3-BROMO-5-CHLOROTOLUENE
- CAS No.
- 329944-72-1
- Chemical Name:
- 3-BROMO-5-CHLOROTOLUENE
- Synonyms
- 3-bromo-5-chlorotlouene;3-BROMO-5-CHLOROTOLUENE;3-Bromo-5-chlorotoluene 98%;3-Chloro-5-methyl-bromobenzene;1-BROMO-3-CHLORO-5-METHYLBENZENE;Benzene,1-bromo-3-chloro-5-methyl-
- CBNumber:
- CB3442861
- Molecular Formula:
- C7H6BrCl
- Molecular Weight:
- 205.48
- MDL Number:
- MFCD08437596
- MOL File:
- 329944-72-1.mol
- MSDS File:
- SDS
| Melting point | 25℃ |
|---|---|
| Boiling point | 222.3±20.0℃ (760 Torr) |
| Density | 1.535±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | 101.5±11.9℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Ethyl Acetate |
| form | Solid |
| color | Pale Yellow |
| InChI | InChI=1S/C7H6BrCl/c1-5-2-6(8)4-7(9)3-5/h2-4H,1H3 |
| InChIKey | YRIKDGJWRMHTJP-UHFFFAOYSA-N |
| SMILES | C1(Br)=CC(C)=CC(Cl)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22 |
| Hazard Note | Irritant |
| HS Code | 2903998090 |
3-BROMO-5-CHLOROTOLUENE price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B682490 | 3-Bromo-5-chlorotoluene | 329944-72-1 | 10g | $130 | 2021-12-16 | Buy |
| TRC | B682490 | 3-Bromo-5-chlorotoluene | 329944-72-1 | 100g | $375 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB140165 | 1-Bromo-3-chloro-5-methylbenzene | 329944-72-1 | 100g | $462 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0021313 | 3-BROMO-5-CHLORO TOLUENE 95.00% | 329944-72-1 | 5G | $864.27 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 68224 | 3-Bromo-5-chlorotoluene | 329944-72-1 | 100g | $875 | 2021-12-16 | Buy |
3-BROMO-5-CHLOROTOLUENE Chemical Properties,Uses,Production
Uses
3-Bromo-5-chlorotoluene is a reagent used in the synthesis of novel benzophenones towards the discovery of potent, next generation HIV nonnucleoside reverse transcriptase inhibitors.
Synthesis
135340-78-2
329944-72-1
2-Bromo-6-chloro-4-methylaniline (30 mmol) was used as a starting material, which was dissolved in a mixed solution of acetic acid (60 mL), water (25 mL), and concentrated hydrochloric acid (7 mL), and the reaction system was subsequently cooled to 5 °C. A solution of sodium nitrite (48 mmol, 3.31 g) in water (12 mL) was added slowly and dropwise while keeping the temperature below 5 °C. After the dropwise addition, the reaction mixture was continued to be stirred at 5-10 °C for 2 hours. Subsequently, the reaction solution was poured into a 50% hypophosphite solution pre-cooled to 0 °C and stirred for 48 h at room temperature. Upon completion of the reaction, extraction was carried out with dichloromethane (3 x 120 mL). The organic phases were combined, washed with saturated saline (100 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. Finally, the residue was purified by fast column chromatography to obtain the target product 3-bromo-5-chlorotoluene.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 22, p. 5568 - 5572
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 12, p. 1866 - 1882
[3] Journal of Medicinal Chemistry, 2001, vol. 44, # 12, p. 1866 - 1882
3-BROMO-5-CHLOROTOLUENE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29733 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 12887 | 58 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 1382 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
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