Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>N-Acetyl-D-leucine

N-Acetyl-D-leucine

N-Acetyl-D-leucine Structure
N-Acetyl-D-leucine structure
CAS No.
19764-30-8
Chemical Name:
N-Acetyl-D-leucine
Synonyms
AC-D-LEU-OH;ACETYL-D-LEUCINE;N-Ac-D-Leu-OH;N-Ac-D-Leucine;(2R)-2-acetamido-4-methylpentanoic acid;AC-D-LEUCINE;Ace-D-Leu-OH;N-ACETYL-D-LEUCINE;N-ACETHY-D-LEUCINE;N-Acetyl-R-leucine
CBNumber:
CB3425987
Molecular Formula:
C8H15NO3
Molecular Weight:
173.21
MDL Number:
MFCD00066069
MOL File:
19764-30-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:19
Product description Number Pack Size Price
N-ACETYL-DL-LEUCINE AldrichCPR S451312 1 unit $197
N-Acetyl-D-leucine A0876 5g $432
N-ACETYL-DL-LEUCINE AldrichCPR S451312 50MG $172
N-Acetyl-D-leucine >99.0%(T) A0713 1g $72
N-acetyl-D-Leucine ≥95% 30489 50mg $44
More product size
Request For Quotation

N-Acetyl-D-leucine Properties

Melting point 176-177C
Boiling point 369.7±25.0 °C(Predicted)
Density 1.069±0.06 g/cm3(Predicted)
refractive index 23 ° (C=4, EtOH)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
pka 3.67±0.10(Predicted)
form Solid
color White to Off-White
InChI InChI=1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m1/s1
InChIKey WXNXCEHXYPACJF-SSDOTTSWSA-N
SMILES C(O)(=O)[C@@H](CC(C)C)NC(C)=O
CAS DataBase Reference 19764-30-8(CAS DataBase Reference)
FDA UNII 91WU82GA22
UNSPSC Code 12352209
NACRES NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H320-H335
Precautionary statements  P264-P270-P301+P312-P330
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  29241900
Storage Class 11 - Combustible Solids
NFPA 704
1
0 0

N-Acetyl-D-leucine price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S451312 N-ACETYL-DL-LEUCINE AldrichCPR 19764-30-8 1 unit $197 2026-03-19 Buy
Sigma-Aldrich A0876 N-Acetyl-D-leucine 19764-30-8 5g $432 2026-03-19 Buy
Sigma-Aldrich S451312 N-ACETYL-DL-LEUCINE AldrichCPR 19764-30-8 50MG $172 2023-06-20 Buy
TCI Chemical A0713 N-Acetyl-D-leucine >99.0%(T) 19764-30-8 1g $72 2026-03-19 Buy
Cayman Chemical 30489 N-acetyl-D-Leucine ≥95% 19764-30-8 50mg $44 2024-03-01 Buy
Product number Packaging Price Buy
S451312 1 unit $197 Buy
A0876 5g $432 Buy
S451312 50MG $172 Buy
A0713 1g $72 Buy
30489 50mg $44 Buy

N-Acetyl-D-leucine Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

N-Acetyl-D-leucine may be used with other D-aminoacylated amino acids as a substrate for the identification, differentiation and characterization of D-aminoacylase(s)/amidohydrolase(s).

Definition

ChEBI: N-acetyl-D-leucine is the N-acetyl derivative of D-leucine. It is a N-acetyl-D-amino acid and a D-leucine derivative. It is a conjugate acid of a N-acetyl-D-leucinate. It is an enantiomer of a N-acetyl-L-leucine.

Biological Activity

N-Acetyl-D-leucine is a substrate for D-aminoacylase from Alcaligenes xylosoxydans subsp. xylosoxydans A-6. N-Acetyl-D-leucine is used to help differentiate members of the amidohydrolase enzyme superfamily. It is a preferred substrate of Gox1177 from Gluconobacter oxidans.

Synthesis

D-2-Amino-4-methylpentanoic acid

328-38-1

Acetic anhydride

108-24-7

N-Acetyl-D-leucine

19764-30-8

Procedure: the preparation of compound 10 (N-acetyl-D-leucine) was carried out by an improved prior art method (see Am. Chem. Soc., 1951, 73, 3359-3360) as follows: In a 22-liter four-neck flask equipped with a thermocouple controller, an overhead mechanical stirrer, and two 2.0-liter dosing funnels. Deionized water (2.45 L) and D-leucine (99% e.e., 917.0 g, 7.0 mol) were added to the flask and stirring was initiated. Acetic anhydride (99%, 2142.0 g, 21.0 mol) and 20% aqueous NaOH solution (2.45 L, 49.0 mol) were added simultaneously and slowly dropwise over a period of 3 to 4 h. The temperature of the reaction was maintained between 5 and 15°C. The reaction temperature was controlled by adjusting the titration rate of the basic solution and acetic anhydride as well as wet ice cooling. The pH of the reaction mixture was maintained in the slightly basic range (pH 8-9) during the reaction using pH test paper every 10-15 min. The reaction process was monitored by HPLC and LC-MS. After completion of addition, stirring of the reaction mixture was continued for 1 h. Subsequently, acidification was carried out by slow addition of 37% HCl solution (4.76 L, 49.0 mol) over a period of 30 min. After acidification, a white solid precipitated and the slurry was stirred at 5°C to 15°C for 2 hours. The solid product was separated by filtration, washed with deionized water (2.0 L x 7), dried by air suction for 3 h, and finally dried in a vacuum oven at 60°C for 16 h (until the weight of the solid no longer decreased). Finally 1083 g (89% yield) of N-acetyl-D-leucine (compound 10) was obtained as a white powdery solid with high optical purity (>97% e.e.). The structure of the product was confirmed by 1H-NMR and LC-MS analyses and it could be used in subsequent steps without further purification.

in vivo

N-Acetyl-R-leucine (24 mg per rat; i.v.; once a day) has no significant effect on the compensation of nystagmus and postural imbalance scores in rats[4].

