GB 1107)
- CAS No.
- 1978336-61-6
- Chemical Name:
- GB 1107)
- Synonyms
- GB 1107);GB1107 (GB-1107;GB1107, 10 mM in DMSO;α-D-Galactopyranoside, 3,4-dichlorophenyl 3-deoxy-1-thio-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-;(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(3,4,5-trifluorophenyl)triazol-1-yl]oxane-3,5-diol
- CBNumber:
- CB34844795
- Molecular Formula:
- C20H16Cl2F3N3O4S
- Molecular Weight:
- 522.32
- MDL Number:
- MFCD31813764
- MOL File:
- 1978336-61-6.mol
| Product description | Number | Pack Size | Price |
| GB1107 99.73% | CS-0084978 | 5mg | $157 |
| GB1107 99.73% | CS-0084978 | 10mg | $266 |
| GB1107 99.73% | CS-0084978 | 25mg | $564 |
| GB1107 99.73% | CS-0084978 | 50mg | $962 |
| GB1107 99.73% | CS-0084978 | 100mg | $1665 |
| Boiling point | 740.1±70.0 °C(Predicted) |
|---|---|
| Density | 1.73±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C,protect from light |
| solubility | DMSO:50.0(Max Conc. mg/mL);95.73(Max Conc. mM) |
| form | Solid |
| pka | 12.48±0.70(Predicted) |
| color | White to off-white |
| InChIKey | CSGJIUAIYDKFPC-XOZWYLPJNA-N |
| SMILES | O[C@H]1[C@H](O[C@H](CO)[C@H](O)[C@@H]1N1N=NC(C2C=C(F)C(F)=C(F)C=2)=C1)SC1C=CC(Cl)=C(Cl)C=1 |&1:1,2,4,7,9,r| |
GB 1107) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0084978 | GB1107 99.73% | 1978336-61-6 | 5mg | $157 | 2021-12-16 | Buy |
| ChemScene | CS-0084978 | GB1107 99.73% | 1978336-61-6 | 10mg | $266 | 2021-12-16 | Buy |
| ChemScene | CS-0084978 | GB1107 99.73% | 1978336-61-6 | 25mg | $564 | 2021-12-16 | Buy |
| ChemScene | CS-0084978 | GB1107 99.73% | 1978336-61-6 | 50mg | $962 | 2021-12-16 | Buy |
| ChemScene | CS-0084978 | GB1107 99.73% | 1978336-61-6 | 100mg | $1665 | 2021-12-16 | Buy |
GB 1107) Chemical Properties,Uses,Production
Description
GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade.
Uses
GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model[1].
in vivo
Oral administration of a novel small molecule galectin-3 inhibitor GB1107 reduced human and mouse lung adenocarcinoma growth and blocked metastasis in the syngeneic model. Treatment with GB1107 increased tumor M1 macrophage polarization and CD8+ T-cell infiltration. Moreover, GB1107 potentiated the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFNγ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules._x000D_ _x000D_ Reference: Cancer Res. 2019 Apr 1;79(7):1480-1492. https://pubmed.ncbi.nlm.nih.gov/30674531/
target
GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3.
IC 50
Galectin-3
References
[1] Vuong L, et al. An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. Cancer Res. 2019 Jan 23. pii: canres.2244.2018. DOI:10.1158/0008-5472.CAN-18-2244
GB 1107) Preparation Products And Raw materials
Raw materials
Preparation Products
GB 1107) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3210 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3506 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
