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BNP-32 (RAT)

CAS No.
133448-20-1
Chemical Name:
BNP-32 (RAT)
Synonyms
BNP RAT;BNP-32 (RAT);BNP (1-32) RAT;BNP (51-95), RAT;BNP-32 (rat) trifluoroacetate;NSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF;Brain Natriuretic Peptide (1-32);BRAIN NATRIURETIC PEPTIDE-32 (RAT);Rat brain natriuretic peptide(1-32);BRAIN NATRIURETIC PEPTIDE (1-32), RAT
CBNumber:
CB3403598
Molecular Formula:
C146H239N47O44S3
Molecular Weight:
3452.94
MDL Number:
MFCD00133150
MOL File:
133448-20-1.mol
MSDS File:
SDS
Last updated:2025-06-18 16:39:20
Product description Number Pack Size Price
BNP-32 (rat) trifluoroacetate FB109674 500ug $550
BNP (1-32), RAT 95.00% PEP0003941 0.5MG $950
Brain Natriuretic Peptide (1-32), rat CS-0044640 5mg $1100
BNP (1-32), RAT 95.00% PEP0003941 1MG $1360
BNP (1-32), RAT 95.00% PEP0003941 2.5MG $2800

BNP-32 (RAT) Properties

Density 1.50±0.1 g/cm3(Predicted)
storage temp. -20°C
form powder
Water Solubility Soluble in Water
Sequence Asn-Ser-Lys-Met-Ala-His-Ser-Ser-Ser-Cys-Phe-Gly-Gln-Lys-Ile-Asp-Arg-Ile-Gly-Ala-Val-Ser-Arg-Leu-Gly-Cys-Asp-Gly-Leu-Arg-Leu-Phe (Disulfide bridge: Cys10-Cys26)
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

WGK Germany  3

BNP-32 (RAT) price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth Carbosynth FB109674 BNP-32 (rat) trifluoroacetate 133448-20-1 500ug $550 2021-12-16 Buy
American Custom Chemicals Corporation PEP0003941 BNP (1-32), RAT 95.00% 133448-20-1 0.5MG $950 2021-12-16 Buy
ChemScene CS-0044640 Brain Natriuretic Peptide (1-32), rat 133448-20-1 5mg $1100 2021-12-16 Buy
American Custom Chemicals Corporation PEP0003941 BNP (1-32), RAT 95.00% 133448-20-1 1MG $1360 2021-12-16 Buy
American Custom Chemicals Corporation PEP0003941 BNP (1-32), RAT 95.00% 133448-20-1 2.5MG $2800 2021-12-16 Buy
Product number Packaging Price Buy
FB109674 500ug $550 Buy
PEP0003941 0.5MG $950 Buy
CS-0044640 5mg $1100 Buy
PEP0003941 1MG $1360 Buy
PEP0003941 2.5MG $2800 Buy

BNP-32 (RAT) Chemical Properties,Uses,Production

Uses

Brain Natriuretic Peptide (1-32), rat (BNP (1-32), rat) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes)[1].

Biochem/physiol Actions

Brain natriuretic peptide (type B natriuretic peptide) was originally isolated from brain, but is mainly produced in myoendocrine cells of the heart ventricles from which it is released into the circulation. It is involved in blood pressure control and cardiovascular homeostasis.

in vivo

The depressor, natriuretic and cyclic GMP responses to several species of brain natriuretic peptide (BNP) are compared to atrial natriureticpeptide (ANP) 99-126 in conscious spontaneously hypertensive rats (SHR) and in conscious cynomolgus monkeys treated with vehicle or the selective neutral endopeptidase inhibitor SQ 28603. In the conscious SHR, the natriuretic and cyclic GMP responses to 3 nmol/kg i.v. rat BNP (1-32) greater than rat ANP 99-126 greater than pig BNP-26 and sre significantly potentiated by 100 mumol/kg i.v. SQ 28,603. Human BNP-32 is inactive in the SHR treated with either vehicle or SQ 28,603. In contrast, 1 nmol/kg i.v. of human BNP (1-32) stimulates renal and depressor responses in the conscious monkeys that are greater than or equal to those elicited by human ANP 99-126, whereas 3 nmol/kg i.v. rat BNP (1-32) reduces mean arterial pressure without affecting renal function[3].

