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Fmoc-Trp(Boc)-OH

Fmoc-Trp(Boc)-OH Structure
Fmoc-Trp(Boc)-OH structure
CAS No.
143824-78-6
Chemical Name:
Fmoc-Trp(Boc)-OH
Synonyms
FMOC-L-TRP(BOC)-OH;FMOC-TRP(BOC);FMOC-L-TRP(BOC);N1-Boc-NaL;pha-Fmoc-L;FMOC-TRP(BOC)-OH;Fomc-Trp(Boc)-OH;Fmoc-Trp(Boc)-0H;FMOC-L-TRYPTOPHANE;FMOC-L-TRP(TBOC)-OH
CBNumber:
CB3360314
Molecular Formula:
C31H30N2O6
Molecular Weight:
526.58
MDL Number:
MFCD00153366
MOL File:
143824-78-6.mol
MSDS File:
SDS
Last updated:2025-07-16 10:00:26
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Fmoc-Trp(Boc)-OH Properties

Melting point ca 97℃
alpha -21 º (c=1%, DMF)
Density 1.28±0.1 g/cm3(Predicted)
refractive index -20 ° (C=1, DMF)
storage temp. 2-8°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka 3.71±0.10(Predicted)
form Solid
color White to Orange to Green
optical activity [α]20/D 21±2°, c = 1% in DMF
Sensitive Moisture Sensitive
BRN 7698009
InChI InChI=1S/C31H30N2O6/c1-31(2,3)39-30(37)33-17-19(20-10-8-9-15-27(20)33)16-26(28(34)35)32-29(36)38-18-25-23-13-6-4-11-21(23)22-12-5-7-14-24(22)25/h4-15,17,25-26H,16,18H2,1-3H3,(H,32,36)(H,34,35)/t26-/m0/s1
InChIKey ADOHASQZJSJZBT-SANMLTNESA-N
SMILES C(O)(=O)[C@H](CC1C2=C(C=CC=C2)N(C(OC(C)(C)C)=O)C=1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference 143824-78-6(CAS DataBase Reference)
FDA UNII X3V4CFM5R8
UNSPSC Code 12352209
NACRES NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H317-H401-H411
Precautionary statements  P261-P280g-P302+P352a-P321-P333+P313-P501a
Hazard Codes  Xi,N
Risk Statements  36/37/38-51/53-43
Safety Statements  22-24/25-36/37/39-27-26-61-37-24
RIDADR  3077
WGK Germany  3
F  10-21
HazardClass  9
HS Code  29339900
NFPA 704
1
2 0

Fmoc-Trp(Boc)-OH price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.52050 Fmoc-Trp(Boc)-OH Novabiochem? 143824-78-6 25g $201 2025-07-31 Buy
Sigma-Aldrich 8.52050 Fmoc-Trp(Boc)-OH Novabiochem? 143824-78-6 100g $525 2025-07-31 Buy
Sigma-Aldrich 8.52050 Fmoc-Trp(Boc)-OH Novabiochem? 143824-78-6 250g $1120 2025-07-31 Buy
Sigma-Aldrich 8.52050 Fmoc-Trp(Boc)-OH Novabiochem® 143824-78-6 500 g $2220 2025-07-31 Buy
Sigma-Aldrich 8.52050 Fmoc-Trp(Boc)-OH Novabiochem® 143824-78-6 500 g $2220 2025-07-31 Buy
Product number Packaging Price Buy
8.52050 25g $201 Buy
8.52050 100g $525 Buy
8.52050 250g $1120 Buy
8.52050 500 g $2220 Buy
8.52050 500 g $2220 Buy

Fmoc-Trp(Boc)-OH Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

Fmoc-Trp(Boc)-OH is a very useful synthetic intermediate. It is used to prepare Trp containing-peptides.

Uses

Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of glucagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes and various peptides by Fmoc solid phase peptide synthesis (SPPS).

