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4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester structure

CAS No.: 304897-49-2

Chemical Name:: 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester

Synonyms: 4-(4-Boc-piperazin-1-yl-methyl)aniline;4-[(4-Boc-1-piperazinyl)methyl]aniline;4-(1-BOC-PIPERAZIN-4-YL-METHYL)-ANILINE;4-(4-Aminobenzyl)piperazine, N1-BOC protected;4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline;tert-butyl 4-(4-aMinobenzyl)piperazine-1-carboxylate;4-(4-aminobenzyl)piperazine-1-carboxylic acid tertbut;ert-butyl4-[(4-aminophenyl)methyl]piperazine-1-carboxylate;tert-butyl 4-[(4-aMinophenyl)Methyl]piperazine-1-carboxylate;4-(4-AMINOBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

CBNumber:: CB3386716

Molecular Formula:: C16H25N3O2

Molecular Weight:: 291.39

MDL Number:: MFCD06797795

MOL File:: 304897-49-2.mol

MSDS File:: SDS

Last updated:2025-08-08 17:45:00

Product description	Number	Pack Size	Price
4-(4-Aminobenzyl)piperazine-1-carboxylicacidtert-butylester	A593945	100mg	$45
tert-Butyl 4-[(4-aminophenyl)methyl]piperazine-1-carboxylate 98%	4H56-1-46	250mg	$70
4-(1-Boc-piperazin-4-yl-methyl)aniline	FB51992	250mg	$70
4-(1-Boc-piperazin-4-yl-methyl)aniline,95%(NMR) 95%(NMR)	20156	250MG	$86.91
4-(1-Boc-piperazin-4-yl-methyl)aniline	FB51992	500mg	$110
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4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Properties

Boiling point	413.6±40.0 °C(Predicted)
Density	1.136±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	solid
pka	7.16±0.10(Predicted)
Appearance	White to yellow Solid
UNSPSC Code	12352108

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2933599590

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A593945	4-(4-Aminobenzyl)piperazine-1-carboxylicacidtert-butylester	304897-49-2	100mg	$45	2021-12-16	Buy
SynQuest Laboratories	4H56-1-46	tert-Butyl 4-[(4-aminophenyl)methyl]piperazine-1-carboxylate 98%	304897-49-2	250mg	$70	2021-12-16	Buy
Biosynth Carbosynth	FB51992	4-(1-Boc-piperazin-4-yl-methyl)aniline	304897-49-2	250mg	$70	2021-12-16	Buy
Chem-Impex	20156	4-(1-Boc-piperazin-4-yl-methyl)aniline,95%(NMR) 95%(NMR)	304897-49-2	250MG	$86.91	2021-12-16	Buy
Biosynth Carbosynth	FB51992	4-(1-Boc-piperazin-4-yl-methyl)aniline	304897-49-2	500mg	$110	2021-12-16	Buy

Product number	Packaging	Price	Buy
A593945	100mg	$45	Buy
4H56-1-46	250mg	$70	Buy
FB51992	250mg	$70	Buy
20156	250MG	$86.91	Buy
FB51992	500mg	$110	Buy

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production

Uses

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester is a carboxylic acid ester derivative and can be used as a pharmaceutical intermediate.

Synthesis

4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

130636-61-2

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester

304897-49-2

Tert-butyl 4-(4-nitrobenzyl)piperazine-1-carboxylate (1.100 g, 3.423 mmol) was added to a solvent mixture of tetrahydrofuran solution (20 mL) of ammonium chloride (0.915 g, 17.114 mmol) and zinc powder (1.119 g, 17.114 mmol) with water (20 mL) as starting material, and the reaction was stirred for 12 h at room temperature. . Upon completion of the reaction, the reaction mixture was filtered to remove solid impurities. Water was added to the filtrate and subsequently extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting product, tert-butyl 4-(4-aminobenzyl)piperazine-1-carboxylate (0.900 g, 90.2% yield), was a yellow solid and could be used in subsequent reactions without further purification.

References

[1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 19, p. 5592 - 5599
[2] Patent: US2004/34033, 2004, A1. Location in patent: Page/Page column 12; Sheet 1
[3] Patent: WO2017/18803, 2017, A1. Location in patent: Paragraph 1492; 1493; 1494
[4] Patent: WO2016/146220, 2016, A1. Location in patent: Page/Page column 26; 27
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1499 - 1518

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

4-(4-NITROBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Water ZINC Tetrahydrofuran Ammonium chloride

Preparation Products

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Suppliers

Global( 125)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-17392712697	1022@dideu.com	China	3995	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8725	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52725	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Shanghai UCHEM Inc.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
Labnetwork lnc.	58

View Lastest Price from 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-24	4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester 304897-49-2	US $0.10 / KG	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
2025-11-18	4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester 304897-49-2	US $1.10 / g	1g	99.00%	100 Tons	Dideu Industries Group Limited
2019-12-20	4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester 304897-49-2	US $1.00 / KG	1KG	99%	KG/T	Career Henan Chemical Co

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
304897-49-2
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
304897-49-2
US $1.10 / g
99.00%
Dideu Industries Group Limited

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
304897-49-2
US $1.00 / KG
99%
Career Henan Chemical Co

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Spectrum

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester(304897-49-2)¹HNMR

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4-(4-AMINOBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+% 4-(4-AMINOBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(1-BOC-PIPERAZIN-4-YL-METHYL)-ANILINE 4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline 4-(4-Aminobenzyl)piperazine, N1-BOC protected tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate, 4-{[4-(tert-Butoxycarbonyl)piperazin-1-yl]methyl}aniline 4-(4-Boc-piperazin-1-yl-methyl)aniline tert-butyl 4-(4-aMinobenzyl)piperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-[(4-aMinophenyl)Methyl]-, 1,1-diMethylethyl ester tert-butyl 4-[(4-aMinophenyl)Methyl]piperazine-1-carboxylate 4-(4-aminobenzyl)piperazine-1-carboxylic acid tertbut ert-butyl4-[(4-aminophenyl)methyl]piperazine-1-carboxylate 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester ISO 9001：2015 REACH 4-[(4-Boc-1-piperazinyl)methyl]aniline 304897-49-2