-11)15(4,5)9-8-14(12,2)3/h6-7,10H,8-9H2,1-5H3
InChIKey AISXBZVAYNUAKB-UHFFFAOYSA-N
SMILES C1(C)(C)C2=C(C=C(C)C=C2)C(C)(C)CC1
FDA UNII KT2SN6375F

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Hazard Codes  Xi
Risk Statements  20/21/22
Safety Statements  26-36/37/39
HazardClass  IRRITANT
HS Code  2917399590
NFPA 704
1
2 0

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific B665 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethyl-naphthalene 6683-48-3 1g $14 2021-12-16 Buy
Matrix Scientific 024956 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphthalene 95% 6683-48-3 5g $34 2021-12-16 Buy
Matrix Scientific 024956 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphthalene 95% 6683-48-3 25g $96 2021-12-16 Buy
AK Scientific B665 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethyl-naphthalene 6683-48-3 25g $114 2021-12-16 Buy
ChemScene CS-B0383 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene ≥99.0% 6683-48-3 100g $122 2021-12-16 Buy
Product number Packaging Price Buy
B665 1g $14 Buy
024956 5g $34 Buy
024956 25g $96 Buy
B665 25g $114 Buy
CS-B0383 100g $122 Buy

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Targretin analog, has been shown to induce apoptosis in certain leukemia cell lines.

Synthesis

2,5-DICHLORO-2,5-DIMETHYLHEXANE

6223-78-5

Toluene

108-88-3

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene

6683-48-3

1. In a dry reaction flask, dissolve 2,5-dichloro-2,5-dimethylhexane (10 g, 54.7 mmol) in toluene (270 mL) and stir until completely dissolved. 2. slowly add anhydrous aluminum trichloride (5.47 g, 41 mmol) to the above solution in batches over 15 minutes, taking care to control the addition rate to avoid intense exotherm. 3. After the addition, the reaction was continued with stirring for 10 minutes, and the progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent: hexane) to confirm the completion of the reaction. 4. Under cooling in an ice bath, slowly add water dropwise (~10 min) to quench the unreacted aluminum trichloride, taking care to control the rate of dropwise acceleration to avoid intense exotherm. 5. The reaction mixture is extracted with toluene (250 mL) and the organic layer is separated. 6. The organic layer was filtered through a silica gel pad (40 g) and eluted with toluene to remove possible polar impurities. 7. The organic phases were combined and concentrated to dryness under reduced pressure to afford the crude product 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene (11 g, 97% yield). 8. The product was characterized by nuclear magnetic resonance hydrogen spectroscopy (1H NMR): δ 1.29 (s, 6H), 1.28 (s, 6H), 1.69 (s, 4H), 2.32 (s, 3H), 7.22 (d, 1H), 7.12 (s, 1H), 6.97 (dd, 1H).

References

[1] Journal of Organic Chemistry, 1991, vol. 56, # 15, p. 4706 - 4713
[2] Journal of Organic Chemistry, 2001, vol. 66, # 17, p. 5772 - 5782
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 23, p. 3467 - 3470
[4] Patent: US2004/10033, 2004, A1. Location in patent: Page/Page column 11
[5] Patent: WO2003/106446, 2003, A1. Location in patent: Page 19-20

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene synthesis

110-03-2
6683-48-3
Synthesis of 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene from 2,5-Dimethyl-2,5-hexanediol

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene Preparation Products And Raw materials

Raw materials

2(1H)-Naphthalenone, 3,4-dihydro-1,1,4,4,7-pentamethyl- 167958-79-4 1,1,4,4,7-Pentamethyl-1,2,3,4-tetrahydronaphthalen-2-ol 2,5-Dimethyl-2,5-hexanediol 2,2,5,5-TETRAMETHYLTETRAHYDROFURAN-3-ONE
2,5-DICHLORO-2,5-DIMETHYLHEXANE 2-[2-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-6-methylpyran-4-ylidene]propanedinitrile Toluene

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Preparation Products

Bexarotene 6-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALENE-2-CARBONYL)-NICOTINIC ACID METHYL ESTER

1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene Suppliers

Global( 147)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 9029 58
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Changzhou Carman Chemical Co., Ltd. 		15061933924 CHINA 514 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4017 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Supplier Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Shanghai Time Chemicals CO., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Changzhou Carman Chemical Co., Ltd. 		58
SIMAGCHEM CORP 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Hefei Hirisun Pharmatech Co., Ltd 		58

View Lastest Price from 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,1,4,4,6-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE pictures 2025-06-13 1,1,4,4,6-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE
6683-48-3
 US $2.20-8.80 / kg 1kg 99%min 1000kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene pictures 2019-07-06 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3
 US $1.00 / kg 1kg 99% as request Career Henan Chemical Co

6683-48-3(1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene)Related Search:

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TTNPB (Arotinoid Acid) 6-ACETYL-1,1,2,4,4,7-HEXAMETHYLTETRALIN 2-BROMO-1-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)ETHAN-1-ONE Hexamethylenetetramine linarotene
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1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaph Bexarotene Impurity 14 1,2,3,4-Tetrahydro-1,1,4,4,6-pentamethylnaphtalene 1,2,3,4-TETRAHYDRO-1,1,4,4,6-PENTAMETHYLNAPHTHALENE 1,2,3,4-TETRAHYDRO-1,1,4,4,6-PENTAMETHYLNAPHTHYLENE 1,1,4,4,6-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE 1,1,4,4,6-Pentamethyltetralin 1,1,4,4,6-Pentamethyl-1,2,3,4-etrahydronaphthalene 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene, tech 1,1,4,4,6-Pentamethyl-1,2,3,4- 1,2,3,4-TETRAHYDRO-1,1,4,4,6-PENTAMETHYLNAPHTALENE: TECH. Naphthalene, 1,2,3,4-tetrahydro-1,1,4,4,6-pentaMethyl- 2-Methyl-5,6,7,8-tetrahydro- 5,5,8,8-tetraMethyl naphthalene 2-methyl-5,6,7,8-tetrahydro- 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydrophthalene 1,2,3,4-Tetrahydro-1,1,2,2,6-pentamethylnaphthalene 6-Pentamethyl-1 6683-48-3 C15H22 Fused Ring Systems Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Retinoids