General Description

The use of Fmoc-Trp(Boc)-OH overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

The synthesis of Fmoc-Trp(Boc)-OH typically begins with tryptophan, which is then selectively protected using the Boc group. The Fmoc group is introduced through a reaction with 9-fluorenylmethoxycarbonyl chloride.

Fmoc-Trp(Boc)-OH synthesis

405555-31-9
4425-82-5
143824-78-6
Synthesis of Fmoc-Trp(Boc)-OH from tert-butyl 3-[(2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-methoxy-3-oxopropyl]indole-1-carboxylate

Fmoc-Trp(Boc)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

L-Phe-D-Trp-OH Fmoc-β-HomoTrp(Boc)-OH

Fmoc-Trp(Boc)-OH Suppliers

Global( 509)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu ZY Biochemical Technology Co., Ltd. 		+86-86-2888626688 +8618980008884 xuehaiying@zybiochem.com China 176 58
Chemtour Biotech Co., Ltd
+8617327281506 market@chemtour.com China 1521 58
Wuhan senwayer century chemical Co.,Ltd 		+undefined-27-86652399 +undefined13627115097 market02@senwayer.com China 922 58
Sichuan HongRi Pharma-Tech Co.,Ltd 		+8617390183901 cynthia@enlaibio.com China 1100 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20202 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29733 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 12887 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21622 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Supplier Advantage
Chengdu ZY Biochemical Technology Co., Ltd. 		58
Chemtour Biotech Co., Ltd
58
Wuhan senwayer century chemical Co.,Ltd 		58
Sichuan HongRi Pharma-Tech Co.,Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60

Related articles

View Lastest Price from Fmoc-Trp(Boc)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fmoc-Trp(Boc)-OH pictures 2025-08-15 Fmoc-Trp(Boc)-OH
143824-78-6
 US $0.00 / Kg/Drum 1KG 98%min 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
Fmoc-Trp(Boc)-OH pictures 2025-08-15 Fmoc-Trp(Boc)-OH
143824-78-6
 US $0.00-0.00 / kg 1kg 98% 1T Sichuan HongRi Pharma-Tech Co.,Ltd
Fmoc-Trp(Boc)-OH pictures 2025-08-15 Fmoc-Trp(Boc)-OH
143824-78-6
 US $5.00 / kg 1kg ≥99% 100mt/year Jinan Finer Chemical Co., Ltd
  • Fmoc-Trp(Boc)-OH pictures
  • Fmoc-Trp(Boc)-OH
    143824-78-6
  • US $0.00 / Kg/Drum
  • 98%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Fmoc-Trp(Boc)-OH pictures
  • Fmoc-Trp(Boc)-OH
    143824-78-6
  • US $0.00-0.00 / kg
  • 98%
  • Sichuan HongRi Pharma-Tech Co.,Ltd

Fmoc-Trp(Boc)-OH Spectrum

Fmoc-Trp(Boc)-OH(143824-78-6)1HNMRFmoc-Trp(Boc)-OH(143824-78-6)1HNMR

143824-78-6(Fmoc-Trp(Boc)-OH)Related Search:

Fmoc-Lys(Boc)-OH L-Tryptophan BUTYL OLEATE 9-Fluorenylmethyl chloroformate tert-Butyl acetate
N-(tert-Butoxycarbonyl)-L-alanine L-5-Hydroxytryptophan Fmoc-Phe-OH Nalpha-Fmoc-Ndelta-trityl-L-glutamine L-Fmoc-Aspartic acid alpha-tert-butyl ester
METHOXYCARBONYLSULFENYL CHLORIDE Cyhalofop-butyl Butyl acetate N-(9-Fluorenylmethoxycarbonyloxy)succinimide Boc-Aib-OH
2-Butoxyethanol Buprofezin tert-Butanol

