2-FLUORO-4-(TRIFLUOROMETHYL)CINNAMIC ACID
- CAS No.
- 262608-88-8
- Chemical Name:
- 2-FLUORO-4-(TRIFLUOROMETHYL)CINNAMIC ACID
- Synonyms
- RARECHEM AL BK 0319;2-FLUORO-4-(TRIFLUOROMETHYL)CINNAMIC ACID;3-(2-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid;3-[2-Fluoro-4-(trifluoromethyl)phenyl]-2-propenoic acid;(E)-3-2-Fluoro-4-(trifluoromethyl)phenylprop-2-enoic acid;2-Propenoic acid, 3-[2-fluoro-4-(trifluoromethyl)phenyl]-;(E)-3-[2-fluoro-4-(trifluoromethyl)phenyl]-2-propenoic acid;(2Z)-3-[2-fluoro-4-(trifluoromethyl)phenyl]prop-2-enoic acid
- CBNumber:
- CB3457490
- Molecular Formula:
- C10H6F4O2
- Molecular Weight:
- 234.15
- MDL Number:
- MFCD00236292
- MOL File:
- Mol file
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-(2-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid 95% | F53490 | 100mg | $11 |
| 3-(2-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid 95% | F53490 | 250mg | $17 |
| 3-(2-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid 95% | F53490 | 1g | $30 |
| 3-(2-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid 95% | F53490 | 5g | $120 |
| 2-Fluoro-4-(trifluoromethyl)cinnamic acid | 2921-3-49 | 5G | $132 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS03 |
|---|---|
| Signal word | Warning |
| Hazard statements | H272-H303 |
| Precautionary statements | P221-P270-P280-P301+P312-P370+P378r-P403-P501c |
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
| HS Code | 2916399090 |
2-FLUORO-4-(TRIFLUOROMETHYL)CINNAMIC ACID price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | F53490 | 3-(2-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid 95% | 262608-88-8 | 100mg | $11 | 2026-05-06 | Buy |
| Synthonix | F53490 | 3-(2-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid 95% | 262608-88-8 | 250mg | $17 | 2026-05-06 | Buy |
| Synthonix | F53490 | 3-(2-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid 95% | 262608-88-8 | 1g | $30 | 2026-05-06 | Buy |
| Synthonix | F53490 | 3-(2-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid 95% | 262608-88-8 | 5g | $120 | 2026-05-06 | Buy |
| SynQuest Laboratories | 2921-3-49 | 2-Fluoro-4-(trifluoromethyl)cinnamic acid | 262608-88-8 | 5G | $132 | 2021-12-16 | Buy |
2-FLUORO-4-(TRIFLUOROMETHYL)CINNAMIC ACID Chemical Properties,Uses,Production
Synthesis
141-82-2
89763-93-9
262608-88-8
Example 3: General procedure for the synthesis of 3-(2-fluoro-4-(trifluoromethyl)phenyl)acrylic acid from malonic acid and 2-fluoro-4-(trifluoromethyl)benzaldehyde. A mixture of 5.0 g (26.0 mmol) of 2-fluoro-4-(trifluoromethyl)benzaldehyde, 3.10 g (29.8 mmol) of malonic acid, 0.26 g (3.0 mmol) of piperidine, and 15 ml of pyridine was heated to reflux temperature until the release of carbon dioxide ceased (about 3 hours). After completion of the reaction, it was cooled to room temperature and the reaction mixture was poured into a mixture of 300 g of ice and 100 ml of 6N HCl. The precipitate was separated, washed twice sequentially with water and n-heptane and dried. 5.2 g (85% yield) of 3-(2-fluoro-4-(trifluoromethyl)phenyl)acrylic acid was obtained.1H-NMR (400MHz, D6-DMSO): δ= 6.73 (d, J = 16.1Hz, 1H, 2-H), 7.63 (d, 1H, 5'-H), 7.65 (d, J = 16.1Hz, 1H, 3-H), 7.76 (d , 1H, 3'-H), 8.07 (dd, 1H, 6'-H), 12.8 (br, 1H, COOH).
References
[1] Patent: US2005/38091, 2005, A1. Location in patent: Page column 6
[2] Patent: US2005/267179, 2005, A1. Location in patent: Page/Page column 15; 16
[3] Patent: WO2008/26149, 2008, A1. Location in patent: Page/Page column 22-23
2-FLUORO-4-(TRIFLUOROMETHYL)CINNAMIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-FLUORO-4-(TRIFLUOROMETHYL)CINNAMIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11598 | 64 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35896 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18207 | 66 | |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Henan Alpha Chemical Co., Ltd. | 0371-55055611 18137792234 | 3957071458@qq.com | China | 9940 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85563444 18351873721 | purchase@synzest.com | China | 10434 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44896 | 58 |
