5-(Trifluoromethyl)-1H-1,2,3-triazole
- CAS No.
- 40964-54-3
- Chemical Name:
- 5-(Trifluoromethyl)-1H-1,2,3-triazole
- Synonyms
- 4-(trifluoromethyl)-1H-1,2,3-triazole;4-(trifluoromethyl)-2H-triazole;5-trifluoromethyl-1,2,3-triazole;5-(Trifluoromethyl)-1H-1,2,3-triazole;1H-1,2,3-Triazole, 4-(trifluoromethyl)-;1H-1,2,3-Triazole, 5-(trifluoromethyl)-
- CBNumber:
- CB34674428
- Molecular Formula:
- C3H2F3N3
- Molecular Weight:
- 137.06
- MDL Number:
- MFCD27920868
- MOL File:
- 40964-54-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
5-(Trifluoromethyl)-1H-1,2,3-triazole price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | QBA96454 | 4-(Trifluoromethyl)-1H-1,2,3-triazole | 40964-54-3 | 50mg | $592.5 | 2026-06-04 | Buy |
| Biosynth | QBA96454 | 4-(Trifluoromethyl)-1H-1,2,3-triazole | 40964-54-3 | 0.5g | $1840.8 | 2026-06-04 | Buy |
| Activate Scientific | AS187567 | 5-(Trifluoromethyl)-1H-1,2,3-triazole 95% | 40964-54-3 | 100mg | $306 | 2026-06-04 | Buy |
| Activate Scientific | AS187567 | 5-(Trifluoromethyl)-1H-1,2,3-triazole 95% | 40964-54-3 | 250mg | $587 | 2026-06-04 | Buy |
| Activate Scientific | AS187567 | 5-(Trifluoromethyl)-1H-1,2,3-triazole 95% | 40964-54-3 | 1g | $1393 | 2026-06-04 | Buy |
5-(Trifluoromethyl)-1H-1,2,3-triazole Chemical Properties, Uses, Production
Definition
5-(Trifluoromethyl)-1H-1,2,3-triazole is a fluorinated triazole derivative. Triazoles are an important class of organic compounds, playing an important role in modern medicinal chemistry. Compounds with 1,2,3- and 1,2,4-triazole moieties are known to possess fungicidal, antimicrobial, anticonvulsant, antidepressant, antibacterial, anti-inflammatory, analgesic and antitumor activities[1].
Synthesis
A mixture of 1H-1,2,3-Triazole-4-carboxylic Acid (39.0 g, 345 mmol), anhyd HF (50 mL) and SF4 (46.5 g, 430 mmol) in a 500-mL autoclave was heated at 120 °C (oil bath temperature) for 16 h. The reaction mixture was cooled to 0 °C and the autoclave was then opened. The residue was put on a Teflon plate; after the residual HF had been removed by heating at 30 °C for 1–2 h (CAUTION! This procedure must be carried out in a fume hood!), the product was dissolved in CH2Cl2 (300 mL) to remove all insoluble materials. The solution was evaporated under vacuum and the thus-formed tarry residue was purified by double sublimation (20 mmHg, ～80–90 °C) to give 5-(Trifluoromethyl)-1H-1,2,3-triazole (30.3 g, 221 mmol, 64%) as a white solid[1].
References
[1] Mykhailiuk P, et al. Novel Synthetic Approaches to (Trifluoromethyl)triazoles. Synthesis, 2010; 7: 1075-1077.
5-(Trifluoromethyl)-1H-1,2,3-triazole Preparation Products And Raw materials
Raw materials
Preparation Products
5-(Trifluoromethyl)-1H-1,2,3-triazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Nantong Zandery Biotechnology Co., Ltd. | 0513-87582998 13912206938 | xiaofeizhu@vip.163.com | China | 272 | 55 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Shanghai Gugang New Materials Technology Co. Ltd. | 021-51317962 | 296935822@qq.com | China | 995 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-58859352 17714375163 | qzhang@aikonchem.com | China | 15525 | 58 |
| Wuhan chuang he chemical co. LTD | 15907120073 | 1261789306@qq.com | China | 1358 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39796 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Shanghai Yanbang Pharmaceutical Technology Co., Ltd | 15618536883 | 1228181347@qq.com | China | 7948 | 58 |
| SHAANXI?DIDEU?MEDICHEM CO.LTD | 17691182729 17392216275 | 1073@dideu.com | China | 9993 | 58 |