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FMOC-TRP(BOC)-OH FMOC-TRP(BOC) FMOC-TRYPTOPHAN(BOC)-OH FMOC-NIN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN FMOC-N-IN-BOC-L-TRYPTOPHAN FMOC-N-BOC-L-TRYPTOPHAN FMOC-L-TRP(BOC) FMOC-L-TRP(BOC)-OH FMOC-L-TRYPTOPHAN(BOC) FMOC-L-TRYPTOPHAN (TBOC) FMOC-L-TRP(TBOC)-OH N-ALPHA-FMOC-N-IN-T-BOC-L-TRYPTOPHAN N-ALPHA-FMOC-N(IN)-BOC-L-TRYPTOPHAN N-ALPHA-FMOC-N-IN-TERT-BOC-L-TRYPTOPHAN N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-IN-T-BUTOXYCARBONYL-L-TRYPTOPHAN N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-NIN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-IN-T-BUTYL-OXYCARBONYL-L-TRYPTOPHAN NALPHA-9-FLUORENYLMETHYLOXYCARBONYL-N(IN)-TERT-BUTOXYCARBONYL-L-TRYPTOPHAN N ALPHA-9-FLUORENYLMETHYLOXYCARBONYL-N(IN)-T-BUTOXYCARBONYL-L-TRYPTOPHAN Fmoc-Trp(Boc)-OH ,98% FMoc-Trp(Boc)-OH N-α-FMoc-N-in-Boc-L-tryptophan 1-Boc-N^a-FMoc-L-tryptophan, 97% 1-Boc-N-FMoc-L-tryptophan, 97% N1-Boc-Nalpha-Fmoc-L-tryptophan Fmoc-Trp(Boc)-OH Fmoc-Trp(Boc)-OH >=97.0% (HPLC) (2S)-3-{1-[(tert-Butoxy)carbonyl]-1H-indol-3-yl}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid Nα-Fmoc-Nin-Boc-L-tryptophan≥ 98% (HPLC) (9H-Fluoren-9-yl)MethOxy]Carbonyl Trp(Boc)-OH N-Fmoc-NIn-Boc-L-trp Fmoc-Trp(Boc)-OH (contains 8% solvents) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]propanoic acid (2R)-3-{1-[(tert-butoxy)carbonyl]-1H-indol-3-yl}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid Fmoc-Trp(Boc)-OH, 97.0% (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)propanoicacid N(in)-Boc-Nα-Fmoc-L-tryptophan Nα-Fmoc-N(in)-Boc-L-tryptophan N-tert-Butoxycarbonyl-N-9-fluorenylmethoxycarbonyl-L-tryptophan N-α-Fmoc-N-in-Boc-L-tryptophan FMOC-TRP(BOC)-OH 99+% N-ALPHA-(9-FLUOROENYLMETHYLOXYCARBONYL)-N-IN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN FMOC-L-TRYPTOPHANE N (in) -Boc- N α -Fmoc- L -tryptophan Nin-tert-Butoxycarbonyl-NALPHA-9-fluorenylmethoxycarbonyl-L-tryptophan FMOC-N-BOC-L-TRYPTOPHAN (FMOC-L-TRP(BOC)-OH) 1-[(TERT-BUTYL)CARBONYL]-N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-TRYPTOPHAN Nα-Fmoc-N(in)-Boc-L-tryptophan, N(in)-Boc-Nα-Fmoc-L-tryptophan N1-Boc-Nalpha-Fmoc-L-tryptophan Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N1-tert-butoxycarbonyl-L-tryptophan N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-IN-TERT-BUTYLOXYCARBONYL-L-TRYPTOPHAN N(IN)-BOC-N-ALPHA-FMOC-L-TRYPTOPHAN Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N1-tert-butoxycarbonyl-L-tryptophan> FMOC-TRP(BOC)-OH 25 G FMOC-TRP(BOC)-OH 100 G N1-Boc-NaL pha-Fmoc-L L-Tryptophan, 1-[(1,1-dimethylethoxy)carbonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]- N(α)-fmoc-N(in)-boc-L-tryptophan (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]propanoicaci