OTS186935
- CAS No.
- 2093400-18-9
- Chemical Name:
- OTS186935
- Synonyms
- OTS186935;OTS-186935;OTS 186935;4-Pyridinemethanamine, N-[(3S)-1-[2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]-3-pyrrolidinyl]-
- CBNumber:
- CB34668317
- Molecular Formula:
- C25H26ClN5O2
- Molecular Weight:
- 463.96
- MDL Number:
- MFCD32067936
- MOL File:
- 2093400-18-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
OTS186935 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | TID40018 | OTS186935 | 2093400-18-9 | 10mg | $768.5 | 2026-06-05 | Buy |
| Biosynth | TID40018 | OTS186935 | 2093400-18-9 | 25mg | $1441 | 2026-06-05 | Buy |
| Biosynth | TID40018 | OTS186935 | 2093400-18-9 | 50mg | $2005 | 2026-06-05 | Buy |
| ChemScene | CS-0082468 | OTS186935 99.69% | 2093400-18-9 | 5mg | $325 | 2026-06-04 | Buy |
| ChemScene | CS-0082468 | OTS186935 99.69% | 2093400-18-9 | 10mg | $542 | 2026-06-04 | Buy |
OTS186935 Chemical Properties, Uses, Production
Description
OTS186935 is a protein methyltransferase SUV39H2 inhibitor. OTS186935 shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. It regulates the production of γ-H2AX in cancer cells.
Uses
OTS186935 is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 regulates the production of γ-H2AX in cancer cells[1].
in vivo
OTS186935 (10 mg/kg or 25 mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models[1].
| Animal Model: | Female NOD.CB17-Prkdcscid/J mice (bearing MDA-MB-231 cells )[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intravenously; once daily for 14 days |
| Result: | Tumor growth inhibition of 42.6% on day 14. |
| Animal Model: | Female BALB/cAJcl-nu/nu mice (bearing A549 cells)[1] |
| Dosage: | 25 mg/kg |
| Administration: | Intravenously; once daily for 14 days |
| Result: | Yielded a tumor growth inhibition of 60.8% without significant body weight loss or toxicity. |
References
[1] Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831. DOI:10.18632/oncotarget.25806
OTS186935 Preparation Products And Raw materials
Raw materials
Preparation Products
OTS186935 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| DC Chemicals | 021-58447131 13564518121 | doncunbiosci@gmail.com | China | 618 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
View Latest Price from OTS186935 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-16 | OTS186935
2093400-18-9
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2026-07-15 | OTS186935
2093400-18-9
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-07-18 | OTS186935
2093400-18-9
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
