ChemicalBook >> CAS DataBase List >>5-Bromo-2-fluorobenzonitrile
5-Bromo-2-fluorobenzonitrile
- CAS No.
- 179897-89-3
- Chemical Name:
- 5-Bromo-2-fluorobenzonitrile
- Synonyms
- 2-Fluoro-5-bromobenzonitrile;CAS:179897-89-3;Olapali impurity 6;Olapali impurity 17;2- fluorine-5-broMoxynil;5-BROMO-2-FLUOROBENZONITRILE;2-Flouro-5-bromobenzonitrile;2-Fliuoro-5-broMo Benzonitrile;Benzonitrile, 5-broMo-2-fluoro-;5-Bromo-2-fluorobenzonitrile98%
- CBNumber:
- CB3431412
- Molecular Formula:
- C7H3BrFN
- Molecular Weight:
- 200.01
- MDL Number:
- MFCD00143424
- MOL File:
- 179897-89-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 06:31:46
| Product description | Number | Pack Size | Price |
| 5-Bromo-2-fluorobenzonitrile 97% | 465259 | 5g | $28.5 |
| 5-Bromo-2-fluorobenzonitrile 97% | 465259 | 1g | $28.6 |
| 5-Bromo-2-fluorobenzonitrile >98.0%(GC) | B2425 | 5g | $38 |
| 5-Bromo-2-fluorobenzonitrile >98.0%(GC) | B2425 | 25g | $147 |
| 5-Bromo-2-fluorobenzonitrile, min. 98% min.98% | 09-0036 | 25g | $52 |
| More product size | |||
| Melting point | 76-81 °C |
|---|---|
| Boiling point | 220.4±20.0 °C(Predicted) |
| Density | 1.7286 (rough estimate) |
| refractive index | 1.5320 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| BRN | 7701063 |
| InChI | InChI=1S/C7H3BrFN/c8-6-1-2-7(9)5(3-6)4-10/h1-3H |
| InChIKey | GYCNHFWRPJXTSB-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC(Br)=CC=C1F |
| CAS DataBase Reference | 179897-89-3(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,T,Xi | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 36/37/39-26-22-36 | |||||||||
| RIDADR | 3439 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
5-Bromo-2-fluorobenzonitrile price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 465259 | 5-Bromo-2-fluorobenzonitrile 97% | 179897-89-3 | 5g | $28.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 465259 | 5-Bromo-2-fluorobenzonitrile 97% | 179897-89-3 | 1g | $28.6 | 2023-06-20 | Buy |
| TCI Chemical | B2425 | 5-Bromo-2-fluorobenzonitrile >98.0%(GC) | 179897-89-3 | 5g | $38 | 2026-04-30 | Buy |
| TCI Chemical | B2425 | 5-Bromo-2-fluorobenzonitrile >98.0%(GC) | 179897-89-3 | 25g | $147 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0036 | 5-Bromo-2-fluorobenzonitrile, min. 98% min.98% | 179897-89-3 | 25g | $52 | 2026-04-30 | Buy |
5-Bromo-2-fluorobenzonitrile Chemical Properties,Uses,Production
Chemical Properties
white to off-white powder or crystals
Uses
5-Bromo-2-fluorobenzonitrile may be used for the preparation of the following compounds:
- (E)-5-(2-cyclopropylvinyl)-2-fluorobenzonitrile and methyl-3-amino-5-bromobenzo[b]thiophene-2-carboxylate
- (S)-[2-[5-(3-cyano-4-fluoro-phenyl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethyl]-carbamic acid tert-butyl ester
- 4-fluoro-3-cyano-3′-tributyltinbenzhydrol
- 4-fluoro-3-cyano-3′-iodobenzhydrol
Synthesis
5-Bromo-2-fluorobenzonitrile is the key intermediate of the synthetic antigout drug Febuxostat. The synthesis method comprises the following steps: reacting o-fluorobenzoyl chloride with ammonia water to obtain o-fluorobenzamide; then generating o-fluorobenzonitrile under the action of a dehydration reagent; and finally, in 75-90% sulfuric acid, brominating with dibromohydantoin to obtain 5-bromo-2-fluorobenzonitrile. The synthesis method is simple and easy to implement, mild in conditions, low in production cost, and causes no wastewater discharge.
5-Bromo-2-fluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
3-Cyano-4-fluorobenzeneboronic acid
4-BROMO-2-HYDROXYBENZONITRILE
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
2-(tetrahydro-2H-pyran-4-yloxy)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
2-FLUORO-5-METHOXYBENZONITRILE
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Global( 390)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lianhe Aigen Pharmatech Co.,Ltd. | +86-18918657159; +undefined+undefined18918657159 | sales@lianhe-aigen.com | China | 300 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 923 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
View Lastest Price from 5-Bromo-2-fluorobenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-27 | 5-Bromo-2-fluorobenzonitrile
179897-89-3
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2025-06-20 | 5-Bromo-2-fluorobenzonitrile
179897-89-3
|
$1.00-10.00 | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2025-04-04 | 5-Bromo-2-fluorobenzonitrile
179897-89-3
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 5-Bromo-2-fluorobenzonitrile
179897-89-3
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 5-Bromo-2-fluorobenzonitrile
179897-89-3
- $1.00-10.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- 5-Bromo-2-fluorobenzonitrile
179897-89-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
179897-89-3(5-Bromo-2-fluorobenzonitrile)Related Search:
1of4
Benzonitrile, 5-broMo-2-fluoro-
2- fluorine-5-broMoxynil
2-Fliuoro-5-broMo Benzonitrile
5-Bromo-2-fluorobenzonitrile,97%
5-BROMO-2-FLUOROBENZONITRILE
2-Fluoro-5-bromobenzonitrile
5-Bromo-2-fluorobenzonitrile 98%
5-Bromo-2-fluorobenzonitrile98%
5-Bromo-2-fluorobenzonitrile >
5-Bromo-2-fluorobenzonitrile (Olaparib Impurity)
Olapali impurity 17
2-Flouro-5-bromobenzonitrile
Olapali impurity 6
CAS:179897-89-3
179897-89-3
Cyanides/Nitriles
Organic Building Blocks
Nitrogen Compounds
ARYL HALIDE
Building Blocks
C6 to C7
cyanide| alkyl bromide| alkyl Fluorine
Fluorine series
Febuxostat
Aromatic Nitriles
Nitrile
Miscellaneous
Bromine Compounds
Fluorine Compounds
Nitriles
C6 to C7
Cyanides/Nitriles
Nitrogen Compounds
Fluorobenzene
