Citrullinated Hsp70 (human recombinant)
- CAS No.
- Chemical Name:
- Citrullinated Hsp70 (human recombinant)
- Synonyms
- Citrullinated Hsp70 (human recombinant)
- CBNumber:
- CB34814428
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Citrullinated Hsp70 (human recombinant) price More Price(1)
Citrullinated Hsp70 (human recombinant) Chemical Properties, Uses, Production
Description
Heat shock protein 70s (Hsp70s) are abundant and stress-inducible 70 kDa molecular chaperone proteins encoded by a highly conserved, multigene family. They are monomeric proteins that can be divided into two functional domains: an N-terminal ATPase domain and a substrate binding domain that contains a highly conserved EEVD motif at its C-terminus. Hsp70s are found in the cytosol, nuclei, endoplasmic reticulum, mitochondria, and chloroplasts of eukaryotes, as well as in bacteria. They function as molecular chaperones that assist in a wide range of cellular processes, including refolding of aggregated or misfolded proteins, co- and post-translational folding and assembly of nascent peptides, membrane translocation of secretory and organellar proteins, controlling activity of regulatory nuclear receptors, kinases and transcription factors, as well as cooperativity with the Hsp90 chaperone system in eukaryotes. The Hsp70 chaperone cycle is ATP-dependent and initiated by transient interaction of the Hsp70 substrate binding domain with hydrophobic regions within a peptide or protein. It consists of an alteration between the low-affinity ATP-bound state with fast rates of substrate exchange and the high-affinity ADP bound state with slow rates of substrate exchange. Hsp70s are subject to a variety of post-translational modifications and their expression is upregulated under conditions of cellular stress and in a variety of disease states. Specifically, Hsp70 is subject to citrullination by peptidyl arginine deiminases (PADs) and citrullinated Hsp70 peptides have been found in the synovial fluid of patients with rheumatoid arthritis.
References
[1] FEI WANG. Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF.[J]. Clinical Rheumatology, 2016, 35 9: 2185-2194. DOI: 10.1007/s10067-016-3247-4
Citrullinated Hsp70 (human recombinant) Preparation Products And Raw materials
Raw materials
Preparation Products
Citrullinated Hsp70 (human recombinant) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Supplier | Advantage |
|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