References

[1] Patent: WO2006/93719, 2006, A1. Location in patent: Page/Page column 34; 35
[2] Organic Process Research and Development, 2005, vol. 9, # 5, p. 640 - 645

N-Acetyl-D-leucine Preparation Products And Raw materials

Raw materials

D-Leucine, N-acetyl-, monopotassium salt (9CI) D-2-Amino-4-methylpentanoic acid D-Leucine, N-acetyl-, monosodium salt (9CI) Acetic anhydride Sodium hydroxide
Hydrochloric acid

1of2

Preparation Products

N-Acetyl-D-leucine Suppliers

Global( 371)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Sichuan HongRi Pharma-Tech Co.,Ltd 		+8618382028708 ni@enlaibio.com China 1098 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13815 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21592 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29821 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
Sichuan Jiaying Lai Technology Co.,LTD 		18716376478 ycling@enlaibio.com CHINA 302 58
Supplier Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd.
58
Sichuan HongRi Pharma-Tech Co.,Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Accela ChemBio Inc. 		58
Xiamen AmoyChem Co., Ltd 		58
Shandong chuangyingchemical Co., Ltd. 		58
Sichuan Jiaying Lai Technology Co.,LTD 		58

View Lastest Price from N-Acetyl-D-leucine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Acetyl-D-leucine pictures 2026-04-24 N-Acetyl-D-leucine
19764-30-8
 US $0.00 / KG 1KG 98.0% 50kg/month WUHAN FORTUNA CHEMICAL CO., LTD
AC-D-Leu-OH pictures 2026-04-24 AC-D-Leu-OH
19764-30-8
 US $0.00-0.00 / kg 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
AC-D-Leu-OH pictures 2020-01-06 AC-D-Leu-OH
19764-30-8
 US $1.00 / g 1g 98% 100KG Sichuan Jiaying Lai Technology Co.,LTD
  • AC-D-Leu-OH pictures
  • AC-D-Leu-OH
    19764-30-8
  • US $0.00-0.00 / kg
  • 98%
  • Sichuan HongRi Pharma-Tech Co.,Ltd
  • AC-D-Leu-OH pictures
  • AC-D-Leu-OH
    19764-30-8
  • US $1.00 / g
  • 98%
  • Sichuan Jiaying Lai Technology Co.,LTD

N-Acetyl-D-leucine Spectrum

N-Acetyl-D-leucine(19764-30-8)MSN-Acetyl-D-leucine(19764-30-8)IR1N-Acetyl-D-leucine(19764-30-8)IR2

19764-30-8(N-Acetyl-D-leucine)Related Search:

N-CARBOBENZOXY-DL-LEUCINE Acetyl coenzyme A sodium salt Acetyl chloride L-tert-Leucine Leucine aminopeptidase，porcine kidney
TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT GLYCYL-D-LEUCINE 21R-Argatroban Argatroban ACETYL-DL-LEUCINE,N-ALPHA-ACETYL-DL-LEUCINE,N-ACETYL-DL-LEUCINE,ACETYL-DL-LEUCINE, N-
H-TYR-D-ALA-GLY-PHE-D-LEU-OH (R)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline N-acetyl-L-leucine N-Acetyl-L-leucine N-(3-Indolylacetyl)-L-leucine, Indole-3-acetyl-L-leucine, 99%,INDOLE-3-ACETYL-L-LEUCINE 4-Methylvaleric acid
DL-Leucine H-LEU-D-LEU-OH GLY-GLY-D-LEU

1of4

2-Acetylamino-4-methylvaleric acid N-Acetyl-2-isobutylglycine D-2-Acetylamino-4-methylvaleric acid 2,N-Acetyl-D-leucine (R)-2-acetaMido-4-Methylpentanoic acid D-Leucine, N-acetyl- N-Ac-D-Leu-OH (R)-Ac-2-amino-4-methylpentanoic acid Acetyl-D-leucine≥ 98.5% (HPLC) AC-D-LEUCINE AC-D-LEU-OH ACETYL-D-LEUCINE N-ALPHA-ACETYL-D-LEUCINE N-ACETYL-D-LEUCINE n-acetyl-d-leucinesigmagr N-Acetyle-D-Leucine Ace-D-Leu-OH N-ACETYL-L-LEUCINE:AC-D-LEU-OH 2-(Acetylamino)-4-methylpentanoic acid N-ACETHY-D-LEUCINE N-Ac-D-Leucine N-Acetyl-R-leucine (2R)-2-acetamido-4-methylpentanoic acid N-Acetyl-D-leucine > (2R)-2-acetamido-4-methylpentanoicaci N-Acetyl-D-leucine USP/EP/BP CAS19764-30-8 N-Acetyl-D-leucine N-Acetyl-D-leucine,98 % N-Acetyl-D-leucine N-Acetyl-D-leucine 98%min 19764-30-8 16764-30-8 C8H15NO3 A - H Modified Amino Acids BioChemical Amino Acids and Peptides Biochemicals and Reagents Leucine [Leu, L] Ac-Amino Acids Amino Acids (N-Protected) Biochemistry N-Acetyl-Amino acid series A - H Amino ACIDS SERIES chiral Amino Acids amino acid Amino Acids Modified Amino Acids