5-Chloro-2-methoxyphenylboronic acid
- CAS No.
- 89694-48-4
- Chemical Name:
- 5-Chloro-2-methoxyphenylboronic acid
- Synonyms
- AKOS BRN-0073;CHEMBRDG-BB 3200964;RARECHEM AH PB 0263;oro-2-methoxyphenyL;5-Chloro-2-methoxyph;5-Chloro-2-Methoxyphenylboroni;4-Chloroanisole-2-boronic acid;5-Chloro-2-methoxyphenylboronic;5-chloro-2-methoxyphenylboric acid;5-Chloro-2-methoxyphenyboronic acid
- CBNumber:
- CB3344109
- Molecular Formula:
- C7H8BClO3
- Molecular Weight:
- 186.4
- MDL Number:
- MFCD01318966
- MOL File:
- 89694-48-4.mol
| Product description | Number | Pack Size | Price |
| 5-Chloro-2-methoxyphenylboronic acid | 512249 | 5g | $50.9 |
| 5-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride) | C2292 | 5g | $77 |
| 5-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride) | C2292 | 25g | $229 |
| 5-Chloro-2-methoxyphenylboronic acid 99.12% | CS-D1034 | 25g | $46 |
| 5-Chloro-2-methoxyphenylboronic acid | FC149774 | 25g | $50 |
| More product size | |||
| Melting point | 134-141 °C(lit.) |
|---|---|
| Boiling point | 360.2±52.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| pka | 7.58±0.58(Predicted) |
| color | White |
| InChI | InChI=1S/C7H8BClO3/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4,10-11H,1H3 |
| InChIKey | FMBVAOHFMSQDGT-UHFFFAOYSA-N |
| SMILES | B(C1=CC(Cl)=CC=C1OC)(O)O |
| CAS DataBase Reference | 89694-48-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
5-Chloro-2-methoxyphenylboronic acid price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 512249 | 5-Chloro-2-methoxyphenylboronic acid | 89694-48-4 | 5g | $50.9 | 2023-06-20 | Buy |
| TCI Chemical | C2292 | 5-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride) | 89694-48-4 | 5g | $77 | 2025-07-31 | Buy |
| TCI Chemical | C2292 | 5-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride) | 89694-48-4 | 25g | $229 | 2025-07-31 | Buy |
| ChemScene | CS-D1034 | 5-Chloro-2-methoxyphenylboronic acid 99.12% | 89694-48-4 | 25g | $46 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC149774 | 5-Chloro-2-methoxyphenylboronic acid | 89694-48-4 | 25g | $50 | 2021-12-16 | Buy |
5-Chloro-2-methoxyphenylboronic acid Chemical Properties,Uses,Production
Chemical Properties
White to off-white powder
Uses
Reactant for:• ;Boron-Heck arylation1• ;Suzuki-Miyaura reaction2
Uses
suzuki reaction
Synthesis
121-43-7
60633-25-2
89694-48-4
The general procedure for the synthesis of 5-chloro-2-methoxyphenylboronic acid from trimethyl borate and 2-bromo-4-chloroanisole is as follows: 5-chloro-2-methoxyphenylboronic acid (Structure 37 of Scheme XI, wherein R1 = H, R2 = Cl) was prepared in a similar manner to 5-fluoro-2-methoxyphenylboronic acid (Example 107). This was done as follows: in a dry reaction flask, 2-bromo-4-chloroanisole (2.00 g, 9.0 mmol, 1.0 eq.) was added, cooled to -78°C under anhydrous and oxygen-free conditions, n-butyllithium (2.5 M hexane solution, 3.62 mL, 9.0 mmol, 1.0 eq.) was slowly added and the reaction was stirred for 30 minutes. Subsequently, trimethyl borate (3.0 mL, 26 mmol, 2.9 eq.) was added dropwise and the reaction was continued at -78°C for 2 hours. After completion of the reaction, it was slowly warmed to room temperature, the reaction was quenched with water, extracted with ethyl acetate, the organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 1.30 g (77% yield) of crude 5-chloro-2-methoxyphenylboronic acid as a white semi-solid. The compound did not require further purification and could be used directly in the next step of the reaction. Next, the crude 5-chloro-2-methoxyphenylboronic acid was used for the synthesis of methyl (5'-chloro-2'-methoxy-4-nitro-2-biphenylyl) carboxylate (Structure 39 of Scheme XI, where R1 = H, R2 = Cl).
References
[1] Patent: US5688808, 1997, A
[2] Patent: US5688810, 1997, A
[3] Patent: US5693646, 1997, A
[4] Patent: US5693647, 1997, A
[5] Patent: US5696127, 1997, A
5-Chloro-2-methoxyphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Maison Chemical Co.,Ltd. | +8615511852758 | sales@maisonchem.com.cn | China | 484 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20128 | 58 |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13799 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Beijing Green Guardee Technology Co., Ltd | 86-010-69706062 | sales2@greenguardee.com | CHINA | 650 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
View Lastest Price from 5-Chloro-2-methoxyphenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-09-25 | 5-Chloro-2-methoxyphenylboronic acid
89694-48-4
|
US $34.00-1.20 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-05-04 | 5-Chloro-2-methoxyphenylboronic acid
89694-48-4
|
US $48.00-40.00 / Kg | 1KG | 99% | 200tons | Guangzhou Sunton Biotechnology Co., Ltd. | |
 |
2023-03-13 | 5-Chloro-2-methoxyphenylboronic acid
89694-48-4
|
US $0.00-0.00 / kg | 1kg | 98%Min | 1000kg | LY Global chemicals co.,ltd . |
-
- 5-Chloro-2-methoxyphenylboronic acid
89694-48-4
- US $34.00-1.20 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 5-Chloro-2-methoxyphenylboronic acid
89694-48-4
- US $48.00-40.00 / Kg
- 99%
- Guangzhou Sunton Biotechnology Co., Ltd.
-
- 5-Chloro-2-methoxyphenylboronic acid
89694-48-4
- US $0.00-0.00 / kg
- 98%Min
- LY Global chemicals co.,ltd .
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