Orphenadrine citrate
- CAS No.
- 4682-36-4
- Chemical Name:
- Orphenadrine citrate
- Synonyms
- X-Ota;Flexon;X-Otag;Banflex;Benhexal;Flexoject;Einecs 225-137-5;Orphenadrine citrate;ORPHENADRINECITRATE,USP;Orphenadrine citrate CRS
- CBNumber:
- CB3401680
- Molecular Formula:
- C18H23NO.C6H8O7
- Molecular Weight:
- 461.51
- MDL Number:
- MFCD00079197
- MOL File:
- 4682-36-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 132-1340C |
|---|---|
| storage temp. | Sealed in dry,2-8°C |
| solubility | Sparingly soluble in water, slightly soluble in ethanol (96 per cent). |
| form | Solid |
| color | White to Pale Beige |
| Major Application |
forensics and toxicology pharmaceutical (small molecule) |
| InChIKey | ASDBZPGDZBFZAH-UHFFFAOYSA-N |
| SMILES | OC(=O)CC(CC(O)=O)C(O)=O.CN(C)CCOC(c1ccccc1)c2ccccc2C |
| CAS DataBase Reference | 4682-36-4(CAS DataBase Reference) |
| FDA UNII | X0A40N8I4S |
| NCI Drug Dictionary | orphenadrine citrate |
| ATC code | M03BC01 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-40-20/21/22 |
| Safety Statements | 22-36-62-38-36/37/39-28-26-24/25 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2922190900 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
Orphenadrine citrate price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000101 | Orphenadrine citrate European Pharmacopoeia (EP) Reference Standard | 4682-36-4 | 100 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | O4630 | Orphenadrine citrate salt analytical standard | 4682-36-4 | 5g | $79.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1479009 | Orphenadrine citrate salt United States Pharmacopeia (USP) Reference Standard | 4682-36-4 | 200mg | $422 | 2026-04-30 | Buy |
| Cayman Chemical | 39028 | Orphenadrine (citrate) ≥98% | 4682-36-4 | 25mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 39028 | Orphenadrine (citrate) ≥98% | 4682-36-4 | 50mg | $88 | 2026-04-30 | Buy |
Orphenadrine citrate Chemical Properties, Uses, Production
Chemical Properties
White Solid
Originator
Norflex,Riker,US,1959
Uses
Muscle relaxant (skeletal); antihistaminic
Uses
skeletal muscle relaxant, antihistaminic agent
Uses
A histaminergic compound
Definition
ChEBI: A citrate salt which comprises equimolar amounts of orphenadrine and citric acid.
Manufacturing Process
As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid.
brand name
Norflex (3M Pharmaceuticals).
Therapeutic Function
Muscle relaxant
General Description
Orphenadrine citrate, N,Ndimethyl-2-(o-methyl-α-phenylbenzyloxy)ethylamine citrate(1:1) (Norflex), introduced in 1957, is closely related todiphenhydramine structurally but has much lower antihistaminicactivity and much higher anticholinergic action.Likewise, it lacks the sedative effects characteristic ofdiphenhydramine. Pharmacological testing indicates that itis not primarily a peripherally acting anticholinergic becauseit has only weak effects on smooth muscle, on the eye,and on secretory glands. It does reduce voluntary musclespasm, however, by a central inhibitory action on cerebralmotor areas, a central effect similar to that of atropine.
Biological Activity
Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.
Clinical Use
Orphenadrine citrate is used for the symptomatic treatment ofParkinson disease. It relieves rigidity better than it doestremor, and in certain cases, it may accentuate the latter. Thedrug combats mental sluggishness, akinesia, adynamia, andlack of mobility, but this effect seems to diminish rather rapidlywith prolonged use. It is best used as an adjunct to theother agents, such as benztropine, procyclidine, cycrimine,and trihexyphenidyl, in the treatment of paralysis agitans.Orphenadrine citrate is also used as an adjunct to rest, physiotherapy,and other measures to relieve pain of local musclespasm (e.g., nocturnal leg cramps).
The drug has a low incidence of the usual side effectsfor this group, namely, dryness of mouth, nausea, and mildexcitation.
Orphenadrine citrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
View Latest Price from Orphenadrine citrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | Orphenadrine Citrate
4682-36-4
|
$1.00-22.00 | 1KG | 99% | 100000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-07-16 | Orphenadrine Citrate
4682-36-4
|
$31.00 | 98.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-01-12 | Orphenadrine Citrate
4682-36-4
|
$10.00 | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd |
-
- Orphenadrine Citrate
4682-36-4
- $1.00-22.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Orphenadrine Citrate
4682-36-4
- $31.00
- 98.00%
- TargetMol Chemicals Inc.
-
- Orphenadrine Citrate
4682-36-4
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
