BMS-262084
- CAS No.
- 253174-92-4
- Chemical Name:
- BMS-262084
- Synonyms
- BMS-262084;I0IR71971G;CHEMBL71037;UNII-I0IR71971G;(2S,3R)-1-[4-(tert-butylcarbamoyl)piperazine-1-carbonyl]-3-[3-(diaminomethylideneamino)propyl]-4-oxoazetidine-2-carboxylicacid;2-Azetidinecarboxylic acid, 3-[3-[(aminoiminomethyl)amino]propyl]-1-[[4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperazinyl]carbonyl]-4-oxo-, (2S,3R)-
- CBNumber:
- CB34694585
- Molecular Formula:
- C18H31N7O5
- Molecular Weight:
- 425.48
- MDL Number:
- MFCD34567230
- MOL File:
- 253174-92-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.46±0.1 g/cm3(Predicted) |
|---|---|
| form | Solid |
| pka | 2.96±0.40(Predicted) |
| color | White to off-white |
| FDA UNII | I0IR71971G |
BMS-262084 Chemical Properties,Uses,Production
Uses
BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC50 of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC50=5 nM). BMS-262084 exhibits antithrombotic effects[1][2].
in vivo
BMS-262084 (2-12 mg/kg + 2-12 mg/kg/h; i.v.) reduces carotid artery thrombus weight and improves both vessel patency and integrated flow in rats[1].
| Animal Model: | Male Sprague Dawley rats (310-390 g) were induced venous thrombosis by FeCl2[1] |
| Dosage: | 2 mg/kg + 2 mg/kg/h, 6 mg/kg + 6 mg/kg/h, 12 mg/kg + 12 mg/kg/h |
| Administration: | I.v. 10 min before FeCl2 application |
| Result: | Reduced carotid artery thrombus weight by 73% at the dose of 12 mg/kg + 12 mg/kg/h. Improved both vessel patency and integrated flow. |
References
[1] Schumacher WA, et, al. Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats. Eur J Pharmacol. 2007 Sep 10;570(1-3):167-74. DOI:10.1016/j.ejphar.2007.05.043
[2] Qian X, et, al. A stereoselective synthesis of BMS-262084, an azetidinone-based tryptase inhibitor. J Org Chem. 2002 May 31;67(11):3595-600. DOI:10.1021/jo010757o
BMS-262084 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS-262084 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Langyou International Trading Co., Ltd | +86-12345678900 +86-18874586545 | linda@xrdchem.cn | China | 196 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Hebei Ningnan Trade Co. LTD | +86-18034019111 | admin@hbningnan.com | China | 255 | 58 |
| Hebei Shengyuan Jinlong Import and Export Co. LTD | +8617367750398 | info@hebeisyjl.com | China | 1838 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19957 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
View Lastest Price from BMS-262084 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | BMS-262084
253174-92-4
|
US $2780.00-3700.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2022-10-15 | BMS-262084
253174-92-4
|
US $10.00-200.00 / G | 100G | 99.99% | 20MT | Hebei Ningnan Trade Co. LTD | |
 |
2021-07-02 | BMS-262084
253174-92-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- BMS-262084
253174-92-4
- US $2780.00-3700.00 / mg
- TargetMol Chemicals Inc.
-
- BMS-262084
253174-92-4
- US $10.00-200.00 / G
- 99.99%
- Hebei Ningnan Trade Co. LTD
-
- BMS-262084
253174-92-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