References

[1] Dickey DM, et al. Human B-type natriuretic peptide is not degraded by meprin A. Biochem Pharmacol. 2010 Oct 1;80(7):1007-11. DOI:10.1016/j.bcp.2010.06.015
[2] Wellard J, et al. Natriuretic peptides, but not nitric oxide donors, elevate levels of cytosolic guanosine 3',5'-cyclic monophosphate in ependymal cells ex vivo. Neurosci Lett. 2006 Jan 16;392(3):187-92. DOI:10.1016/j.neulet.2005.09.084
[3] Seymour AA, et al. Potentiation of brain natriuretic peptides by SQ 28,603, an inhibitor of neutral endopeptidase3.4.24.11, in monkeys and rats. J Pharmacol Exp Ther. 1992 Jul;262(1):60-70. PMID:1385630

BNP-32 (RAT) Preparation Products And Raw materials

Raw materials

Preparation Products

BNP-32 (RAT) Suppliers

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H-ASN-SER-LYS-MET-ALA-HIS-SER-SER-SER-CYS-PHE-GLY-GLN-LYS-ILE-ASP-ARG-ILE-GLY-ALA-VAL-SER-ARG-LEU-GLY-CYS-ASP-GLY-LEU-ARG-LEU-PHE-OH H-ASN-SER-LYS-MET-ALA-HIS-SER-SER-SER-CYS-PHE-GLY-GLN-LYS-ILE-ASP-ARG-ILE-GLY-ALA-VAL-SER-ARG-LEU-GLY-CYS-ASP-GLY-LEU-ARG-LEU-PHE-OH (DISULFIDE BRIDGE: 10-26) H-ASN-SER-LYS-MET-ALA-HIS-SER-SER-SER-CYS-PHE-GLY-GLN-LYS-ILE-ASP-ARG-ILE-GLY-ALA-VAL-SER-ARG-LEU-GLY-CYS-ASP-GLY-LEU-ARG-LEU-PHE-OH, (DISULFIDE BOND) B-TYPE (BRAIN) NATRIURETIC PEPTIDE-32 (RAT) BRAIN NATRIURETIC PEPTIDE-32 (RAT) BRAIN NATRIURETIC PEPTIDE (1-32), RAT BNP (1-32) RAT BNP RAT BNP (51-95), RAT BNP-32 (RAT) ASN-SER-LYS-MET-ALA-HIS-SER-SER-SER-CYS-PHE-GLY-GLN-LYS-ILE-ASP-ARG-ILE-GLY-ALA-VAL-SER-ARG-LEU-GLY-CYS-ASP-GLY-LEU-ARG-LEU-PHE NSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF NSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF (DISULFIDE BRIDGE: 10-26) 14-45-Brain natriuretic peptide-45 (rat) Rat brain natriuretic peptide(1-32) L-Asn-L-Ser-L-Lys-L-Met-L-Ala-L-His-L-Ser-L-Ser-L-Ser-L-Cys(1)-L-Phe-Gly-L-Gln-L-Lys-L-Ile-L-Asp-L-Arg-L-Ile-Gly-L-Ala-L-Val-L-Ser-L-Arg-L-Leu-Gly-L-Cys(1)-L-Asp-Gly-L-Leu-L-Arg-L-Leu-L-Phe-OH ASN-SER-LYS-MET-ALA-HIS-SER-SER-SER-CYS-PHE-GLY-GLN-LYS-ILE-ASP-ARG-ILE-GLY-ALA-VAL-SER-ARG-LEU-GLY-CYS-ASP- GLY-LEU-ARG-LEU-PHE(DISULFIDE BRIDGE:CYS10-CYS26) BNP-32 (rat) Brain Natriuretic Peptide-32 (rat) BNP-32 (rat) trifluoroacetate Brain Natriuretic Peptide (BNP) (1-32), rat Brain natriuretic peptide-32 rat, ≥97% (HPLC) 14-45-Brain natriuretic peptide-45 (rat) (9CI) Brain Natriuretic Peptide-32 rat >=97% (HPLC), powder Brain Natriuretic Peptide (1-32) ASN-SER-LYS-MET-ALA-HIS-SER-SER-SER-CYS-PHE-GLY-GLN-LYS-ILE-ASP-ARG-ILE-GLY-ALA-VAL-SER-ARG-LEU-GLY-CYS-ASP-GLY-LEU-ARG-LEU-PHE 133448-20-1 C146H239N47O44S3 BioChemical Amino Acids and Peptides Biochemicals and Reagents Natriuretic Peptides Peptides Peptide