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TBTU
- CAS No.
- 125700-67-6
- Chemical Name:
- TBTU
- Synonyms
- TBTU;2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE;TBPIPU;TBTU N;TBTU, 98%;TBTU 99.5%;KNORR REAGENT;TBTU extrapure;TBTU [ 125700-67-6;TBTU (Knorr reagent)
- CBNumber:
- CB3357547
- Molecular Formula:
- C11H16BF4N5O
- Molecular Weight:
- 321.09
- MDL Number:
- MFCD00077413
- MOL File:
- 125700-67-6.mol
- MSDS File:
- SDS
Last updated:2025-09-25 17:15:13
| Product description | Number | Pack Size | Price |
| TBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem® | 8.51008 | 25 g | $64.3 |
| TBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem® | 8.51008 | 100 g | $198 |
| TBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem® | 8.51008 | 1 kg | $444 |
| O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate ≥97.0% (N) | 12806 | 5G | $70.3 |
| O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate ≥97.0% (N) | 12806 | 25g | $193 |
| More product size | |||
| Melting point | 205 °C (dec.)(lit.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | acetonitrile: 0.1 g/mL, clear |
| form | Powder |
| color | White to Almost white |
| Water Solubility | Soluble in acetonitrile (100 mg/ml, clear, colorless), DMF (160.55 mg/ml, clear), and water (3 mg/ml at 20°C). |
| Sensitive | Moisture Sensitive |
| BRN | 7066325 |
| InChI | InChI=1S/C11H16N5O.BF4/c1-13(2)11(14(3)4)15-9-7-5-6-8-10(9)16(17)12-15;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1 |
| InChIKey | NQGZJNPFMLJDKU-UHFFFAOYSA-M |
| SMILES | [B+3]([F-])([F-])([F-])[F-].C(=[N+]1/N=N(=O)C2=CC=CC=C/12)(\N(C)C)/N(C)C |
| LogP | -2.65 at 21℃ |
| CAS DataBase Reference | 125700-67-6(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, tetrafluoroborate(1-) (1:1) (125700-67-6) |
| UNSPSC Code | 12352107 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H228-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P240-P241-P261-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,F,E | |||||||||
| Risk Statements | 36/37/38-5-2 | |||||||||
| Safety Statements | 26-36-37/39-36/37/39-35 | |||||||||
| RIDADR | 1325 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10-21 | |||||||||
| Hazard Note | Irritant/Flammable | |||||||||
| HS Code | 2933 99 80 | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | Ⅱ | |||||||||
| Limited Quantities | 1.0 Kg (2.2 lbs) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
TBTU price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.51008 | TBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem® | 125700-67-6 | 25 g | $64.3 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.51008 | TBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem® | 125700-67-6 | 100 g | $198 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.51008 | TBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem® | 125700-67-6 | 1 kg | $444 | 2025-07-31 | Buy |
| Sigma-Aldrich | 12806 | O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate ≥97.0% (N) | 125700-67-6 | 5G | $70.3 | 2025-07-31 | Buy |
| Sigma-Aldrich | 12806 | O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate ≥97.0% (N) | 125700-67-6 | 25g | $193 | 2025-07-31 | Buy |
TBTU Chemical Properties,Uses,Production
Chemical Properties
TBTU [chemical name:2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate] is WHITE TO PALE CREAM FINE CRYSTALLINE POWDER
Uses
TBTU is a coupling reagent for peptide synthesis causing low racemization, which is ideally suited for solid-phase peptide synthesis. Also used in the synthesis of acid based t-antigen glycodendrimers.
reaction suitability
reaction type: Coupling Reactions
TBTU Preparation Products And Raw materials
Global( 597)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co.,Ltd. | +86-0512-68071238 +86-13771819922 | june@highfine.com | China | 458 | 58 |
| Xinxiang Juyuan Biological Technology Co., Ltd. | +8615637360870 | sales@xxkfqchem.com | China | 12 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8772 | 58 |
| Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 | market02@senwayer.com | China | 922 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20175 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13456 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
Related Qustion
Ask a questionQ:How TBTU working in peptide synthesis?Anonymous - Aug 20，2025
A:During peptide synthesis, TBTU forms carboxylic acid active esters, and then obtains amide compounds under the attack of nucleophilic reagents. It shows high coupling efficiency, fast kinetics, high yields and low racemisation.
Q:What does TBTU mean in chemistry?Anonymous - Aug 20，2025
A:In chemistry, TBTU generally refers to O-(Benzotriazol-1-yl)-N,N,N',N'-tetra methyluronium tetrafluoroborate, a peptide coupling reagent. It is used for solid-phase peptide synthesis.
