K-252B
- CAS No.
- 99570-78-2
- Chemical Name:
- K-252B
- Synonyms
- K-252B;KT 5556;k-252b solution;K252B READY MADE;Antibiotic K 252b;K-252B, NOCARDIOPSIS SP;K-252B, NOCARDIOPSIS SPECIES;PROTEIN KINASE INHIBITOR K-252B;K252b Antibiotic K 252b KT 5556;(9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid
- CBNumber:
- CB3452783
- Molecular Formula:
- C26H19N3O5
- Molecular Weight:
- 453.45
- MDL Number:
- MFCD09878299
- MOL File:
- 99570-78-2.mol
- MSDS File:
- SDS
| Boiling point | 769.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.78±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 1 mg/ml). |
| form | ready-to-use solution |
| pka | 3.33±0.40(Predicted) |
| color | White or off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. |
| InChIKey | JCXYQIXTOQKHKB-VYNCDRPRNA-N |
| SMILES | N12C3=C(C4=C1C1=C(C5=C(N1[C@]1([H])O[C@@]2(C)[C@H](C(OO)=O)C1)C=CC=C5)C1C(=O)NCC=14)C=CC=C3 |&1:10,13,15,r| |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi |
|---|---|
| RIDADR | UN 1993 / PGIII |
| HS Code | 29349990 |
K-252B price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11339 | K252b ≥98% | 99570-78-2 | 500μg | $195 | 2024-03-01 | Buy |
| Cayman Chemical | 11339 | K252b ≥98% | 99570-78-2 | 1mg | $335 | 2024-03-01 | Buy |
| TRC | K000505 | K252b | 99570-78-2 | 2.5mg | $2180 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 65721 | K252b | 99570-78-2 | 2.5mg | $3200 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545968 | K252b >98% | 99570-78-2 | 1mg | $554.2 | 2021-12-16 | Buy |
K-252B Chemical Properties,Uses,Production
Description
K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C. However, as this compound does not freely pass through the cell membrane, it is used to inhibit extracellular kinases (ectokinases) of cells in culture. K252b inhibits receptor-
Chemical Properties
Yellow solid
Uses
K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. K252A exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. While K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).
Uses
K 252b, is an antibiotics, and a known protein tyrosine kinase inhibitor. It has been also shown to inhibit the trophic activity of brain-derived neurotrophic factor on dopaminergic (DAergic) neurons and nerve growth factor on basal forebrain cholinergic neurons.
References
[1] HIROSHI KASE. K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases[J]. Biochemical and biophysical research communications, 1987, 142 2: Pages 436-440. DOI:10.1016/0006-291x(87)90293-2
[2] KENICHI MAKINO. Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling.[J]. PLoS ONE, 2012: e41049. DOI:10.1371/journal.pone.0041049
K-252B Preparation Products And Raw materials
Raw materials
Preparation Products
K-252B Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32431 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 13675144456 | sean.lv@synzest.com | China | 11438 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 25003 | 65 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-846993838003-8003 18013301590 | njduly@126.com | China | 3157 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
