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GNE 220

GNE 220 Structure
GNE 220 structure
CAS No.
1199590-75-4
Chemical Name:
GNE 220
Synonyms
GNE 220;5H-Pyrido[3',2':4,5]pyrrolo[3,2-d]pyrimidine, 4-methyl-8-[4-(4-methyl-1-piperazinyl)phenyl]-2-(1-methyl-1H-pyrazol-4-yl)-;6-Methyl-12-[4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrazol-4-yl)-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12 -hexaene
CBNumber:
CB33386483
Molecular Formula:
C25H26N8
Molecular Weight:
438.52754
MDL Number:
MFCD31619318
MOL File:
1199590-75-4.mol
Last updated:2025-07-23 21:37:54
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GNE 220 Properties

Density 1.38±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 11.21±0.50(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2934999090

GNE 220 Chemical Properties,Uses,Production

Uses

GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM.

IC 50

MAP4K4: 7 nM (IC50); MAP4K5: 9 nM (IC50); MAP4K6: 1.1 μM (IC50)

References

[1] Vitorino P, et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature. 2015 Mar 26;519(7544):425-30. DOI:10.1038/nature14323

GNE 220 Preparation Products And Raw materials

Raw materials

Preparation Products

GNE 220 Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32371 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38825 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19938 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 1000 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24981 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 6051 58
Guangzhou Leyan Biotechnology Co., Ltd. 15096011602 CHINA 0 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Fan De(Beijing) Biotechnology Co., Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
Biosynth Biological Technology (Suzhou) Co Ltd 58
Guangzhou Leyan Biotechnology Co., Ltd. 58

View Lastest Price from GNE 220 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GNE 220 pictures 2025-07-23 GNE 220
1199590-75-4
 US $3400.00-1970.00 / mg 10g TargetMol Chemicals Inc.
GNE 220 pictures 2024-10-28 GNE 220
1199590-75-4
 US $3400.00-1970.00 / mg 10g TargetMol Chemicals Inc.
  • GNE 220 pictures
  • GNE 220
    1199590-75-4
  • US $3400.00-1970.00 / mg
  • TargetMol Chemicals Inc.
  • GNE 220 pictures
  • GNE 220
    1199590-75-4
  • US $3400.00-1970.00 / mg
  • TargetMol Chemicals Inc.
GNE 220 5H-Pyrido[3',2':4,5]pyrrolo[3,2-d]pyrimidine, 4-methyl-8-[4-(4-methyl-1-piperazinyl)phenyl]-2-(1-methyl-1H-pyrazol-4-yl)- 6-Methyl-12-[4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrazol-4-yl)-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12 -hexaene 1199590-75-4 C25H26N8