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4beta-Hydroxywithanolide E

4beta-Hydroxywithanolide E structure

CAS No.: 54334-04-2

Chemical Name:: 4beta-Hydroxywithanolide E

Synonyms: 4β-HydroxywithanolideE;4β-Hydroxywithanolide E;4beta-Hydroxywithanolide E;5β,6β-epoxy-4β,14,17α,20,22R-pentahydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, ?-lactone;Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, δ-lactone, (4β,5β,6β,17α,22R)-

CBNumber:: CB33372402

Molecular Formula:: C28H38O8

Molecular Weight:: 502.6

MDL Number:

MOL File:: 54334-04-2.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

Product description	Number	Pack Size	Price
4β-Hydroxywithanolide E ≥95%	27245	1mg	$840
4β-Hydroxywithanolide E	27245	1mg	$763
4BETA-HYDROXYWITHANOLIDE E 95.00%	INB0001928	5MG	$505.84

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4beta-Hydroxywithanolide E Properties

storage temp.	Store at -20°C
solubility	Chloroform: soluble; Ethanol: soluble; Methanol: soluble
form	A crystalline solid

4beta-Hydroxywithanolide E price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	27245	4β-Hydroxywithanolide E ≥95%	54334-04-2	1mg	$840	2026-04-30	Buy
Cayman Chemical	27245	4β-Hydroxywithanolide E	54334-04-2	1mg	$763	2024-03-01	Buy
American Custom Chemicals Corporation	INB0001928	4BETA-HYDROXYWITHANOLIDE E 95.00%	54334-04-2	5MG	$505.84	2021-12-16	Buy

Product number	Packaging	Price	Buy
27245	1mg	$840	Buy
27245	1mg	$763	Buy
INB0001928	5MG	$505.84	Buy

4beta-Hydroxywithanolide E Chemical Properties,Uses,Production

Description

4β-Hydroxywithanolide E is a withanolide steroidal lactone that has been found in P. peruviana and has anti-inflammatory and anticancer activities.^1,2,3 It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells and TNF-α-induced NF-κB activity in HEK293 cells (IC₅₀s = 0.32 and 0.04 μM, respectively).¹ 4β-Hydroxywithanolide E (5 μM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 levels and Akt and STAT1 phosphorylation in RAW 264.7 cells.² It inhibits Wnt signaling in HCT116 and SW480 colorectal cancer cells (IC₅₀s = 1.85 and 2.67 μM, respectively).³ 4β-Hydroxywithanolide E inhibits the proliferation of HCT116, SW480, HT-29, and LoVo cells (IC₅₀s = 0.24-0.51 μM). It halts the cell cycle at the G₀/G₁ phase in HCT116 and HT-29 cells and induces apoptosis in HCT116 and SW480 cells in a concentration-dependent manner. 4β-Hydroxywithanolide E (10 mg/kg per day for 14 days) reduces tumor growth in an HCT116 mouse xenograft model.

Uses

4β-Hydroxywithanolide E, isolated from Physalis peruviana L., inhibits adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion. 4β-Hydroxywithanolide E is an adipogenesis inhibitor and inhibits PPARγ, C/EBPα, and the adipocyte-specific molecule aP2 mRNA expression[1].

Definition

ChEBI: 4beta-Hydroxywithanolide E is a withanolide.

References

1. Sang-Ngern, M., Youn, U.J., Park, E.J., et al. Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity Bioorg. Med. Chem. Lett. 26(12),2755-2759(2016).
2. Park, E.J., Sang-Ngern, M., Chang, L.C., et al. Physalactone and 4β-hydroxywithanolide E isolated from Physalis peruviana inhibit LPS-induced expression of COX-2 and iNOS accompanied by abatement of Akt and STAT1 J. Nat. Prod. 82(3),492-499(2019).
3. Ye, Z.N., Yuan, F., Liu, J.Q., et al. Physalis peruviana-derived 4β-hydroxywithanolide E, a novel antagonist of Wnt signaling, inhibits colorectal cancer in vitro and in vivo Molecules 24(6),E1146(2019).

4beta-Hydroxywithanolide E Preparation Products And Raw materials

Raw materials

Preparation Products

4beta-Hydroxywithanolide E Suppliers

Global( 28)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30227	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39040	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
BioBioPha Co., Ltd.	0871-65217109 13211707573;	y.liu@mail.biobiopha.com	China	5645	65
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7777	56
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632	sales@reading-chemicals.com	China	15178	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9803	58
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	89689	60

Supplier	Advantage
Career Henan Chemica Co	58
Labnetwork lnc.	58
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
BioBioPha Co., Ltd.	65
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60

54334-04-2(4beta-Hydroxywithanolide E)Related Search:

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4beta-Hydroxywithanolide E 4β-Hydroxywithanolide E Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, δ-lactone, (4β,5β,6β,17α,22R)- 4β-HydroxywithanolideE 5β,6β-epoxy-4β,14,17α,20,22R-pentahydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, ?-lactone 54334-04-2