4-Bromo-2,6-dimethylphenol
- CAS No.
- 2374-05-2
- Chemical Name:
- 4-Bromo-2,6-dimethylphenol
- Synonyms
- AKOS BBB/373;4-bromo-6-xylenol;4-BROMO-2,6-XYLENOL;BROMO(4-)2,6-XYLENOL;2,6-Xylenol, 4-bromo-;4-Bromo-2,6-xylenol 97%;4-BROMO-2,6-DIMETHYLPHENOL;2,6-Dimethyl-4-bromophenol;Phenol, 4-bromo-2,6-dimethyl-;4-Bromo-2,6-dimethylphenol 99%
- CBNumber:
- CB3471641
- Molecular Formula:
- C8H9BrO
- Molecular Weight:
- 201.06
- MDL Number:
- MFCD00002314
- MOL File:
- 2374-05-2.mol
- MSDS File:
- SDS
| Melting point | 74-78 °C (lit.) |
|---|---|
| Boiling point | 195.33°C (rough estimate) |
| Density | 1.3646 (rough estimate) |
| refractive index | 1.5650 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | 10.10±0.23(Predicted) |
| color | White to Light yellow to Light orange |
| Water Solubility | Slightly soluble in water. |
| BRN | 1862399 |
| InChI | InChI=1S/C8H9BrO/c1-5-3-7(9)4-6(2)8(5)10/h3-4,10H,1-2H3 |
| InChIKey | ZLVFYUORUHNMBO-UHFFFAOYSA-N |
| SMILES | C1(O)=C(C)C=C(Br)C=C1C |
| CAS DataBase Reference | 2374-05-2(CAS DataBase Reference) |
| FDA UNII | PE2VSV8GBM |
| NIST Chemistry Reference | Phenol, 4-bromo-2,6-dimethyl-(2374-05-2) |
| EPA Substance Registry System | Phenol, 4-bromo-2,6-dimethyl- (2374-05-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ZE6780000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29081990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Bromo-2,6-dimethylphenol price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 196371 | 4-Bromo-2,6-xylenol 97% | 2374-05-2 | 100g | $100 | 2026-04-30 | Buy |
| TCI Chemical | B2060 | 4-Bromo-2,6-dimethylphenol >98.0%(GC) | 2374-05-2 | 25g | $175 | 2026-04-30 | Buy |
| TCI Chemical | B2060 | 4-Bromo-2,6-dimethylphenol >98.0%(GC) | 2374-05-2 | 250g | $1307 | 2026-04-30 | Buy |
| ChemScene | CS-0033720 | 4-Bromo-2,6-dimethylphenol ≥97% | 2374-05-2 | 25g | $25 | 2026-06-04 | Buy |
| ChemScene | CS-0033720 | 4-Bromo-2,6-dimethylphenol ≥97% | 2374-05-2 | 100g | $63 | 2026-06-04 | Buy |
4-Bromo-2,6-dimethylphenol Chemical Properties,Uses,Production
Chemical Properties
LIGHT PINK-BEIGE TO BROWN CRYSTALS OR POWDER
Uses
It is used as a preservatives for coatings, slurries and to control microbial fouling in paper mills , oil field and leather process and water treatment process against microbial attack.
Preparation
4-Bromo-2,6-dimethylphenol is prepared by bromination of 2,6-dimethylphenol in glacial acetic acid at 15 ℃ and used as a microbicide in disinfectants.
General Description
Iodine initiated polymerization of 4-bromo-2,6-xylenol in tetrahydrofuran solution has been investigated. 4-Bromo-2,6-xylenol on bromination in chloroform or carbobn tetrachloride yields 3,4-dibromo-2,6-xylenol and 3,4,5-tribromo-2,6-xylenol.
Synthesis
576-26-1
2374-05-2
In a 10 mL two-neck flask equipped with a reflux condenser, 2,6-dimethylphenol (0.25 mmol) and tetrabutylammonium bromide (161.2 mg, 0.50 mmol) were added. The flask was evacuated and backfilled three times with argon. To the reaction mixture was added ultrapure water (0.5 mL), trifluoroacetic acid (57.5 μL, 0.75 mmol) and 30% hydrogen peroxide (77 μL, 0.75 mmol). The reaction mixture was stirred at 25 °C under argon protection. Upon completion of the reaction, the reaction was quenched with 1:1 saturated aqueous sodium thiosulfate and saturated aqueous sodium bicarbonate and extracted with ether. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. 1,3,5-Trimethoxybenzene or hexamethylbenzene was added as an internal standard and the NMR yield of the product was determined by 1H NMR analysis. The spectral data obtained for 4-bromo-2,6-dimethylphenol were consistent with those of commercially available standards.
Toxicity evaluation
LD50 (i.p., mouse) 650 mg/kg.
References
[1] Bulletin of the Chemical Society of Japan, 1989, vol. 62, # 10, p. 3373 - 3375
[2] Synthetic Communications, 2010, vol. 40, # 21, p. 3226 - 3232
[3] Organic Letters, 2006, vol. 8, # 19, p. 4291 - 4293
[4] Chinese Chemical Letters, 2012, vol. 23, # 4, p. 387 - 390
[5] Organic Letters, 2015, vol. 17, # 12, p. 2886 - 2889
4-Bromo-2,6-dimethylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yuzhou Enthalpy Carbon Pharmaceutical Technology Co. LTD | 19963477321; 19963477321 | 2041275825@qq.com | China | 1541 | 58 |
| Creasyn Finechem(Tianjin) Co., Ltd. | 022-83946278 13820372920 | sales@creasyn.com | China | 968 | 68 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Lastest Price from 4-Bromo-2,6-dimethylphenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-06 | 4-Bromo-2,6-dimethylphenol
2374-05-2
|
$1.00 | 1KG | 95-99% | 100kg/week | Career Henan Chemical Co |
-
- 4-Bromo-2,6-dimethylphenol
2374-05-2
- $1.00
- 95-99%
- Career Henan Chemical Co
