JNJ 4796)
- CAS No.
- 2241664-16-2
- Chemical Name:
- JNJ 4796)
- Synonyms
- JNJ 4796);JNJ4796 (JNJ-4796;Acetamide, N-[2-[2-[[4-[(R)-(2-methyl-2H-tetrazol-5-yl)phenylmethyl]-1-piperazinyl]carbonyl]-4-pyridinyl]-5-benzoxazolyl]-;(R)-N-(2-(2-(4-((2-methyl-2H-tetrazol-5-yl)(phenyl)methyl)piperazine-1-carbonyl)pyridin-4-yl)benzo[d]oxazol-5-yl)acetamide
- CBNumber:
- CB34844937
- Molecular Formula:
- C28H27N9O3
- Molecular Weight:
- 537.58
- MDL Number:
- MFCD32062806
- MOL File:
- 2241664-16-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
JNJ 4796) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | RPD66416 | JNJ 4796 | 2241664-16-2 | 1mg | $1038.4 | 2026-06-05 | Buy |
| Biosynth | RPD66416 | JNJ 4796 | 2241664-16-2 | 2mg | $1622.5 | 2026-06-05 | Buy |
| Biosynth | RPD66416 | JNJ 4796 | 2241664-16-2 | 5mg | $2596 | 2026-06-05 | Buy |
| Biosynth | RPD66416 | JNJ 4796 | 2241664-16-2 | 10mg | $4543 | 2026-06-05 | Buy |
| Biosynth | RPD66416 | JNJ 4796 | 2241664-16-2 | 25mg | $7139 | 2026-06-05 | Buy |
JNJ 4796) Chemical Properties, Uses, Production
Uses
JNJ4796 is an oral active fusion inhibitor of influenza virus, neutralizing influenza A group 1 viruses by inhibiting hemagglutinin (HA)-mediated fusion. JNJ4796 mimics the functionality of the broadly neutralizing antibodies (bnAbs)[1].
in vivo
Oral administration of JNJ4796 protects mice from lethal challenge of 25 times the median lethal dose (LD50) of H1N1 A/Puerto Rico/8/1934 virus. Doses of 50 and 10 mg/kg of JNJ4796 twice daily, initiated one day before challenge and continuing for 7 days, results in 100% survival at day 21 in comparison to the less potent compound JNJ8897 for which less than 50% survival is achieved[1].
Oral doses of JNJ4796 results in dose-dependent efficacy after a sublethal viral challenge (LD90), with twice daily administration of 15 and 5 mg/kg of JNJ4796 giving rise to 100% survival[1].
| Animal Model: | Female BALB/cAnNCrl mice intranasally infected with 2 × 25 μL of 25 × LD50 or 1 × LD90 of H1N1 A/Puerto Rico/8/34 dissolved in sterile phosphate buffered saline (D-PBS)[1] |
| Dosage: | 50 and 10 mg/kg. |
| Administration: | Oral twice daily for 7 days. |
| Result: | Resulted in 100% survival at day 21 in comparison to the less potent compound JNJ8897. |
References
[1] van Dongen MJP, et al. A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science. 2019 Mar 8;363(6431). DOI:10.1126/science.aar6221
JNJ 4796) Preparation Products And Raw materials
Raw materials
Preparation Products
JNJ 4796) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 15000803246 18149758185 | sales-cpd@caerulumpharma.com | China | 474 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
