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ChemicalBook >> CAS DataBase List >>4-(BROMOMETHYL)-2-FLUOROBENZONITRILE

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Structure
4-(BROMOMETHYL)-2-FLUOROBENZONITRILE structure
CAS No.
222978-03-2
Chemical Name:
4-(BROMOMETHYL)-2-FLUOROBENZONITRILE
Synonyms
4-CYANO-3-FLUOROBENZYL BROMIDE;4-Cyano-3-fluorobenzylbromide98%;4-Cyano-3-fluorobenzyl bromide 98%;4-(BROMOMETHYL)-2-FLUOROBENZONITRILE;Benzonitrile, 4-(bromomethyl)-2-fluoro-;4-(Bromomethyl)-2-fluorobenzonitrile 98%;4-Cyano-3-fluorobenzyl bromide, alpha-Bromo-2-fluoro-p-tolunitrile
CBNumber:
CB3339303
Molecular Formula:
C8H5BrFN
Molecular Weight:
214.03
MDL Number:
MFCD03094323
MOL File:
222978-03-2.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:47
Product description Number Pack Size Price
4-(Bromomethyl)-2-fluorobenzonitrile B697158 1g $50
4-(Bromomethyl)-2-fluorobenzonitrile B697158 10g $160
4-Cyano-3-fluorobenzyl bromide FC37300 500mg $80
4-(Bromomethyl)-2-fluorobenzonitrile 98% PC5928 5g $124
4-Cyano-3-fluorobenzyl bromide FC37300 1g $125
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4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Properties

Melting point 44-45 °C
Boiling point 275.6±30.0 °C(Predicted)
Density 1.59±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Methanol (Slightly)
form Solid
color Off-White
Sensitive Lachrymatory

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H314-H334
Precautionary statements  P271-P260-P280
Hazard Codes  C,Xn
Risk Statements  20/21/22
Safety Statements  36/37
Hazard Note  Corrosive/Lachrymatory
HS Code  2926907090

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B697158 4-(Bromomethyl)-2-fluorobenzonitrile 222978-03-2 1g $50 2021-12-16 Buy
TRC B697158 4-(Bromomethyl)-2-fluorobenzonitrile 222978-03-2 10g $160 2021-12-16 Buy
Biosynth Carbosynth FC37300 4-Cyano-3-fluorobenzyl bromide 222978-03-2 500mg $80 2021-12-16 Buy
Apolloscientific PC5928 4-(Bromomethyl)-2-fluorobenzonitrile 98% 222978-03-2 5g $124 2021-12-16 Buy
Biosynth Carbosynth FC37300 4-Cyano-3-fluorobenzyl bromide 222978-03-2 1g $125 2021-12-16 Buy
Product number Packaging Price Buy
B697158 1g $50 Buy
B697158 10g $160 Buy
FC37300 500mg $80 Buy
PC5928 5g $124 Buy
FC37300 1g $125 Buy

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Chemical Properties,Uses,Production

Uses

4-(Bromomethyl)-2-fluorobenzonitrile is a useful building block for the preparation and optimization of the highly selective GLUT1 inhibitor, BAY-876.

Synthesis

2-Fluoro-4-methylbenzonitrile

85070-67-3

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE

222978-03-2

2-Fluoro-4-methylbenzonitrile (10 g, 74.07 mmol) was used as a raw material, which was dissolved in 200 mL of chloroform, 1 g of benzoyl peroxide (BPO) was added, and stirred until completely dissolved. Subsequently, N-bromosuccinimide (NBS, 19.77 g, 11.11 mmol) was added in batches and the reaction mixture was refluxed for 12 hours. After completion of the reaction, it was cooled to room temperature and washed three times with saturated aqueous sodium bicarbonate solution, then three times with appropriate amount of water and finally three times with saturated brine. The solvent was removed by evaporation under reduced pressure and purified by column chromatography to give the light yellow liquid product 4-cyano-3-fluorobenzyl bromide (14.00 g) in 88.79% yield.

References

[1] Patent: CN106810552, 2017, A. Location in patent: Paragraph 0068; 0070; 0071
[2] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1325 - 1344
[3] Organic and Biomolecular Chemistry, 2004, vol. 2, # 9, p. 1339 - 1352
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 20, p. 2925 - 2930
[5] Journal of the American Chemical Society, 2001, vol. 123, # 9, p. 2107 - 2108

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE synthesis

85070-67-3
222978-03-2
Synthesis of 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE from 2-Fluoro-4-methylbenzonitrile

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Preparation Products And Raw materials

Raw materials

4-Cyano-3-fluorobenzoyl chloride PROPANENTRILE,2,2'-[(1E)-1,2-DIAZENEDIYL]BIS(2-METHYLPROPIONITRILE) 4-Bromo-3-fluorobenzoic acid 2-FLUORO-4-(HYDROXYMETHYL)BENZONITRILE 1,1'-Azobis(cyanocyclohexane)
(4-BROMO-3-FLUOROPHENYL)METHANOL Methyl 4-cyano-3-fluorobenzoate 4-Cyano-3-fluorobenzoic acid 2-Fluoro-4-methylbenzonitrile 4-Bromo-3-fluorotoluene
N-Bromosuccinimide Dimethyl sulfide

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Preparation Products

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Suppliers

Global( 101)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20128 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 9948 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30229 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Changzhou Anxuan Chemical Co., Ltd 		+86-0519-89882563 +86-18961279162 andy@anxuanchem.com China 4327 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 24705 58
Aromsyn Co., Ltd. 		+86-0571-85585865 +8613336024896 CB@aromsyn.com China 19183 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Fuxin Pharmaceutical 		58
Career Henan Chemica Co 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Changzhou Anxuan Chemical Co., Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Aromsyn Co., Ltd. 		58

View Lastest Price from 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(BROMOMETHYL)-2-FLUOROBENZONITRILE pictures 2025-09-25 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE
222978-03-2
 US $101.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Spectrum

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE(222978-03-2)1HNMR

222978-03-2(4-(BROMOMETHYL)-2-FLUOROBENZONITRILE)Related Search:

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4-(BROMOMETHYL)-3-FLUOROBENZONITRILE 4-Cyanobenzyl bromide 2-Fluoro-4-methylbenzonitrile

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4-Cyano-3-fluorobenzyl bromide 98% 4-Cyano-3-fluorobenzylbromide98% 4-CYANO-3-FLUOROBENZYL BROMIDE 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE 4-(Bromomethyl)-2-fluorobenzonitrile 98% 4-Cyano-3-fluorobenzyl bromide, alpha-Bromo-2-fluoro-p-tolunitrile Benzonitrile, 4-(bromomethyl)-2-fluoro- 222978-03-2 Fluorine series