View Lastest Price from TBTU manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-16 | TBTU
125700-67-6
|
US $700.00 / KG | 1KG | 99 | 50TONS | Xinxiang Juyuan Biological Technology Co., Ltd. | |
 |
2025-10-16 | 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
125700-67-6
|
US $12.00-11.00 / KG | 1KG | 99% | 200mt | Jinan Finer Chemical Co., Ltd | |
 |
2025-10-11 | 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
125700-67-6
|
US $0.00-0.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- TBTU
125700-67-6
- US $700.00 / KG
- 99
- Xinxiang Juyuan Biological Technology Co., Ltd.
-
- 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
125700-67-6
- US $12.00-11.00 / KG
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
125700-67-6
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
125700-67-6(TBTU)Related Search:
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AZURE B TETRAFLUOROBORATE
1,1,3,3-Tetramethylurea
1H-Benzotriazole
5-Methyl-1H-benzotriazole
Ribavirin
1,2,3-1H-Triazole
O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
1of4
benzotriazol-1-yl-tetramethyluroniumtetrafluoroborate
[benzotriazol-1-yloxy(dimethylamino)methylene]-dimethyl-ammonium
1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-Oxide Tetrafluoroborate
O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM TETRAFLUOROBORATE
O-(1H-BENZOTRIAZOLE-1-YL) N,N,N',N'-TETRAMETHYL URONIUM TETRAFLUOROBORATE
O-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYL-URONIUM TETRAFLUOROBORATE
O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-PENTAMETHYLENE-URONIUM TETRAFLUOROBORATE
O-(1H-BENZO-1,2,3-TRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYL-URONIUM TETRAFLUOROBORATE
O-(BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE
N-[(1H-BENZOTRIAZOL-1-YL)(DIMETHYL-AMINO)METHYLENE]-N-METHYL-METHANAMINIUM TETRAFLUOROBORATE
TBPIPU
TBTU
TETRAFLUOROBORATE TBTU
O-BENZOTRIAZOL-1-YL-N,N,N',N'-TETRA- &
O-BENZOTRIAZOL-1-YL-N,N,N',N'-TETRAMETHY LURONIUM
TBTU,O-(BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM TETRAFLUOROBORATE
O-Benzotriazol-lYL-N,N',N'-Tetramethyluronium Tetrafluoroborate
2-(1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE (TBTU)
O-Benzotriazol-1-yl-N,N,N',N'-tetramethylisouronium tetrafluoroborate
TBTU/2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumtetrafluoroborate
O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluro
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetraMethyluroni
1H-BenzotriazoliuM-1-[bis(diMethylaMine)
2-(1H-Benzo[d][1,2,3]triazol-1-yl)-1,1,3,3-tetraMethyluroniuM tetrafluoroborate
TBTU, [(1H-Benzotriazol-1-yl)oxy](dimethylamino)-N,N-dimethylmethaniminium tetrafluoroborate
O-(BENZOTRIAZOLE-1-YL)-N,N,N',N'-TETRAMETHYL URONIUM TETRAFLUORO BORATE
KNORR REAGENT
2-(1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE
2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE
O-(Benzotriazol-1-yl)-N,N,N',N'-tetraMethyluroniuM tetrafluoroborate >=97.0% (N)
3-[(dimethylamino)(dimethyliminiumyl)methyl]-1-oxo-2,3-dihydro-1H-1λ?,2,3-benzotriazol-1-ylium-2-ide
2-(1H-Benzotriazole-1-yl)-1,1,3,3-Tetram
TBTU (Knorr reagent)
O-(1H-BENZOTRIAZOL-1-YL)-N,N,N'',N''-TETRAMETHYLURONIUM TETRAFLUOROBORATE(TBTU)
O-Benzotriazol-l-yl- N,N,N'',N'',- tetramethyluroniumtetrafluoroborate
O-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium Tetrafluoroborate (TBTU)
TDBTU (O-(3,4-DIHYDRO-4-OXO-1,2,3-BENZOTRIAZIN-3-YL)-N,N,N'',N''-TETRAMETHYLURONIUM TETRAFLUOROBORATE)
N-[(1H-Benzotriazol-1-yl)(dimethylamino)methylene]-N-methylmethanaminium tetrafluoroborate N-oxide
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate [Coupling Reagent for Peptide]
TBTU extrapure
benzotriazolyl tetramethyluronium fluoroborate
2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, 97+%
TBTU (o-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafluo
benzotriazol-1-yl-N-tetramethyl-uronium tetrafluoroborate
O-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafluoroborate,97%
O-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetraMethyluroniuM tetrafluoroborate, 99%, 99%
TBTU 99.5%
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate≥ 98% (HPLC)
N,N,N′,N′-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate
TBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem
O-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate for synthesis
(Benzotriazol-1-yloxy-dimethylamino-methylene)dimethylammonium tetrafluoroborate
[dimethylamino-(3-oxidobenzotriazol-3-ium-1-yl)methylidene]-dimethylazanium
TBTU [Coupling Reagent for Peptide]
O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM TETRAFL
TBTU, N,N,Nμ,Nμ-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Tetrafluoroborate [Coupling Reagent for Peptide]>
TBTU N
