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IDRA 21

IDRA 21 structure

CAS No.: 22503-72-6

Chemical Name:: IDRA 21

Synonyms: AMPAKINE;DRA 21;IDRA 21;IDRA 21,98%;IDRA-21, 10 mM in DMSO;S-18986 IDRA-21 AMPAKINE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE;7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-...;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE

CBNumber:: CB3468324

Molecular Formula:: C8H9ClN2O2S

Molecular Weight:: 232.69

MDL Number:: MFCD00270874

MOL File:: 22503-72-6.mol

MSDS File:: SDS

Last updated:2025-05-12 11:56:49

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IDRA 21 Properties

Melting point	209 °C(Solv: acetic acid (64-19-7))
Boiling point	405.1±55.0 °C(Predicted)
Density	1.394±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
pka	9.78±0.40(Predicted)
form	Solid
color	Off-White to Pale Yellow
InChI	InChI=1S/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3
InChIKey	VZRNTCHTJRLTMU-UHFFFAOYSA-N
SMILES	S1(=O)(=O)C2=CC(Cl)=CC=C2NC(C)N1
FDA UNII	689UW7PT68
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
Safety Statements	24/25
WGK Germany	3

IDRA 21 price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	I5773	IDRA 21 ≥98%	22503-72-6	5mg	$210	2024-03-01	Buy
Tocris	1219	IDRA 21 ≥98%(HPLC)	22503-72-6	10	$183	2021-12-16	Buy
Tocris	1219	IDRA 21 ≥98%(HPLC)	22503-72-6	50	$770	2021-12-16	Buy
Usbiological	255490	IDRA 21	22503-72-6	10mg	$423	2021-12-16	Buy
TRC	I232500	IDRA 21	22503-72-6	250mg	$1540	2021-12-16	Buy

Product number	Packaging	Price	Buy
I5773	5mg	$210	Buy
1219	10	$183	Buy
1219	50	$770	Buy
255490	10mg	$423	Buy
I232500	250mg	$1540	Buy

IDRA 21 Chemical Properties,Uses,Production

Chemical Properties

white to off-white crystalline powder

Uses

IDRA-21 inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960).

Uses

IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.

Definition

ChEBI: 7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide is a benzothiadiazine.

Biological Activity

Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide ).

storage

Room temperature

IDRA 21 synthesis

Synthesis of IDRA 21 from Hydrochlorothiazide Related Compound (N'-(2-Acetyl-sulfamoyl-4-chloro-phenyl) Acetamide)

IDRA 21 Preparation Products And Raw materials

Raw materials

2-Amino-5-chlorobenzenesulfonamide Hydrochlorothiazide Related Compound (N'-(2-Acetyl-sulfamoyl-4-chloro-phenyl) Acetamide) Ethanol Acetaldehyde

Preparation Products

IDRA 21 Suppliers

Global( 160)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Langyou International Trading Co., Ltd	+86-18874586545 +86-18874586545	linda@xrdchem.cn	China	196	58
Wuhan Qiami Technology Co., Ltd	+8618062705058	qiamichem@163.com	China	140	58
Hubei KDG Web Science&Technology Co., Ltd	18672314556 +8618672314556	sales@kdg-tech.com	China	933	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3883	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12788	58
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	lisa@kingfinertech.com	China	3005	58
Wuhan Haorong Biotechnology Co.,ltd	+86-18565342920; +8618565342920	sales@chembj.net	China	307	58
Hubei Chuyan Biopharmaceutical Co., Ltd	+1-027-87896938 +15172028168	chuyan@chuyan.co	China	24	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+86-17396673057	linda@tnjone.com	China	1143	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883 +86-16264648883	niki@zlchemi.com	China	7245	58

Supplier	Advantage
Hubei Langyou International Trading Co., Ltd	58
Wuhan Qiami Technology Co., Ltd	58
Hubei KDG Web Science&Technology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hebei Kingfiner Technology Development Co.Ltd	58
Wuhan Haorong Biotechnology Co.,ltd	58
Hubei Chuyan Biopharmaceutical Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58

View Lastest Price from IDRA 21 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-05-14	Idra-21 22503-72-6	US $150.00 / kg	1kg	99%	500kg	Hebei Zhuanglai Chemical Trading Co Ltd
2025-05-12	IDRA 21 22503-72-6	US $0.00-0.00 / g	10g	99%	8888g	Xi an Biohorlden Industry Trade Co Ltd
2025-05-12	IDRA-21 22503-72-6	US $59.00-157.00 / mg		99.73%	10g	TargetMol Chemicals Inc.

Idra-21
22503-72-6
US $150.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co Ltd

IDRA 21
22503-72-6
US $0.00-0.00 / g
99%
Xi an Biohorlden Industry Trade Co Ltd

IDRA-21
22503-72-6
US $59.00-157.00 / mg
99.73%
TargetMol Chemicals Inc.

22503-72-6(IDRA 21)Related Search:

Methyltrichlorosilane Benzyl chloride Triphosgene IDRA 21 2-Amino-5-chlorobenzenesulfonamide

IDRA 21 IDRA 21,7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazineS,S-dioxide 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE IDRA 21,98% 7-chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide 2H-1,2,4-Benzothiadiazine,7-chloro-3,4-dihydro-3-Methyl-, 1,1-dioxide AMPAKINE 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-... IDRA 21 Benzothiadiazine,7-chloro- 3,4-dihydro-3-methyl-,1,1- dioxide S-18986 IDRA-21 AMPAKINE DRA 21 IDRA-21, 10 mM in DMSO 22503-72-6 Ligand-Gated Ion Channels Ion Channels Ionotropic Glutamate Receptor Modulators Cell Signaling and Neuroscience Cell Biology BioChemical API